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Science 23 October 1992: Vol. 258. no. 5082, pp. 593 - 597 DOI: 10.1126/science.1411569
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Articles
Science, Vol 258, Issue 5082, 593-597
Copyright © 1992 by American Association for the Advancement of Science
Interleukin-6 and its receptor: a paradigm for cytokines
T Kishimoto,
S Akira,
and
T Taga
Department of Internal Medicine III, Osaka University Medical School, Japan.
Many cytokines and cytokine receptors involved in the regulation of hematopoiesis, immune responses, and inflammation have been identified and characterized at the molecular level. Several characteristic features of cytokines, such as pleiotropy and redundancy, are now more clearly understood on the basis of their molecular structures. Accumulating evidence has demonstrated an intimate link between cytokines and various diseases such as allergy, autoimmune diseases, and cancer. The pathogenesis of these diseases and therapies to treat them will be discussed based on insights derived from cytokine research.
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- Synergistic Activity of STAT3 and c-Jun at a Specific Array of DNA Elements in the alpha 2-Macroglobulin Promoter.
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- Vascular Endothelial Growth Factor Receptor-2 and Neuropilin-1 Form a Receptor Complex That Is Responsible for the Differential Signaling Potency of VEGF165 and VEGF121.
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