Science 25 September 1992: Vol. 257. no. 5078, pp. 1955 - 1957 DOI: 10.1126/science.1384126

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Articles

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents.

(2009)
Mol. Cancer Ther. 8, 2992-3000

A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells.

T. Yamada, R. R. Mehta, F. Lekmine, K. Christov, M. L. King, D. Majumdar, A. Shilkaitis, A. Green, L. Bratescu, C. W. Beattie, et al. (2009)
Mol. Cancer Ther. 8, 2947-2958
 |  Abstract »  |  Full Text »  |  PDF »

Fine Tuning the Cell Cycle: Activation of the Cdk1 Inhibitory Phosphorylation Pathway during Mitotic Exit.

T. A. Potapova, J. R. Daum, K. S. Byrd, and G. J. Gorbsky (2009)
Mol. Biol. Cell 20, 1737-1748
 |  Abstract »  |  Full Text »  |  PDF »

90-kDa Heat Shock Protein Inhibition Abrogates the Topoisomerase I Poison-Induced G2/M Checkpoint in p53-Null Tumor Cells by Depleting Chk1 and Wee1.

A. N. Tse, T. N. Sheikh, H. Alan, T.-C. Chou, and G. K. Schwartz (2009)
Mol. Pharmacol. 75, 124-133
 |  Abstract »  |  Full Text »  |  PDF »

Fertilization differently affects the levels of cyclin B1 and M-phase promoting factor activity in maturing and metaphase II mouse oocytes.

A. Ajduk, M. A Ciemerych, V. Nixon, K. Swann, and M. Maleszewski (2008)
Reproduction 136, 741-752
 |  Abstract »  |  Full Text »  |  PDF »

CDC25B Acts as a Potential Target of PRKACA in Fertilized Mouse Eggs.

C. Cui, H. Zhao, Z. Zhang, Z. Zong, C. Feng, Y. Zhang, X. Deng, X. Xu, and B. Yu (2008)
Biol Reprod 79, 991-998
 |  Abstract »  |  Full Text »  |  PDF »

Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit.

H. Nakajima, S. Yonemura, M. Murata, N. Nakamura, H. Piwnica-Worms, and E. Nishida (2008)
J. Cell Biol. 181, 89-103
 |  Abstract »  |  Full Text »  |  PDF »

The Oncogenic microRNA-27a Targets Genes That Regulate Specificity Protein Transcription Factors and the G2-M Checkpoint in MDA-MB-231 Breast Cancer Cells.

S. U. Mertens-Talcott, S. Chintharlapalli, X. Li, and S. Safe (2007)
Cancer Res. 67, 11001-11011
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of the Schizosaccharomyces pombe cut12.1 Cell-Cycle Defect by Mutations in cdc25 and Genes Involved in Transcriptional and Translational Control.

V. A. Tallada, A. J. Bridge, P. A. Emery, and I. M. Hagan (2007)
Genetics 176, 73-83
 |  Abstract »  |  Full Text »  |  PDF »

Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement.

T. M. Kiviharju-af Hallstrom, S. Jaamaa, M. Monkkonen, K. Peltonen, L. C. Andersson, R. H. Medema, D. M. Peehl, and M. Laiho (2007)
PNAS 104, 7211-7216
 |  Abstract »  |  Full Text »  |  PDF »

How Tyrosine 15 Phosphorylation Inhibits the Activity of Cyclin-dependent Kinase 2-Cyclin A.

J. P. I. Welburn, J. A. Tucker, T. Johnson, L. Lindert, M. Morgan, A. Willis, M. E. M. Noble, and J. A. Endicott (2007)
J. Biol. Chem. 282, 3173-3181
 |  Abstract »  |  Full Text »  |  PDF »

Absolute Quantification of Multisite Phosphorylation by Selective Reaction Monitoring Mass Spectrometry: Determination of Inhibitory Phosphorylation Status of Cyclin-Dependent Kinases.

V. Mayya, K. Rezual, L. Wu, M. B. Fong, and D. K. Han (2006)
Mol. Cell. Proteomics 5, 1146-1157
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of WASP by the Cdc42-associated Kinase ACK1: DUAL HYDROXYAMINO ACID SPECIFICITY IN A TYROSINE KINASE.

N. Yokoyama, J. Lougheed, and W. T. Miller (2005)
J. Biol. Chem. 280, 42219-42226
 |  Abstract »  |  Full Text »  |  PDF »

The Ste20-like Kinase SLK Is Required for Cell Cycle Progression through G2.

P. G. O'Reilly, S. Wagner, D. J. Franks, K. Cailliau, E. Browaeys, C. Dissous, and L. A. Sabourin (2005)
J. Biol. Chem. 280, 42383-42390
 |  Abstract »  |  Full Text »  |  PDF »

Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells.

A. Tyagi, R. P. Singh, C. Agarwal, S. Siriwardana, R. A. Sclafani, and R. Agarwal (2005)
Carcinogenesis 26, 1978-1987
 |  Abstract »  |  Full Text »  |  PDF »

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.

X. Lu, B. Nannenga, and L. A. Donehower (2005)
Genes & Dev. 19, 1162-1174
 |  Abstract »  |  Full Text »  |  PDF »

Aurora Kinase Inhibitor ZM447439 Blocks Chromosome-induced Spindle Assembly, the Completion of Chromosome Condensation, and the Establishment of the Spindle Integrity Checkpoint in Xenopus Egg Extracts.

B. B. Gadea and J. V. Ruderman (2005)
Mol. Biol. Cell 16, 1305-1318
 |  Abstract »  |  Full Text »  |  PDF »

Hypoxia induces major effects on cell cycle kinetics and protein expression in Drosophila melanogaster embryos.

R. M. Douglas, R. Farahani, P. Morcillo, A. Kanaan, T. Xu, and G. G. Haddad (2005)
Am J Physiol Regulatory Integrative Comp Physiol 288, R511-R521
 |  Abstract »  |  Full Text »  |  PDF »

Characterisation of Cdc25B localisation and nuclear export during the cell cycle and in response to stress.

A. Lindqvist, H. Kallstrom, and C. Karlsson Rosenthal (2004)
J. Cell Sci. 117, 4979-4990
 |  Abstract »  |  Full Text »  |  PDF »

A novel RING-finger-like protein Ini1 is essential for cell cycle progression in fission yeast.

E. Oltra, F. Verde, R. Werner, and G. D'Urso (2004)
J. Cell Sci. 117, 967-974
 |  Abstract »  |  Full Text »  |  PDF »

Wee1-dependent mechanisms required for coordination of cell growth and cell division.

D. R. Kellogg (2003)
J. Cell Sci. 116, 4883-4890
 |  Abstract »  |  Full Text »  |  PDF »

Na-H Exchange-dependent Increase in Intracellular pH Times G2/M Entry and Transition.

L. K. Putney and D. L. Barber (2003)
J. Biol. Chem. 278, 44645-44649
 |  Abstract »  |  Full Text »  |  PDF »

Differential Contribution of Inhibitory Phosphorylation of CDC2 and CDK2 for Unperturbed Cell Cycle Control and DNA Integrity Checkpoints.

J. P. H. Chow, W. Y. Siu, H. T. B. Ho, K. H. T. Ma, C. C. Ho, and R. Y. C. Poon (2003)
J. Biol. Chem. 278, 40815-40828
 |  Abstract »  |  Full Text »  |  PDF »

Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo.

T. Matsuo, S. Yamaguchi, S. Mitsui, A. Emi, F. Shimoda, and H. Okamura (2003)
Science 302, 255-259
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Consensus Motif for Plk (Polo-like Kinase) Phosphorylation Reveals Myt1 as a Plk1 Substrate.

H. Nakajima, F. Toyoshima-Morimoto, E. Taniguchi, and E. Nishida (2003)
J. Biol. Chem. 278, 25277-25280
 |  Abstract »  |  Full Text »  |  PDF »

The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.

B. J. Passer, V. Nancy-Portebois, N. Amzallag, S. Prieur, C. Cans, A. Roborel de Climens, G. Fiucci, V. Bouvard, M. Tuynder, L. Susini, et al. (2003)
PNAS 100, 2284-2289
 |  Abstract »  |  Full Text »  |  PDF »

Hepatitis B Virus X Protein Activates the p38 Mitogen-Activated Protein Kinase Pathway in Dedifferentiated Hepatocytes.

C. Tarn, L. Zou, R. L. Hullinger, and O. M. Andrisani (2002)
J. Virol. 76, 9763-9772
 |  Abstract »  |  Full Text »  |  PDF »

The Epstein-Barr Virus Immediate-Early Protein BZLF1 Induces both a G2 and a Mitotic Block.

A. Mauser, E. Holley-Guthrie, D. Simpson, W. Kaufmann, and S. Kenney (2002)
J. Virol. 76, 10030-10037
 |  Abstract »  |  Full Text »  |  PDF »

Hepatitis B Virus X Protein Differentially Regulates Cell Cycle Progression in X-transforming Versus Nontransforming Hepatocyte (AML12) Cell Lines.

S. Lee, C. Tarn, W.-H. Wang, S. Chen, R. L. Hullinger, and O. M. Andrisani (2002)
J. Biol. Chem. 277, 8730-8740
 |  Abstract »  |  Full Text »  |  PDF »

G2 DNA Damage Checkpoint Inhibition and Antimitotic Activity of 13-Hydroxy-15-oxozoapatlin.

N. T. Rundle, L. Xu, R. J. Andersen, and M. Roberge (2001)
J. Biol. Chem. 276, 48231-48236
 |  Abstract »  |  Full Text »  |  PDF »

14-3-3 Binding Regulates Catalytic Activity of Human Wee1 Kinase.

C. J. Rothblum-Oviatt, C. E. Ryan, and H. Piwnica-Worms (2001)
Cell Growth Differ. 12, 581-589
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the Interaction between p21 and Proliferating Cell Nuclear Antigen for the Maintenance of G2/M Arrest after DNA Damage.

T. Ando, T. Kawabe, H. Ohara, B. Ducommun, M. Itoh, and T. Okamoto (2001)
J. Biol. Chem. 276, 42971-42977
 |  Abstract »  |  Full Text »  |  PDF »

Radiosensitization of p53 Mutant Cells by PD0166285, a Novel G2 Checkpoint Abrogator.

Y. Wang, J. Li, R. N. Booher, A. Kraker, T. Lawrence, W. R. Leopold, and Y. Sun (2001)
Cancer Res. 61, 8211-8217
 |  Abstract »  |  Full Text »  |  PDF »

Positive Regulation of Wee1 by Chk1 and 14-3-3 Proteins.

J. Lee, A. Kumagai, and W. G. Dunphy (2001)
Mol. Biol. Cell 12, 551-563
 |  Abstract »  |  Full Text »

The Cell Cycle Cdc25A Tyrosine Phosphatase Is Activated in Degenerating Postmitotic Neurons in Alzheimer's Disease.

X.-L. Ding, J. Husseman, A. Tomashevski, D. Nochlin, L.-W. Jin, and I. Vincent (2000)
Am. J. Pathol. 157, 1983-1990
 |  Abstract »  |  Full Text »  |  PDF »

p53 Regulation of G2 Checkpoint Is Retinoblastoma Protein Dependent.

P. M. Flatt, L. J. Tang, C. D. Scatena, S. T. Szak, and J. A. Pietenpol (2000)
Mol. Cell. Biol. 20, 4210-4223
 |  Abstract »  |  Full Text »

Binding of 14-3-3{beta} to the Carboxyl Terminus of Wee1 Increases Wee1 Stability, Kinase Activity, and G2-M Cell Population.

Y. Wang, C. Jacobs, K. E. Hook, H. Duan, R. N. Booher, and Y. Sun (2000)
Cell Growth Differ. 11, 211-219
 |  Abstract »  |  Full Text »

The Chk1 Protein Kinase and the Cdc25C Regulatory Pathways Are Targets of the Anticancer Agent UCN-01.

P. R. Graves, L. Yu, J. K. Schwarz, J. Gales, E. A. Sausville, P. M. O'Connor, and H. Piwnica-Worms (2000)
J. Biol. Chem. 275, 5600-5605
 |  Abstract »  |  Full Text »  |  PDF »

Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein.

X. Lei, X Shen, X. Xu, and H. Bernstein (2000)
J. Cell Sci. 113, 4523-4531
 |  Abstract »  |  PDF »

The Disappearance of Cyclins A and B and the Increase in Activity of the G2/M-Phase Cellular Kinase cdc2 in Herpes Simplex Virus 1-Infected Cells Require Expression of the alpha 22/US1.5 and UL13 Viral Genes.

S. J. Advani, R. Brandimarti, R. R. Weichselbaum, and B. Roizman (2000)
J. Virol. 74, 8-15
 |  Abstract »  |  Full Text »

Cdc2 and Cdk2 Kinase Activated by Transforming Growth Factor-beta 1 Trigger Apoptosis through the Phosphorylation of Retinoblastoma Protein in FaO Hepatoma Cells.

K. S. Choi, Y. W. Eom, Y. Kang, M. J. Ha, H. Rhee, J.-W. Yoon, and S.-J. Kim (1999)
J. Biol. Chem. 274, 31775-31783
 |  Abstract »  |  Full Text »  |  PDF »

DNA Damage and Replication Checkpoints in Fission Yeast Require Nuclear Exclusion of the Cdc25 Phosphatase via 14-3-3 Binding.

Y. Zeng and H. Piwnica-Worms (1999)
Mol. Cell. Biol. 19, 7410-7419
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of G2 Arrest in Response to Overexpression of p53.

W. R. Taylor, S. E. DePrimo, A. Agarwal, M. L. Agarwal, A. H. Schönthal, K. S. Katula, and G. R. Stark (1999)
Mol. Biol. Cell 10, 3607-3622
 |  Abstract »  |  Full Text »

The G2 Checkpoint Is Maintained by Redundant Pathways.

T. M. Passalaris, J. A. Benanti, L. Gewin, T. Kiyono, and D. A. Galloway (1999)
Mol. Cell. Biol. 19, 5872-5881
 |  Abstract »  |  Full Text »  |  PDF »

Overproduction of Human Myt1 Kinase Induces a G2 Cell Cycle Delay by Interfering with the Intracellular Trafficking of Cdc2-Cyclin B1 Complexes.

F. Liu, C. Rothblum-Oviatt, C. E. Ryan, and H. Piwnica-Worms (1999)
Mol. Cell. Biol. 19, 5113-5123
 |  Abstract »  |  Full Text »  |  PDF »

Cytoplasmic Localization of Human cdc25C during Interphase Requires an Intact 14-3-3 Binding Site.

S. N. Dalal, C. M. Schweitzer, J. Gan, and J. A. DeCaprio (1999)
Mol. Cell. Biol. 19, 4465-4479
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of maize (Zea mays L.) Wee1 and its activity in developing endosperm.

Y. Sun, B. P. Dilkes, C. Zhang, R. A. Dante, N. P. Carneiro, K. S. Lowe, R. Jung, W. J. Gordon-Kamm, and B. A. Larkins (1999)
PNAS 96, 4180-4185
 |  Abstract »  |  Full Text »  |  PDF »

Mos positively regulates Xe-Wee1 to lengthen the first mitotic cell cycle of Xenopus.

M. S. Murakami, T. D. Copeland, and G. F. Vande Woude (1999)
Genes & Dev. 13, 620-631
 |  Abstract »  |  Full Text »

UCN-01 Abrogates G2 Arrest through a Cdc2-dependent Pathway That Is Associated with Inactivation of the Wee1Hu Kinase and Activation of the Cdc25C Phosphatase.

L. Yu, L. Orlandi, P. Wang, M. S. Orr, A. M. Senderowicz, E. A. Sausville, R. Silvestrini, N. Watanabe, H. Piwnica-Worms, and P. M. O'Connor (1998)
J. Biol. Chem. 273, 33455-33464
 |  Abstract »  |  Full Text »  |  PDF »

Mitotic Phosphorylation of Bcl-2 during Normal Cell Cycle Progression and Taxol-induced Growth Arrest.

C. D. Scatena, Z. A. Stewart, D. Mays, L. J. Tang, C. J. Keefer, S. D. Leach, and J. A. Pietenpol (1998)
J. Biol. Chem. 273, 30777-30784
 |  Abstract »  |  Full Text »  |  PDF »

Human Herpesvirus 7 Infection Induces Profound Cell Cycle Perturbations Coupled to Disregulation of cdc2 and Cyclin B and Polyploidization of CD4+ T Cells.

P. Secchiero, L. Bertolaso, L. Casareto, D. Gibellini, M. Vitale, K. Bemis, A. Aleotti, S. Capitani, G. Franchini, R. C. Gallo, et al. (1998)
Blood 92, 1685-1696
 |  Abstract »  |  Full Text »  |  PDF »

Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase- promoting complex at mitosis.

D. Patra and W. G. Dunphy (1998)
Genes & Dev. 12, 2549-2559
 |  Abstract »  |  Full Text »

Tyrosine Phosphorylation of Cdc2 Is Required for the Replication Checkpoint in Schizosaccharomyces pombe.

N. Rhind and P. Russell (1998)
Mol. Cell. Biol. 18, 3782-3787
 |  Abstract »  |  Full Text »

A Mammalian Homolog of Fission Yeast Cdc5 Regulates G2 Progression and Mitotic Entry.

H. S. Bernstein and S. R. Coughlin (1998)
J. Biol. Chem. 273, 4666-4671
 |  Abstract »  |  Full Text »  |  PDF »

14-3-3 Proteins Act as Negative Regulators of the Mitotic Inducer Cdc25 in Xenopus Egg Extracts.

A. Kumagai, P. S. Yakowec, and W. G. Dunphy (1998)
Mol. Biol. Cell 9, 345-354
 |  Abstract »  |  Full Text »

Analysis of the early embryonic cell cycles of Xenopus; regulation of cell cycle length by Xe-wee1 and Mos.

M. Murakami and G. Vande Woude (1998)
Development 125, 237-248
 |  Abstract »  |  PDF »

A Dual-Specificity Phosphatase Cdc25B Is an Unstable Protein and Triggers p34cdc2/Cyclin B Activation in Hamster BHK21 Cells Arrested with Hydroxyurea.

H. Nishijima, H. Nishitani, T. Seki, and T. Nishimoto (1997)
J. Cell Biol. 138, 1105-1116
 |  Abstract »  |  Full Text »  |  PDF »

Human Myt1 Is a Cell Cycle-regulated Kinase That Inhibits Cdc2 but Not Cdk2 Activity.

R. N. Booher, P. S. Holman, and A. Fattaey (1997)
J. Biol. Chem. 272, 22300-22306
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Schizosaccharomyces pombe Wee1 Tyrosine Kinase.

R. Aligue, L. Wu, and P. Russell (1997)
J. Biol. Chem. 272, 13320-13325
 |  Abstract »  |  Full Text »  |  PDF »

The Protein-tyrosine Kinase Lck Associates with and Is Phosphorylated by Cdc2.

N. I. Pathan, R. L. Geahlen, and M. L. Harrison (1996)
J. Biol. Chem. 271, 27517-27523
 |  Abstract »  |  Full Text »  |  PDF »

Sequential Dephosphorylation of p34cdc2 on Thr-14 and Tyr-15 at the Prophase/Metaphase Transition.

A. Borgne and L. Meijer (1996)
J. Biol. Chem. 271, 27847-27854
 |  Abstract »  |  Full Text »  |  PDF »

Xe-p9, a Xenopus Suc1/Cks homolog, has multiple essential roles in cell cycle control..

D Patra and W G Dunphy (1996)
Genes & Dev. 10, 1503-1515
 |  Abstract »  |  PDF »

Physical and Functional Interactions between Lyn and p34[IMAGE] Kinases in Irradiated Human B-cell Precursors.

F. M. Uckun, L. Tuel-Ahlgren, K. G. Waddick, X. Jun, J. Jin, D. E. Myers, R. B. Rowley, A. L. Burkhardt, and J. B. Bolen (1996)
J. Biol. Chem. 271, 6389-6397
 |  Abstract »  |  Full Text »  |  PDF »

Demonstration of Cyclin-dependent Kinase Inhibitory Serine/Threonine Kinase in Bovine Thymus.

I. Matsuura and J. H. Wang (1996)
J. Biol. Chem. 271, 5443-5450
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Casein Kinase II by p34[IMAGE].

D. G. Bosc, E. Slominski, C. Sichler, and D. W. Litchfield (1995)
J. Biol. Chem. 270, 25872-25878
 |  Abstract »  |  Full Text »  |  PDF »

Purification of a 12,020-Dalton Protein That Enhances the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase.

A. Scott, C. M. M. Haystead, and T. A. J. Haystead (1995)
J. Biol. Chem. 270, 24540-24547
 |  Abstract »  |  Full Text »  |  PDF »

Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15.

P. R. Mueller, T. R. Coleman, A. Kumagai, and W. G. Dunphy (1995)
Science 270, 86-90
 |  Abstract »  |  PDF »

Response.

A. H. Greenberg and D. W. Litchfield (1995)
Science 269, 107
 |  PDF »

Reconstitution of Neuronal Cdc2-like Kinase from Bacteria-expressed Cdk5 and an Active Fragment of the Brain-specific Activator.

Z. Qi, Q.-Q. Huang, K.-Y. Lee, J. Lew, and J. H. Wang (1995)
J. Biol. Chem. 270, 10847-10854
 |  Abstract »  |  Full Text »  |  PDF »

Subcellular localisation of human wee1 kinase is regulated during the cell cycle.

V Baldin and B Ducommun (1995)
J. Cell Sci. 108, 2425-2432
 |  Abstract »  |  PDF »

Negative regulation of mitosis by the fission yeast protein phosphatase ppa2..

N Kinoshita, H Yamano, H Niwa, T Yoshida, and M Yanagida (1993)
Genes & Dev. 7, 1059-1071
 |  Abstract »  |  PDF »

NF-Y Mediates the Transcriptional Inhibition of the cyclin B1, cyclin B2, and cdc25C Promoters upon Induced G2 Arrest.

I. Manni, G. Mazzaro, A. Gurtner, R. Mantovani, U. Haugwitz, K. Krause, K. Engeland, A. Sacchi, S. Soddu, and G. Piaggio (2001)
J. Biol. Chem. 276, 5570-5576
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine.

D. Curman, B. Cinel, D. E. Williams, N. Rundle, W. D. Block, A. A. Goodarzi, J. R. Hutchins, P. R. Clarke, B.-B. Zhou, S. P. Lees-Miller, et al. (2001)
J. Biol. Chem. 276, 17914-17919
 |  Abstract »  |  Full Text »  |  PDF »

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