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Science 20 November 1992:
Vol. 258. no. 5086, pp. 1369 - 1372
DOI: 10.1126/science.1455233
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Articles

Science, Vol 258, Issue 5086, 1369-1372
Copyright © 1992 by American Association for the Advancement of Science

articles

Encoding of a homolog of the IFN-gamma receptor by myxoma virus

C Upton, K Mossman, and G McFadden

Department of Biochemistry, University of Alberta, Edmonton, Canada.

Many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. The major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the M-T7 open reading frame. This protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (IFN-gamma). Furthermore, the myxoma M-T7 protein specifically binds rabbit IFN-gamma and inhibits the biological activity of extracellular IFN-gamma, one of the key regulatory cytokines in the host immune response against viral infections.


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