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Science 27 November 1992:
Vol. 258. no. 5087, pp. 1456 - 1462
DOI: 10.1126/science.1439838
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Articles

Science, Vol 258, Issue 5087, 1456-1462
Copyright © 1992 by American Association for the Advancement of Science

articles

Post-transcriptional regulation of early T cell development by T cell receptor signals

Y Takahama and A Singer

Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

During differentiation in the thymus, immature T cells progress through an ordered sequence of developmental stages that are best characterized by variable expression of the co-receptor molecules CD4 and CD8. Crosslinking of T cell receptor (TCR) molecules on precursor thymocytes was found to block their differentiation into CD4+CD8+ cells by eliminating messenger RNA's encoding two families of developmentally important molecules: the co-receptor molecules CD4 and CD8 and the recombination activating genes 1 and 2. TCR-induced post-transcriptional regulation in early thymocytes was specific for selective messenger RNA's, required protein synthesis, and was itself developmentally regulated. These data identify a post-transcriptional mechanism that is influenced by TCR signals and that regulates early thymocyte development.


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