Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 November 1992:
Vol. 258. no. 5084, pp. 942 - 947
DOI: 10.1126/science.1439805
Prev | Table of Contents | Next

Articles

Science, Vol 258, Issue 5084, 942-947
Copyright © 1992 by American Association for the Advancement of Science

articles

The nuclear membrane

C Dingwall and R Laskey

Wellcome/CRC Institute, Cambridge, United Kingdom.

The nuclear membrane forms a major barrier within the cell, permitting levels of regulation not found in prokaryotes. The dynamics and diverse functions of the nuclear membrane and its associated structures are considered in this review. The role of the nuclear pore complex in selective transport across the nuclear membrane has been studied to a considerable degree; however, many crucial questions remain. Components of a signal transduction mechanism are associated with the nucleus, suggesting that nuclear functions may be influenced directly by this system. The involvement of the heat shock cognate protein Hsc70 in nuclear protein import is discussed, and a specific signal-presentation role for this protein is proposed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inositol Trisphosphate Receptor Ca2+ Release Channels.
J. K. Foskett, C. White, K.-H. Cheung, and D.-O. D. Mak (2007)
Physiol Rev 87, 593-658
   Abstract »    Full Text »    PDF »
Extracellular heat shock protein 70 has novel functional effects on sea urchin eggs and coelomocytes.
C. L. Browne, J. B. Swan, E. E. Rankin, H. Calvert, S. Griffiths, and M. Tytell (2007)
J. Exp. Biol. 210, 1275-1287
   Abstract »    Full Text »    PDF »
Rhinovirus 3C protease precursors 3CD and 3CD' localize to the nuclei of infected cells.
S. P. Amineva, A. G. Aminev, A. C. Palmenberg, and J. E. Gern (2004)
J. Gen. Virol. 85, 2969-2979
   Abstract »    Full Text »    PDF »
Identification of Novel Nuclear Export and Nuclear Localization-related Signals in Human Heat Shock Cognate Protein 70.
F. Tsukahara and Y. Maru (2004)
J. Biol. Chem. 279, 8867-8872
   Abstract »    Full Text »    PDF »
Identification of the nuclear localization signals within the Epstein-Barr virus EBNA-6 protein.
K. Krauer, M. Buck, J. Flanagan, D. Belzer, and T. Sculley (2004)
J. Gen. Virol. 85, 165-172
   Abstract »    Full Text »    PDF »
Mechanism of Specific Nuclear Transport of Adriamycin: The Mode of Nuclear Translocation of Adriamycin-Proteasome Complex.
K.-i. Kiyomiya, S. Matsuo, and M. Kurebe (2001)
Cancer Res. 61, 2467-2471
   Abstract »    Full Text »
The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases.
D. Davy, H. Campbell, S Fountain, D de Jong, and M. Crouch (2001)
J. Cell Sci. 114, 549-562
   Abstract »    PDF »
Electrical Dimension of the Nuclear Envelope.
M. Mazzanti, J. O. Bustamante, and H. Oberleithner (2001)
Physiol Rev 81, 1-19
   Abstract »    Full Text »    PDF »
Single-Channel Properties in Endoplasmic Reticulum Membrane of Recombinant Type 3 Inositol Trisphosphate Receptor.
D.-O. D. Mak, S. McBride, V. Raghuram, Y. Yue, S. K. Joseph, and J. K. Foskett (2000)
J. Gen. Physiol. 115, 241-256
   Abstract »    Full Text »    PDF »
Gating mechanism of the nuclear pore complex channel in isolated neonatal and adult mouse liver nuclei.
R. TONINI, F. GROHOVAZ, C. A. M. LAPORTA, and M. MAZZANTI (1999)
FASEB J 13, 1395-1403
   Abstract »    Full Text »
Structural Plasticity of the Cardiac Nuclear Pore Complex in Response to Regulators of Nuclear Import.
C. Perez-Terzic, A. M. Gacy, R. Bortolon, P. P. Dzeja, M. Puceat, M. Jaconi, F. G. Prendergast, and A. Terzic (1999)
Circ. Res. 84, 1292-1301
   Abstract »    Full Text »    PDF »
The Oncogenic Potential of the Pax3-FKHR Fusion Protein Requires the Pax3 Homeodomain Recognition Helix but Not the Pax3 Paired-Box DNA Binding Domain.
P. Y. P. Lam, J. E. Sublett, A. D. Hollenbach, and M. F. Roussel (1999)
Mol. Cell. Biol. 19, 594-601
   Abstract »    Full Text »    PDF »
Effects of divalent cations on single-channel conduction properties of Xenopus IP3 receptor.
D.-O. D. Mak and J. K. Foskett (1998)
Am J Physiol Cell Physiol 275, C179-C188
   Abstract »    Full Text »    PDF »
Single-Channel Kinetics, Inactivation, and Spatial Distribution of Inositol Trisphosphate (IP3) Receptors in Xenopus Oocyte Nucleus.
D.-O. D. Mak and J. K. Foskett (1997)
J. Gen. Physiol. 109, 571-587
   Abstract »    Full Text »    PDF »
Interphase Nuclei of Many Mammalian Cell Types Contain Deep, Dynamic, Tubular Membrane-bound Invaginations of the Nuclear Envelope.
M. Fricker, M. Hollinshead, N. White, and D. Vaux (1997)
J. Cell Biol. 136, 531-544
   Abstract »    Full Text »    PDF »
Distinct egg membrane vesicles differing in binding and fusion properties contribute to sea urchin male pronuclear envelopes formed in vitro.
P Collas and D Poccia (1996)
J. Cell Sci. 109, 1275-1283
   Abstract »    PDF »
Inositol 1,4,5-Trisphosphate Receptor Is Located to the Inner Nuclear Membrane Vindicating Regulation of Nuclear Calcium Signaling by Inositol 1,4,5-Trisphosphate.
J.-P. Humbert, N. Matter, J.-C. Artault, P. Köppler, and A. N. Malviya (1996)
J. Biol. Chem. 271, 478-485
   Abstract »    Full Text »    PDF »
The hydrothermal imprint on life: did heat-shock proteins, metalloproteins and photosynthesis begin around hydrothermal vents?.
E. G. Nisbet and C. M. R. Fowler (1996)
Geological Society, London, Special Publications 118, 239-251
   Abstract »    PDF »
Diffusion Across the Nuclear Envelope Inhibited by Depletion of the Nuclear Ca2+ Store.
L. Stehno-Bittel, C. Perez-Terzic, and D. E. Clapham (1995)
Science 270, 1835-1838
   Abstract »    PDF »
The Nuclear Pore Complex Protein p62 Is One of Several Sialic Acid-containing Proteins of the Nuclear Envelope.
S. Emig, D. Schmalz, M. Shakibaei, and K. Buchner (1995)
J. Biol. Chem. 270, 13787-13793
   Abstract »    Full Text »    PDF »
Mutant ([IMAGE]F508) Cystic Fibrosis Transmembrane Conductance Regulator Cl[IMAGE] Channel Is Functional When Retained in Endoplasmic Reticulum of Mammalian Cells.
E. A. Pasyk and J. K. Foskett (1995)
J. Biol. Chem. 270, 12347-12350
   Abstract »    Full Text »    PDF »
The mechanism of nuclear transport of natural or artificial transport substrates in digitonin-permeabilized cells.
I Cserpan and A Udvardy (1995)
J. Cell Sci. 108, 1849-1861
   Abstract »    PDF »
Nucleo-cytoplasmic distribution of human hnRNP proteins: a search for the targeting domains in hnRNP A1.
F Weighardt, G Biamonti, and S Riva (1995)
J. Cell Sci. 108, 545-555
   Abstract »    PDF »
Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina in human cells.
P Hozak, A. Sasseville, Y Raymond, and P. Cook (1995)
J. Cell Sci. 108, 635-644
   Abstract »    PDF »
Germ cell-less encodes a cell type-specific nuclear pore-associated protein and functions early in the germ-cell specification pathway of Drosophila..
T A Jongens, L D Ackerman, J R Swedlow, L Y Jan, and Y N Jan (1994)
Genes & Dev. 8, 2123-2136
   Abstract »    PDF »
Redistribution of cytoplasmic components during germinal vesicle breakdown in starfish oocytes.
M. Terasaki (1994)
J. Cell Sci. 107, 1797-1805
   Abstract »    PDF »
The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm..
B E Meyer and M H Malim (1994)
Genes & Dev. 8, 1538-1547
   Abstract »    PDF »
Nuclear localization of vertebrate cyclin A correlates with its ability to form complexes with cdk catalytic subunits.
G Maridor, P Gallant, R Golsteyn, and E. Nigg (1993)
J. Cell Sci. 106, 535-544
   Abstract »    PDF »
Protein localization to the nucleolus: a search for targeting domains in nucleolin.
M. Schmidt-Zachmann and E. Nigg (1993)
J. Cell Sci. 105, 799-806
   Abstract »    PDF »
Signal transduction and nuclear targeting: regulation of transcription factor activity by subcellular localisation.
S. Whiteside and S Goodbourn (1993)
J. Cell Sci. 104, 949-955
   PDF »
Nuclear Import of Insulin-like Growth Factor-binding Protein-3 and -5 Is Mediated by the Importin beta Subunit.
L. J. Schedlich, S. L. Le Page, S. M. Firth, L. J. Briggs, D. A. Jans, and R. C. Baxter (2000)
J. Biol. Chem. 275, 23462-23470
   Abstract »    Full Text »    PDF »
Directed Inhibition of Nuclear Import in Cellular Hypertrophy.
C. Perez-Terzic, A. M. Gacy, R. Bortolon, P. P. Dzeja, M. Puceat, M. Jaconi, F. G. Prendergast, and A. Terzic (2001)
J. Biol. Chem. 276, 20566-20571
   Abstract »    Full Text »    PDF »
N-terminal Region, C-terminal Region, Nuclear Export Signal, and Deacetylation Activity of Histone Deacetylase-3 Are Essential for the Viability of the DT40 Chicken B Cell Line.
Y. Takami and T. Nakayama (2000)
J. Biol. Chem. 275, 16191-16201
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)