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Science 23 October 1992:
Vol. 258. no. 5082, pp. 597 - 603
DOI: 10.1126/science.1329206
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Articles

Science, Vol 258, Issue 5082, 597-603
Copyright © 1992 by American Association for the Advancement of Science

articles

Molecular diversity of glutamate receptors and implications for brain function

S Nakanishi

Institute for Immunology, Kyoto University Faculty of Medicine, Japan.

The glutamate receptors mediate excitatory neurotransmission in the brain and are important in memory acquisition, learning, and some neurodegenerative disorders. This receptor family is classified in three groups: the N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-kainate, and metabotropic receptors. Recent molecular studies have shown that many receptor subtypes exist in all three groups of the receptors and exhibit heterogeneity in function and expression patterns. This article reviews the molecular and functional diversity of the glutamate receptors and discusses their implications for integrative brain function.


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PNAS 99, 7119-7123
   Abstract »    Full Text »    PDF »
Ischemia and Ischemic Tolerance Induction Differentially Regulate Protein Expression of GluR1, GluR2, and AMPA Receptor Binding Protein in the Gerbil Hippocampus: GluR2 (GluR-B) Reduction Does Not Predict Neuronal Death.
C. Sommer and M. Kiessling (2002)
Stroke 33, 1093-1100
   Abstract »    Full Text »    PDF »
Tamalin, a PDZ Domain-Containing Protein, Links a Protein Complex Formation of Group 1 Metabotropic Glutamate Receptors and the Guanine Nucleotide Exchange Factor Cytohesins.
J. Kitano, K. Kimura, Y. Yamazaki, T. Soda, R. Shigemoto, Y. Nakajima, and S. Nakanishi (2002)
J. Neurosci. 22, 1280-1289
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The Disposition, Metabolism, and Pharmacokinetics of a Selective Metabotropic Glutamate Receptor Agonist in Rats and Dogs.
J. T. Johnson, E. L. Mattiuz, S. H. Chay, J. L. Herman, W. J. Wheeler, K. Kassahun, S. P. Swanson, and D. L. Phillips (2002)
Drug Metab. Dispos. 30, 27-33
   Abstract »    Full Text »    PDF »
Characterization of the Rat GRIK5 Kainate Receptor Subunit Gene Promoter and Its Intragenic Regions Involved in Neural Cell Specificity.
L.-J. Chew, X. Yuan, S. E. Scherer, L. Qie, F. Huang, W. P. Hayes, and V. Gallo (2001)
J. Biol. Chem. 276, 42162-42171
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Prenatal Exposure of Testosterone Prevents SDN-POA Neurons of Postnatal Male Rats From Apoptosis Through NMDA Receptor.
H.-K. Hsu, R.-C. Yang, H.-C. Shih, Y.-L. Hsieh, U-Y. Chen, and C. Hsu (2001)
J Neurophysiol 86, 2374-2380
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Identification of Essential Residues Involved in the Glutamate Binding Pocket of the Group II Metabotropic Glutamate Receptor.
P. Malherbe, F. Knoflach, C. Broger, S. Ohresser, C. Kratzeisen, G. Adam, H. Stadler, J. A. Kemp, and V. Mutel (2001)
Mol. Pharmacol. 60, 944-954
   Abstract »    Full Text »    PDF »
Unveiling the Functions of Presynaptic Metabotropic Glutamate Receptors in the Central Nervous System.
D. D. Schoepp (2001)
J. Pharmacol. Exp. Ther. 299, 12-20
   Abstract »    Full Text »    PDF »
The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia.
D. C. Goff and J. T. Coyle (2001)
Am J Psychiatry 158, 1367-1377
   Abstract »    Full Text »    PDF »
Synaptic Plasticity in the Lateral Amygdala: A Cellular Hypothesis of Fear Conditioning.
H. T. Blair, G. E. Schafe, E. P. Bauer, S. M. Rodrigues, and J. E. LeDoux (2001)
Learn. Mem. 8, 229-242
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Intra-Amygdala Blockade of the NR2B Subunit of the NMDA Receptor Disrupts the Acquisition But Not the Expression of Fear Conditioning.
S. M. Rodrigues, G. E. Schafe, and J. E. LeDoux (2001)
J. Neurosci. 21, 6889-6896
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Metabotropic Glutamate Receptors 1 and 5 Differentially Regulate CA1 Pyramidal Cell Function.
G. Mannaioni, M. J. Marino, O. Valenti, S. F. Traynelis, and P. J. Conn (2001)
J. Neurosci. 21, 5925-5934
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[3H]LY341495 Binding to Group II Metabotropic Glutamate Receptors in Rat Brain.
R. A. Wright, M. B. Arnold, W. J. Wheeler, P. L. Ornstein, and D. D. Schoepp (2001)
J. Pharmacol. Exp. Ther. 298, 453-460
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Qualitative Light and Electron Microscope Study of Glutamate Receptors in the Caudal Spinal Trigeminal Nucleus of the Rat.
F.R. Tang, J.F. Yeo, and S.K. Leong (2001)
Journal of Dental Research 80, 1736-1741
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Blockade of D1 Dopamine Receptors in the Ventral Tegmental Area Decreases Cocaine Reward: Possible Role for Dendritically Released Dopamine.
R. Ranaldi and R. A. Wise (2001)
J. Neurosci. 21, 5841-5846
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cAMP-Dependent Protein Kinase Mediates Activity-Regulated Synaptic Targeting of NMDA Receptors.
F. T. Crump, K. S. Dillman, and A. M. Craig (2001)
J. Neurosci. 21, 5079-5088
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Group II and III metabotropic glutamate receptors contribute to different aspects of visual response processing in the rat superior colliculus.
J. Cirone and T. E Salt (2001)
J. Physiol. 534, 169-178
   Abstract »    Full Text »    PDF »
Pharmacological Properties of the Potent Epileptogenic Amino Acid Dysiherbaine, a Novel Glutamate Receptor Agonist Isolated from the Marine Sponge Dysidea herbacea.
R. Sakai, G. T. Swanson, K. Shimamoto, T. Green, A. Contractor, A. Ghetti, Y. Tamura-Horikawa, C. Oiwa, and H. Kamiya (2001)
J. Pharmacol. Exp. Ther. 296, 650-658
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Correlative Association between N-Methyl-D-Aspartate Receptor-Mediated Expression of Period Genes in the Suprachiasmatic Nucleus and Phase Shifts in Behavior with Photic Entrainment of Clock in Hamsters.
T. Moriya, K. Horikawa, M. Akiyama, and S. Shibata (2001)
Mol. Pharmacol. 58, 1554-1562
   Abstract »    Full Text »


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