Science 18 December 1992: Vol. 258. no. 5090, pp. 1955 - 1957 DOI: 10.1126/science.1470921

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Caenorhabditis elegans Genes Required for the Engulfment of Apoptotic Corpses Function in the Cytotoxic Cell Deaths Induced by Mutations in lin-24 and lin-33.

B. D. Galvin, S. Kim, and H. R. Horvitz (2008)
Genetics 179, 403-417
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Bcl-2-family proteins and hematologic malignancies: history and future prospects.

J. C. Reed (2008)
Blood 111, 3322-3330
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Pax2/5/8 proteins promote cell survival in C. elegans.

D. Park, H. Jia, V. Rajakumar, and H. M. Chamberlin (2006)
Development 133, 4193-4202
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Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1.

A. M. Jabbour, M. A. Puryer, J. Y. Yu, T. Lithgow, C. D. Riffkin, D. M. Ashley, D. L. Vaux, P. G. Ekert, and C. J. Hawkins (2006)
J. Cell Sci. 119, 2572-2582
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Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish.

D. M. Langenau, C. Jette, S. Berghmans, T. Palomero, J. P. Kanki, J. L. Kutok, and A. T. Look (2005)
Blood 105, 3278-3285
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Tomato Phospholipid Hydroperoxide Glutathione Peroxidase Inhibits Cell Death Induced by Bax and Oxidative Stresses in Yeast and Plants.

S. Chen, Z. Vaghchhipawala, W. Li, H. Asard, and M. B. Dickman (2004)
Plant Physiology 135, 1630-1641
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The Caenorhabditis elegans pvl-5 Gene Protects Hypodermal Cells From ced-3-Dependent, ced-4-Independent Cell Death.

P. Joshi and D. M. Eisenmann (2004)
Genetics 167, 673-685
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Ways of dying: multiple pathways to apoptosis.

J. M. Adams (2003)
Genes & Dev. 17, 2481-2495
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Inducible cAMP Early Repressor, an Endogenous Antagonist of cAMP Responsive Element-Binding Protein, Evokes Neuronal Apoptosis In Vitro.

J. Jaworski, B. Mioduszewska, A. Sanchez-Capelo, I. Figiel, A. Habas, A. Gozdz, T. Proszynski, M. Hetman, J. Mallet, and L. Kaczmarek (2003)
J. Neurosci. 23, 4519-4526
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The expanding role of mitochondria in apoptosis.

X. Wang (2001)
Genes & Dev. 15, 2922-2933
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Overexpression of Inducible Heat Shock Protein 70 in COS-1 Cells Fails to Protect From Cytotoxicity of Oxidized LDLs.

A. Pirillo, G. D. Norata, T. Zanelli, and A. L. Catapano (2001)
Arterioscler Thromb Vasc Biol 21, 348-354
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The midblastula transition in Xenopus embryos activates multiple pathways to prevent apoptosis in response to DNA damage.

C. V. Finkielstein, A. L. Lewellyn, and J. L. Maller (2001)
PNAS 98, 1006-1011
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Ovarian Toxicity of 4-Vinylcyclohexene Diepoxide: A Mechanistic Model.

P. B. Hoyer, P. J. Devine, Xiaoming Hu, K. E. Thompson, and I. G. Sipes (2001)
Toxicol Pathol 29, 91-99
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Presence of Fas-Fas Ligand System and Bcl-2 Gene Products in Cells and Fluids from Gonadotropin-Stimulated Human Ovaries1.

M. José de los Santos, D. J. Anderson, C. Racowsky, and J. A. Hill (2000)
Biol Reprod 63, 1811-1816
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Tissue-Specific Bcl-2 Protein Partners in Apoptosis: An Ovarian Paradigm.

S. Y. Hsu and A. J. W. Hsueh (2000)
Physiol Rev 80, 593-614
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Drosophila Apoptosis and Bcl-2 Genes: Outliers Fly in.

P. Chen and J. M. Abrams (2000)
J. Cell Biol. 148, 625-628
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Caspase-Dependent Cdk Activity Is a Requisite Effector of Apoptotic Death Events.

K. J. Harvey, D. Lukovic, and D. S. Ucker (2000)
J. Cell Biol. 148, 59-72
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Inhibition of Epidermal Growth Factor-induced Interleukin-1{beta}-converting Enzyme Expression Reduces Proliferation in the Pancreatic Carcinoma Cell Line AsPC-1.

S. Schlosser, F. Gansauge, T. Schnelldorfer, M. Ramadani, A. Schwarz, H.-G. Beger, and S. Gansauge (1999)
Cancer Res. 59, 4551-4554
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Life and Death in Otolaryngology: Mechanisms of Apoptosis and Its Role in the Pathology and Treatment of Disease.

S. P. Mostafapour, D. M. Hockenbery, and E. W Rubel (1999)
Arch Otolaryngol Head Neck Surg 125, 729-737
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Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway.

A. Gautreau, P. Poullet, D. Louvard, and M. Arpin (1999)
PNAS 96, 7300-7305
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Biochemical and Genetic Control of Apoptosis: Relevance to Normal Hematopoiesis and Hematological Malignancies.

R. G. Wickremasinghe and A. V. Hoffbrand (1999)
Blood 93, 3587-3600
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SAG, a Novel Zinc RING Finger Protein That Protects Cells from Apoptosis Induced by Redox Agents.

H. Duan, Y. Wang, M. Aviram, M. Swaroop, J. A. Loo, J. Bian, Y. Tian, T. Mueller, C. L. Bisgaier, and Y. Sun (1999)
Mol. Cell. Biol. 19, 3145-3155
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Apoptosis Induced by Drosophila Reaper and Grim in a Human System. ATTENUATION BY INHIBITOR OF APOPTOSIS PROTEINS (cIAPs).

J. V. McCarthy and V. M. Dixit (1998)
J. Biol. Chem. 273, 24009-24015
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The Bcl-2 Protein Family: Arbiters of Cell Survival.

J. M. Adams and S. Cory (1998)
Science 281, 1322-1326
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The Death Inhibitory Molecules CED-9 and CED-4L Use a Common Mechanism to Inhibit the CED-3 Death Protease.

D. Chaudhary, K. O'Rourke, A. M. Chinnaiyan, and V. M. Dixit (1998)
J. Biol. Chem. 273, 17708-17712
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Apoptosis : Basic Mechanisms and Implications for Cardiovascular Disease.

A. Haunstetter and S. Izumo (1998)
Circ. Res. 82, 1111-1129
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Proteases to die for.

V. Cryns and J. Yuan (1998)
Genes & Dev. 12, 1551-1570
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Commitment and Effector Phases of the Physiological Cell Death Pathway Elucidated with Respect to Bcl-2, Caspase, and Cyclin-Dependent Kinase Activities.

K. J. Harvey, J. F. Blomquist, and D. S. Ucker (1998)
Mol. Cell. Biol. 18, 2912-2922
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Bcl-2 Counters Apoptosis by Bax Heterodimerization-dependent and -independent Mechanisms in the T-cell Lineage.

E. G. St. Clair, S. J. Anderson, and Z. N. Oltvai (1997)
J. Biol. Chem. 272, 29347-29355
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Cancer Vaccines: The Molecular Basis for T Cell Killing of Tumor Cells.

J. E. Niederhuber (1997)
Oncologist 2, 280-283
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Interaction and Regulation of the Caenorhabditis elegans Death Protease CED-3 by CED-4 and CED-9.

D. Wu, H. D. Wallen, N. Inohara, and G. Nunez (1997)
J. Biol. Chem. 272, 21449-21454
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Activation of c-Jun N-terminal Kinase Antagonizes an Anti-apoptotic Action of Bcl-2.

J. Park, I. Kim, Y. J. Oh, K.-w. Lee, P.-L. Han, and E.-J. Choi (1997)
J. Biol. Chem. 272, 16725-16728
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Temporal Phases in Apoptosis Defined by the Actions of Src Homology 2 Domains, Ceramide, Bcl-2, Interleukin-1{beta} Converting Enzyme Family Proteases, and a Dense Membrane Fraction.

D. M. Farschon, C. Couture, T. Mustelin, and D. D. Newmeyer (1997)
J. Cell Biol. 137, 1117-1125
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DAD1, the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase.

D. J. Kelleher and R. Gilmore (1997)
PNAS 94, 4994-4999
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A Common Binding Site Mediates Heterodimerization and Homodimerization of Bcl-2 Family Members.

J.-L. Diaz, T. Oltersdorf, W. Horne, M. McConnell, G. Wilson, S. Weeks, T. Garcia, and L. C. Fritz (1997)
J. Biol. Chem. 272, 11350-11355
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Neuropathology of Degenerative Cell Death in Caenorhabditis elegans.

D. H. Hall, G. Gu, J. Garcia-Anoveros, L. Gong, M. Chalfie, and M. Driscoll (1997)
J. Neurosci. 17, 1033-1045
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Bax promotes neuronal cell death and is downregulated during the development of the nervous system.

K Vekrellis, M. McCarthy, A Watson, J Whitfield, L. Rubin, and J Ham (1997)
Development 124, 1239-1249
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Inhibition of interleukin 1beta -converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP.

C. J. Hawkins, A. G. Uren, G. Hacker, R. L. Medcalf, and D. L. Vaux (1996)
PNAS 93, 13786-13790
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Evidence for p53-Mediated Modulation of Neuronal Viability.

H. Xiang, D. W. Hochman, H. Saya, T. Fujiwara, P. A. Schwartzkroin, and R. S. Morrison (1996)
J. Neurosci. 16, 6753-6765
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Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities..

S Shaham and H R Horvitz (1996)
Genes & Dev. 10, 578-591
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Protease Activity of in Vitro Transcribed and Translated Caenorhabditis elegans Cell Death Gene (ced-3) Product.

M. Hugunin, L. J. Quintal, J. A. Mankovich, and T. Ghayur (1996)
J. Biol. Chem. 271, 3517-3522
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ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis.

H. Duan, A. M. Chinnaiyan, P. L. Hudson, J. P. Wing, W.-W. He, and V. M. Dixit (1996)
J. Biol. Chem. 271, 1621-1625
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Life and Death Decisions: ced-9 and Programmed Cell Death in Caenorhabditis elegans.

M. O. Hengartner (1995)
Science 270, 931
 |  Abstract »  |  PDF »

The head involution defective gene of Drosophila melanogaster functions in programmed cell death..

M E Grether, J M Abrams, J Agapite, K White, and H Steller (1995)
Genes & Dev. 9, 1694-1708
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Apoptosis as a Basic Mechanism in the Ovarian Cycle: Folicular Atresia and Luteal Regression.

A. Palumbo and J. Yeh (1995)
Reproductive Sciences 2, 565-573
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Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.

K Kuida, J. Lippke, G Ku, M. Harding, D. Livingston, M. Su, and R. Flavell (1995)
Science 267, 2000-2003
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Mechanisms and genes of cellular suicide.

H Steller (1995)
Science 267, 1445-1449
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Apoptosis in the pathogenesis and treatment of disease.

C. Thompson (1995)
Science 267, 1456-1462
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Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death..

L P Deiss, E Feinstein, H Berissi, O Cohen, and A Kimchi (1995)
Genes & Dev. 9, 15-30
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Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme..

S Kumar, M Kinoshita, M Noda, N G Copeland, and N A Jenkins (1994)
Genes & Dev. 8, 1613-1626
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Cell death genes: Drosophila enters the field.

M. Raff (1994)
Science 264, 668-669
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Differentiation-Dependent Expression of the BCL-2 Proto-Oncogene in the Human Trophoblast Lineage.

N. Sakuragi, H. Matsuo, G. Coukos, E. E. Furth, M. P. Bronner, C. M. VanArsdale, S. Krajewsky, J. C. Reed, and J. F. Strauss (1994)
Reproductive Sciences 1, 164-172
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Prevention of vertebrate neuronal death by the crmA gene.

V Gagliardini, P. Fernandez, R. Lee, H. Drexler, R. Rotello, M. Fishman, and J Yuan (1994)
Science 263, 826-828
 |  Abstract »  |  PDF »

Programmed cell death in Dictyostelium.

S Cornillon, C Foa, J Davoust, N Buonavista, J. Gross, and P Golstein (1994)
J. Cell Sci. 107, 2691-2704
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Enhanced Cell Survival and Tumorigenesis.

S. Cory, A. Strasser, T. Jacks, L.M. Corcoran, T. Metz, A.W. Harris, and J.M. Adams (1994)
Cold Spring Harb Symp Quant Biol 59, 365-375
 |  Abstract »  |  PDF »

The Genetics of Programmed Cell Death in the Nematode Caenorhabditis elegans.

H.R. Horvitz, S. Shaham, and M.O. Hengartner (1994)
Cold Spring Harb Symp Quant Biol 59, 377-385
 |  Abstract »  |  PDF »

The irregular chiasm C-roughest locus of Drosophila, which affects axonal projections and programmed cell death, encodes a novel immunoglobulin-like protein..

R G Ramos, G L Igloi, B Lichte, U Baumann, D Maier, T Schneider, J H Brandstatter, A Frohlich, and K F Fischbach (1993)
Genes & Dev. 7, 2533-2547
 |  Abstract »  |  PDF »

The Relationship Between [Ca2+]i and Cell Death Using an In Vivo Model: A Study Using the ced-1 Mutant Strain of C. elegans.

P. T. Jain, S. H. Chang, P. P. Gutry, I. K. Berezesky, and B. F. Trump (1993)
Toxicol Pathol 21, 572-583
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Programmed cell death and the control of cell survival: lessons from the nervous system.

M. Raff, B. Barres, J. Burne, H. Coles, Y Ishizaki, and M. Jacobson (1993)
Science 262, 695-700
 |  Abstract »  |  PDF »

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice.

K Nakayama, K Nakayama, I Negishi, K Kuida, Y Shinkai, M. Louie, L. Fields, P. Lucas, V Stewart, F. Alt, et al. (1993)
Science 261, 1584-1588
 |  Abstract »  |  PDF »

Genetic models for studying cancer susceptibility.

S. Friend (1993)
Science 259, 774-775
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Disruption of the CED-9{middle dot}CED-4 Complex by EGL-1 Is a Critical Step for Programmed Cell Death in Caenorhabditis elegans.

L. del Peso, V. M. Gonzalez, N. Inohara, R. E. Ellis, and G. Nunez (2000)
J. Biol. Chem. 275, 27205-27211
 |  Abstract »  |  Full Text »  |  PDF »

Abrogation of disease development in plants expressing animal antiapoptotic genes.

M. B. Dickman, Y. K. Park, T. Oltersdorf, W. Li, T. Clemente, and R. French (2001)
PNAS 98, 6957-6962
 |  Abstract »  |  Full Text »  |  PDF »

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