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Science 11 December 1992:
Vol. 258. no. 5089, pp. 1804 - 1808
DOI: 10.1126/science.1465618
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Articles

Science, Vol 258, Issue 5089, 1804-1808
Copyright © 1992 by American Association for the Advancement of Science

articles

Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice

Corboy JR, JM Buzy, MC Zink, and JE Clements

Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Infection with the human immunodeficiency virus (HIV) is frequently accompanied by the AIDS (acquired immunodeficiency syndrome) dementia complex. The role of specific HIV genetic elements in the pathogenesis of central nervous system (CNS) disease is not clear. Transgenic mice were constructed that contained the long terminal repeats (LTRs) of two CNS-derived strains and a T cell tropic strain of HIV-1. Only mice generated with CNS-derived LTRs directed expression in the CNS, particularly in neurons. Thus, some strains of HIV-1 have a selective advantage for gene expression in the brain, and neurons can supply the cellular factors necessary for their transcription.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Constitutive Nuclear Factor-kappa B Activity Is Required for Central Neuron Survival.
A. L. Bhakar, L.-L. Tannis, C. Zeindler, M. P. Russo, C. Jobin, D. S. Park, S. MacPherson, and P. A. Barker (2002)
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The long terminal repeat is a determinant of cell tropism of maedi-visna virus.
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Development of a Self-Inactivating Lentivirus Vector.
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COUP-TF and Sp1 Interact and Cooperate in the Transcriptional Activation of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat in Human Microglial Cells.
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Activation of the HIV-1 Long Terminal Repeat by Nerve Growth Factor.
J. A. Recio and A. Aranda (1997)
J. Biol. Chem. 272, 26807-26810
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Chicken Ovalbumin Upstream Promoter Transcription Factor, a Transcriptional Activator of HIV-1 Gene Expression in Human Brain Cells.
B. E. Sawaya, O. Rohr, D. Aunis, and E. Schaeffer (1996)
J. Biol. Chem. 271, 23572-23576
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Regulation of Human Immunodeficiency Virus Type 1Gene Transcription by Nuclear Receptors in Human Brain Cells.
B. E. Sawaya, O. Rohr, D. Aunis, and E. Schaeffer (1996)
J. Biol. Chem. 271, 22895-22900
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Science. ISSN 0036-8075 (print), 1095-9203 (online)