Science 18 September 1992: Vol. 257. no. 5077, pp. 1685 - 1689 DOI: 10.1126/science.1382315

Prev | Table of Contents | Next

Articles

Tumor Suppression by PTEN Requires the Activation of the PKR-eIF2{alpha} Phosphorylation Pathway.

Z. Mounir, J. L. Krishnamoorthy, G. P. Robertson, D. Scheuner, R. J. Kaufman, M.-M. Georgescu, and A. E. Koromilas (2009)
Science Signaling 2, ra85
 |  Abstract »  |  Full Text »  |  PDF »

Eukaryotic Initiation Factors (eIF) 2{alpha} and 4E Expression, Localization, and Phosphorylation in Brain Tumors.

S. Tejada, M. V. T. Lobo, M. Garcia-Villanueva, S. Sacristan, M. I. Perez-Morgado, M. Salinas, and M. E. Martin (2009)
J. Histochem. Cytochem. 57, 503-512
 |  Abstract »  |  Full Text »  |  PDF »

Reduced Eukaryotic Initiation Factor 2B{varepsilon}-Subunit Expression Suppresses the Transformed Phenotype of Cells Overexpressing the Protein.

J. W. Gallagher, N. Kubica, S. R. Kimball, and L. S. Jefferson (2008)
Cancer Res. 68, 8752-8760
 |  Abstract »  |  Full Text »  |  PDF »

An Oncogenic Role for the Phosphorylated h-Subunit of Human Translation Initiation Factor eIF3.

L. Zhang, Z. Smit-McBride, X. Pan, J. Rheinhardt, and J. W. B. Hershey (2008)
J. Biol. Chem. 283, 24047-24060
 |  Abstract »  |  Full Text »  |  PDF »

Functional Domains and the Antiviral Effect of the Double-Stranded RNA-Dependent Protein Kinase PKR from Paralichthys olivaceus.

R. Zhu, Y.-B. Zhang, Q.-Y. Zhang, and J.-F. Gui (2008)
J. Virol. 82, 6889-6901
 |  Abstract »  |  Full Text »  |  PDF »

Translational Control of C-terminal Src Kinase (Csk) Expression by PRL3 Phosphatase.

F. Liang, Y. Luo, Y. Dong, C. D. Walls, J. Liang, H.-Y. Jiang, J. R. Sanford, R. C. Wek, and Z.-Y. Zhang (2008)
J. Biol. Chem. 283, 10339-10346
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR.

M. Mittelstadt, A. Frump, T. Khuu, V. Fowlkes, I. Handy, C. V. Patel, and R. C. Patel (2008)
Nucleic Acids Res. 36, 998-1008
 |  Abstract »  |  Full Text »  |  PDF »

Control of virus infection by tumour suppressors.

C. Munoz-Fontela, M. A. Garcia, M. Collado, L. Marcos-Villar, P. Gallego, M. Esteban, and C. Rivas (2007)
Carcinogenesis 28, 1140-1144
 |  Abstract »  |  Full Text »  |  PDF »

Skeletal Muscle Atrophy, a Link between Depression of Protein Synthesis and Increase in Degradation.

H. L. Eley and M. J. Tisdale (2007)
J. Biol. Chem. 282, 7087-7097
 |  Abstract »  |  Full Text »  |  PDF »

Individual Overexpression of Five Subunits of Human Translation Initiation Factor eIF3 Promotes Malignant Transformation of Immortal Fibroblast Cells.

L. Zhang, X. Pan, and J. W. B. Hershey (2007)
J. Biol. Chem. 282, 5790-5800
 |  Abstract »  |  Full Text »  |  PDF »

Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action.

M. A. Garcia, J. Gil, I. Ventoso, S. Guerra, E. Domingo, C. Rivas, and M. Esteban (2006)
Microbiol. Mol. Biol. Rev. 70, 1032-1060
 |  Abstract »  |  Full Text »  |  PDF »

Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification.

S. Puthenveetil, L. Whitby, J. Ren, K. Kelnar, J. F. Krebs, and P. A. Beal (2006)
Nucleic Acids Res. 34, 4900-4911
 |  Abstract »  |  Full Text »  |  PDF »

RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection.

R. L. Bennett, W. L. Blalock, D. M. Abtahi, Y. Pan, S. A. Moyer, and W. S. May (2006)
Blood 108, 821-829
 |  Abstract »  |  Full Text »  |  PDF »

Double-stranded RNA-dependent Protein Kinase Phosphorylation of the {alpha}-Subunit of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis.

D. Scheuner, R. Patel, F. Wang, K. Lee, K. Kumar, J. Wu, A. Nilsson, M. Karin, and R. J. Kaufman (2006)
J. Biol. Chem. 281, 21458-21468
 |  Abstract »  |  Full Text »  |  PDF »

Human Gene Profiling in Response to the Active Protein Kinase, Interferon-induced Serine/threonine Protein Kinase (PKR), in Infected Cells: INVOLVEMENT OF THE TRANSCRIPTION FACTOR ATF-3 IN PKR-INDUCED APOPTOSIS.

S. Guerra, L. A. Lopez-Fernandez, M. A. Garcia, A. Zaballos, and M. Esteban (2006)
J. Biol. Chem. 281, 18734-18745
 |  Abstract »  |  Full Text »  |  PDF »

Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha} RNA-dependent protein kinase..

Q. Su, S. Wang, D. Baltzis, L.-K. Qu, A. H.-T. Wong, and A. E. Koromilas (2006)
PNAS 103, 63-68
 |  Abstract »  |  Full Text »  |  PDF »

Protection from Interferon-Induced Apoptosis by Epstein-Barr Virus Small RNAs Is Not Mediated by Inhibition of PKR.

I. K. Ruf, K. A. Lackey, S. Warudkar, and J. T. Sample (2005)
J. Virol. 79, 14562-14569
 |  Abstract »  |  Full Text »  |  PDF »

Serine 18 Phosphorylation of RAX, the PKR Activator, Is Required for PKR Activation and Consequent Translation Inhibition.

R. L. Bennett, W. L. Blalock, and W. S. May (2004)
J. Biol. Chem. 279, 42687-42693
 |  Abstract »  |  Full Text »  |  PDF »

Nucleophosmin Interacts with and Inhibits the Catalytic Function of Eukaryotic Initiation Factor 2 Kinase PKR.

Q. Pang, T. A. Christianson, T. Koretsky, H. Carlson, L. David, W. Keeble, G. R. Faulkner, A. Speckhart, and G. C. Bagby (2003)
J. Biol. Chem. 278, 41709-41717
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Role for RAX, the Cellular Activator of PKR, in Synergistically Stimulating SV40 Large T Antigen-dependent Gene Expression.

M. Yang, T. Ito, and W. S. May (2003)
J. Biol. Chem. 278, 38325-38332
 |  Abstract »  |  Full Text »  |  PDF »

The dsRNA binding protein family: critical roles, diverse cellular functions.

L. R. SAUNDERS and G. N. BARBER (2003)
FASEB J 17, 961-983
 |  Abstract »  |  Full Text »  |  PDF »

Translational control of SCL-isoform expression in hematopoietic lineage choice.

C. F. Calkhoven, C. Muller, R. Martin, G. Krosl, T. Hoang, and A. Leutz (2003)
Genes & Dev. 17, 959-964
 |  Abstract »  |  Full Text »  |  PDF »

RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis.

A. OGURO, T. OHTSU, Y. V. SVITKIN, N. SONENBERG, and Y. NAKAMURA (2003)
RNA 9, 394-407
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2{alpha}.

C. Koumenis, C. Naczki, M. Koritzinsky, S. Rastani, A. Diehl, N. Sonenberg, A. Koromilas, and B. G. Wouters (2002)
Mol. Cell. Biol. 22, 7405-7416
 |  Abstract »  |  Full Text »  |  PDF »

PKR-Dependent Mechanisms of Gene Expression from a Subgenomic Hepatitis C Virus Clone.

A. M. Rivas-Estilla, Y. Svitkin, M. Lopez Lastra, M. Hatzoglou, A. Sherker, and A. E. Koromilas (2002)
J. Virol. 76, 10637-10653
 |  Abstract »  |  Full Text »  |  PDF »

The Direct Binding of the Catalytic Subunit of Protein Phosphatase 1 to the PKR Protein Kinase Is Necessary but Not Sufficient for Inactivation and Disruption of Enzyme Dimer Formation.

S.-L. Tan, S. U. Tareen, M. W. Melville, C. M. Blakely, and M. G. Katze (2002)
J. Biol. Chem. 277, 36109-36117
 |  Abstract »  |  Full Text »  |  PDF »

Proapoptotic protein PACT is expressed at high levels in colonic epithelial cells in mice.

V. Gupta and R. C. Patel (2002)
Am J Physiol Gastrointest Liver Physiol 283, G801-G808
 |  Abstract »  |  Full Text »  |  PDF »

Contribution of Double-Stranded RNA-Activated Protein Kinase Toward Antiproliferative Actions of Heparin on Vascular Smooth Muscle Cells.

R. C. Patel, I. Handy, and C. V. Patel (2002)
Arterioscler Thromb Vasc Biol 22, 1439-1444
 |  Abstract »  |  Full Text »  |  PDF »

The 3'-untranslated regions of cytoskeletal muscle mRNAs inhibit translation by activating the double-stranded RNA-dependent protein kinase PKR.

J. M. Nussbaum, S. Gunnery, and M. B. Mathews (2002)
Nucleic Acids Res. 30, 1205-1212
 |  Abstract »  |  Full Text »  |  PDF »

MC159L protein from the poxvirus molluscum contagiosum virus inhibits NF-{kappa}B activation and apoptosis induced by PKR.

J. Gil, J. Rullas, J. Alcami, and M. Esteban (2001)
J. Gen. Virol. 82, 3027-3034
 |  Abstract »  |  Full Text »  |  PDF »

Antiviral Actions of Interferons.

C. E. Samuel (2001)
Clin. Microbiol. Rev. 14, 778-809
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of the RNA-dependent protein kinase regulates its RNA-binding activity.

N. V. Jammi and P. A. Beal (2001)
Nucleic Acids Res. 29, 3020-3029
 |  Abstract »  |  Full Text »  |  PDF »

Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2.

F. L. Erickson, J. Nika, S. Rippel, and E. M. Hannig (2001)
Genetics 158, 123-132
 |  Abstract »  |  Full Text »

Role of double-stranded RNA-dependent protein kinase in mediating hypersensitivity of Fanconi anemia complementation group C cells to interferon {gamma}, tumor necrosis factor-{alpha}, and double-stranded RNA.

Q. Pang, W. Keeble, J. Diaz, T. A. Christianson, S. Fagerlie, K. Rathbun, G. R. Faulkner, M. O'Dwyer, and G. C. Bagby Jr (2001)
Blood 97, 1644-1652
 |  Abstract »  |  Full Text »  |  PDF »

Latently Expressed Human Herpesvirus 8-Encoded Interferon Regulatory Factor 2 Inhibits Double-Stranded RNA-Activated Protein Kinase.

L. Burysek and P. M. Pitha (2001)
J. Virol. 75, 2345-2352
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis is promoted by the dsRNA-activated factor (DRAF1) during viral infection independent of the action of interferon or p53.

B. K. WEAVER, O. ANDO, K. P. KUMAR, and N. C. REICH (2001)
FASEB J 15, 501-515
 |  Abstract »  |  Full Text »  |  PDF »

Negative Regulation of CD8+ T Cell Function by the IFN-Induced and Double-Stranded RNA-Activated Kinase PKR.

S. Kadereit, H. Xu, T. M. Engeman, Y.-L. Yang, R. L. Fairchild, and B. R. G. Williams (2000)
J. Immunol. 165, 6896-6901
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the Interferon-inducible Double-Stranded RNA-dependent Protein Kinase as a Regulator of Cellular Response to Bulky Adducts.

J. Bergeron, N. Benlimame, N. Zeng-Rong, D. Xiao, P. J. Scrivens, A. E. Koromilas, and M. A. Alaoui-Jamali (2000)
Cancer Res. 60, 6800-6804
 |  Abstract »  |  Full Text »

Epstein-Barr Virus Small RNAs Potentiate Tumorigenicity of Burkitt Lymphoma Cells Independently of an Effect on Apoptosis.

I. K. Ruf, P. W. Rhyne, C. Yang, J. L. Cleveland, and J. T. Sample (2000)
J. Virol. 74, 10223-10228
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2alpha kinase.

J. S. Crosby, P. J. Chefalo, I. Yeh, S. Ying, I. M. London, P. Leboulch, and J.-J. Chen (2000)
Blood 96, 3241-3248
 |  Abstract »  |  Full Text »  |  PDF »

Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures.

S. Goodbourn, L. Didcock, and R. E. Randall (2000)
J. Gen. Virol. 81, 2341-2364
 |  Full Text »

Translational control of C/EBPalpha and C/EBPbeta isoform expression.

C. F. Calkhoven, C. Müller, and A. Leutz (2000)
Genes & Dev. 14, 1920-1932
 |  Abstract »  |  Full Text »

The B56alpha Regulatory Subunit of Protein Phosphatase 2A Is a Target for Regulation by Double-Stranded RNA-Dependent Protein Kinase PKR.

Z. Xu and B. R. G. Williams (2000)
Mol. Cell. Biol. 20, 5285-5299
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Hepatitis C Virus Proteins Interferes with the Antiviral Action of Interferon Independently of PKR-Mediated Control of Protein Synthesis.

C. Francois, G. Duverlie, D. Rebouillat, H. Khorsi, S. Castelain, H. E. Blum, A. Gatignol, C. Wychowski, D. Moradpour, and E. F. Meurs (2000)
J. Virol. 74, 5587-5596
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Translation Initiation Mediates the Anticancer Effect of the n-3 Polyunsaturated Fatty Acid Eicosapentaenoic Acid.

S. S. Palakurthi, R. Fluckiger, H. Aktas, A. K. Changolkar, A. Shahsafaei, S. Harneit, E. Kilic, and J. A. Halperin (2000)
Cancer Res. 60, 2919-2925
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Caspase 3-mediated Cleavage and Functional Alteration of Eukaryotic Initiation Factor 2alpha in Apoptosis.

W. E. Marissen, Y. Guo, A. A. M. Thomas, R. L. Matts, and R. E. Lloyd (2000)
J. Biol. Chem. 275, 9314-9323
 |  Abstract »  |  Full Text »  |  PDF »

A new double-stranded RNA-binding protein that interacts with PKR.

C. J. Coolidge and J. G. Patton (2000)
Nucleic Acids Res. 28, 1407-1417
 |  Abstract »  |  Full Text »  |  PDF »

NF-kappa B Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF-kappa B-Inducing Kinase and Ikappa B Kinase.

M. Zamanian-Daryoush, T. H. Mogensen, J. A. DiDonato, and B. R. G. Williams (2000)
Mol. Cell. Biol. 20, 1278-1290
 |  Abstract »  |  Full Text »  |  PDF »

Induction of E-Selectin Expression by Double-Stranded RNA and TNF-{alpha} Is Attenuated in Murine Aortic Endothelial Cells Derived from Double-Stranded RNA-Activated Kinase (PKR)-Null Mice.

S. K. Bandyopadhyay, C. A. de la Motte, and B. R. G. Williams (2000)
J. Immunol. 164, 2077-2083
 |  Abstract »  |  Full Text »  |  PDF »

Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway.

S. Balachandran, P. C. Roberts, T. Kipperman, K. N. Bhalla, R. W. Compans, D. R. Archer, and G. N. Barber (2000)
J. Virol. 74, 1513-1523
 |  Abstract »  |  Full Text »  |  PDF »

A Mammalian Homologue of GCN2 Protein Kinase Important for Translational Control by Phosphorylation of Eukaryotic Initiation Factor-2{alpha}.

R. Sood, A. C. Porter, D. Olsen, D. R. Cavener, and R. C. Wek (2000)
Genetics 154, 787-801
 |  Abstract »  |  Full Text »

A cis-acting element in the 3'-untranslated region of human TNF-alpha mRNA renders splicing dependent on the activation of protein kinase PKR.

F. Osman, N. Jarrous, Y. Ben-Asouli, and R. Kaempfer (1999)
Genes & Dev. 13, 3280-3293
 |  Abstract »  |  Full Text »

Oncogenic Role of Epstein-Barr Virus-Encoded RNAs in Burkitt's Lymphoma Cell Line Akata.

J. Komano, S. Maruo, K. Kurozumi, T. Oda, and K. Takada (1999)
J. Virol. 73, 9827-9831
 |  Abstract »  |  Full Text »  |  PDF »

Interferon-inducible Gene Family 1-8U Expression in Colitis-associated Colon Cancer and Severely Inflamed Mucosa in Ulcerative Colitis.

T. Hisamatsu, M. Watanabe, H. Ogata, T. Ezaki, S. Hozawa, H. Ishii, T. Kanai, and T. Hibi (1999)
Cancer Res. 59, 5927-5931
 |  Abstract »  |  Full Text »  |  PDF »

The Interferon-induced Double-stranded RNA-activated Protein Kinase PKR Will Phosphorylate Serine, Threonine, or Tyrosine at Residue 51 in Eukaryotic Initiation Factor 2alpha.

J. Lu, E. B. O'Hara, B. A. Trieselmann, P. R. Romano, and T. E. Dever (1999)
J. Biol. Chem. 274, 32198-32203
 |  Abstract »  |  Full Text »  |  PDF »

Antiapoptotic and Oncogenic Potentials of Hepatitis C Virus Are Linked to Interferon Resistance by Viral Repression of the PKR Protein Kinase.

M. Gale Jr., B. Kwieciszewski, M. Dossett, H. Nakao, and M. G. Katze (1999)
J. Virol. 73, 6506-6516
 |  Abstract »  |  Full Text »  |  PDF »

DRBP76, a Double-stranded RNA-binding Nuclear Protein, Is Phosphorylated by the Interferon-induced Protein Kinase, PKR.

R. C. Patel, D. J. Vestal, Z. Xu, S. Bandyopadhyay, W. Guo, S. M. Erme, B. R. G. Williams, and G. C. Sen (1999)
J. Biol. Chem. 274, 20432-20437
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Double-Stranded RNA- and Tumor Necrosis Factor Alpha-Mediated Apoptosis by Tetratricopeptide Repeat Protein and Cochaperone P58IPK.

N. M. Tang, M. J. Korth, M. Gale Jr., M. Wambach, S. D. Der, S. K. Bandyopadhyay, B. R. G. Williams, and M. G. Katze (1999)
Mol. Cell. Biol. 19, 4757-4765
 |  Abstract »  |  Full Text »  |  PDF »

Translational Homeostasis: Eukaryotic Translation Initiation Factor 4E Control of 4E-Binding Protein 1 and p70 S6 Kinase Activities.

K. Khaleghpour, S. Pyronnet, A.-C. Gingras, and N. Sonenberg (1999)
Mol. Cell. Biol. 19, 4302-4310
 |  Abstract »  |  Full Text »  |  PDF »

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.

R. J. Kaufman (1999)
Genes & Dev. 13, 1211-1233
 |  Full Text »

Double-Stranded-RNA-Activated Protein Kinase PKR Enhances Transcriptional Activation by Tumor Suppressor p53.

A. R. Cuddihy, S. Li, N. W. N. Tam, A. H.-T. Wong, Y. Taya, N. Abraham, J. C. Bell, and A. E. Koromilas (1999)
Mol. Cell. Biol. 19, 2475-2484
 |  Abstract »  |  Full Text »  |  PDF »

Epstein-Barr Virus Regulates c-MYC, Apoptosis, and Tumorigenicity in Burkitt Lymphoma.

I. K. Ruf, P. W. Rhyne, H. Yang, C. M. Borza, L. M. Hutt-Fletcher, J. L. Cleveland, and J. T. Sample (1999)
Mol. Cell. Biol. 19, 1651-1660
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of PKR in the Regulation of Myogenesis.

Y. Kronfeld-Kinar, S. Vilchik, T. Hyman, F. Leibkowicz, and S. Salzberg (1999)
Cell Growth Differ. 10, 201-212
 |  Abstract »  |  Full Text »

Characterization of Transgenic Mice with Targeted Disruption of the Catalytic Domain of the Double-stranded RNA-dependent Protein Kinase, PKR.

N. Abraham, D. F. Stojdl, P. I. Duncan, N. Methot, T. Ishii, M. Dube, B. C. Vanderhyden, H. L. Atkins, D. A. Gray, M. W. McBurney, et al. (1999)
J. Biol. Chem. 274, 5953-5962
 |  Abstract »  |  Full Text »  |  PDF »

The Cellular Inhibitor of the PKR Protein Kinase, P58IPK, Is an Influenza Virus-activated Co-chaperone That Modulates Heat Shock Protein 70 Activity.

M. W. Melville, S.-L. Tan, M. Wambach, J. Song, R. I. Morimoto, and M. G. Katze (1999)
J. Biol. Chem. 274, 3797-3803
 |  Abstract »  |  Full Text »  |  PDF »

Epstein-Barr Virus Promotes Epithelial Cell Growth in the Absence of EBNA2 and LMP1 Expression.

J. Nishikawa, S. Imai, T. Oda, T. Kojima, K. Okita, and K. Takada (1999)
J. Virol. 73, 1286-1292
 |  Abstract »  |  Full Text »  |  PDF »

Double-Stranded RNA-Activated Protein Kinase (PKR) Is Negatively Regulated by 60S Ribosomal Subunit Protein L18.

K. U. Kumar, S. P. Srivastava, and R. J. Kaufman (1999)
Mol. Cell. Biol. 19, 1116-1125
 |  Abstract »  |  Full Text »  |  PDF »

Yeast Proteins Related to the p40/Laminin Receptor Precursor Are Required for 20S Ribosomal RNA Processing and the Maturation of 40S Ribosomal Subunits.

C. L. Ford, L. Randal-Whitis, and S. R. Ellis (1999)
Cancer Res. 59, 704-710
 |  Abstract »  |  Full Text »  |  PDF »

Requirement of PKR Dimerization Mediated by Specific Hydrophobic Residues for Its Activation by Double-Stranded RNA and Its Antigrowth Effects in Yeast.

R. C. Patel and G. C. Sen (1998)
Mol. Cell. Biol. 18, 7009-7019
 |  Abstract »  |  Full Text »  |  PDF »

Highly Conserved RNA Sequences That Are Sensors of Environmental Stress.

A. Spicher, O. M. Guicherit, L. Duret, A. Aslanian, E. M. Sanjines, N. C. Denko, A. J. Giaccia, and H. M. Blau (1998)
Mol. Cell. Biol. 18, 7371-7382
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 alpha -Subunit Kinase, PEK, Involved in Translational Control.

Y. Shi, K. M. Vattem, R. Sood, J. An, J. Liang, L. Stramm, and R. C. Wek (1998)
Mol. Cell. Biol. 18, 7499-7509
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Hemin-sensitive Eukaryotic Initiation Factor 2alpha Kinase from Mouse Nonerythroid Cells.

J. J. Berlanga, S. Herrero, and C. de Haro (1998)
J. Biol. Chem. 273, 32340-32346
 |  Abstract »  |  Full Text »  |  PDF »

c-Myc Is a Major Mediator of the Synergistic Growth Inhibitory Effects of Retinoic Acid and Interferon in Breast Cancer Cells.

Y. Shang, C. R. Baumrucker, and M. H. Green (1998)
J. Biol. Chem. 273, 30608-30613
 |  Abstract »  |  Full Text »  |  PDF »

Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation.

M. Gale Jr., C. M. Blakely, B. Kwieciszewski, S.-L. Tan, M. Dossett, N. M. Tang, M. J. Korth, S. J. Polyak, D. R. Gretch, and M. G. Katze (1998)
Mol. Cell. Biol. 18, 5208-5218
 |  Abstract »  |  Full Text »  |  PDF »

Depletion of intracellular Ca2+ stores, phosphorylation of eIF2alpha , and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole.

H. Aktas, R. Fluckiger, J. A. Acosta, J. M. Savage, S. S. Palakurthi, and J. A. Halperin (1998)
PNAS 95, 8280-8285
 |  Abstract »  |  Full Text »  |  PDF »

Double-Stranded RNA-Independent Dimerization of Interferon-Induced Protein Kinase PKR and Inhibition of Dimerization by the Cellular P58IPK Inhibitor.

S.-L. Tan, M. J. Gale Jr., and M. G. Katze (1998)
Mol. Cell. Biol. 18, 2431-2443
 |  Abstract »  |  Full Text »  |  PDF »

Mutations in the Double-stranded RNA-activated Protein Kinase Insert Region That Uncouple Catalysis from eIF2alpha Binding.

R. Cai and B. R. G. Williams (1998)
J. Biol. Chem. 273, 11274-11280
 |  Abstract »  |  Full Text »  |  PDF »

Disruption of cellular translational control by a viral truncated eukaryotic translation initiation factor 2alpha kinase homolog.

T. E. Dever, R. Sripriya, J. R. McLachlin, J. Lu, J. R. Fabian, S. R. Kimball, and L. K. Miller (1998)
PNAS 95, 4164-4169
 |  Abstract »  |  Full Text »  |  PDF »

Autophosphorylation in the Activation Loop Is Required for Full Kinase Activity In Vivo of Human and Yeast Eukaryotic Initiation Factor 2alpha Kinases PKR and GCN2.

P. R. Romano, M. T. Garcia-Barrio, X. Zhang, Q. Wang, D. R. Taylor, F. Zhang, C. Herring, M. B. Mathews, J. Qin, and A. G. Hinnebusch (1998)
Mol. Cell. Biol. 18, 2282-2297
 |  Abstract »  |  Full Text »  |  PDF »

Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 Are Subunits of Double-Stranded RNA-Activated Transcription Factor DRAF1.

B. K. Weaver, K. P. Kumar, and N. C. Reich (1998)
Mol. Cell. Biol. 18, 1359-1368
 |  Abstract »  |  Full Text »  |  PDF »

Translational control: a general mechanism for gene regulation during T cell activation.

J. A. Garcia-Sanz, W. Mikulits, A. Livingstone, I. Lefkovits, and E. W. Müllner (1998)
FASEB J 12, 299-306
 |  Abstract »  |  Full Text »

Regulation of Interferon-Induced Protein Kinase PKR: Modulation of P58IPK Inhibitory Function by a Novel Protein, P52rIPK.

M. Gale Jr., C. M. Blakely, D. A. Hopkins, M. W. Melville, M. Wambach, P. R. Romano, and M. G. Katze (1998)
Mol. Cell. Biol. 18, 859-871
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis in Response to Activation of the Double-stranded RNA-dependent Protein Kinase.

S. P. Srivastava, K. U. Kumar, and R. J. Kaufman (1998)
J. Biol. Chem. 273, 2416-2423
 |  Abstract »  |  Full Text »  |  PDF »

Ribosome-binding Domain of Eukaryotic Initiation Factor-2 Kinase GCN2 Facilitates Translation Control.

S. Zhu and R. C. Wek (1998)
J. Biol. Chem. 273, 1808-1814
 |  Abstract »  |  Full Text »  |  PDF »

The Translation Initiation Factor eIF3-p48 Subunit Is Encoded by int-6, a Site of Frequent Integration by the Mouse Mammary Tumor Virus Genome.

K. Asano, W. C. Merrick, and J. W. B. Hershey (1997)
J. Biol. Chem. 272, 23477-23480
 |  Abstract »  |  Full Text »  |  PDF »

KIS Is a Protein Kinase with an RNA Recognition Motif.

A. Maucuer, S. Ozon, V. Manceau, O. Gavet, S. Lawler, P. Curmi, and A. Sobel (1997)
J. Biol. Chem. 272, 23151-23156
 |  Abstract »  |  Full Text »  |  PDF »

New Advances in Interferon Therapy of Cancer.

S. Wadler and E. L. Schwartz (1997)
Oncologist 2, 254-267
 |  Abstract »  |  Full Text »  |  PDF »

Ribosome Targeting of PKR Is Mediated by Two Double-stranded RNA-binding Domains and Facilitates in Vivo Phosphorylation of Eukaryotic Initiation Factor-2.

S. Zhu, P. R. Romano, and R. C. Wek (1997)
J. Biol. Chem. 272, 14434-14441
 |  Abstract »  |  Full Text »  |  PDF »

Cloning and Characterization of a cDNA Encoding a Protein Synthesis Initiation Factor-2alpha (eIF-2alpha ) Kinase from Drosophila melanogaster. HOMOLOGY TO YEAST GCN2 PROTEIN KINASE.

J. Santoyo, J. Alcalde, R. Mendez, D. Pulido, and C. de Haro (1997)
J. Biol. Chem. 272, 12544-12550
 |  Abstract »  |  Full Text »  |  PDF »

The Tat Protein of Human Immunodeficiency Virus Type 1Is a Substrate and Inhibitor of the Interferon-induced, Virally Activated Protein Kinase, PKR.

S. R. Brand, R. Kobayashi, and M. B. Mathews (1997)
J. Biol. Chem. 272, 8388-8395
 |  Abstract »  |  Full Text »  |  PDF »

A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme..

S Yamanaka, K S Poksay, K S Arnold, and T L Innerarity (1997)
Genes & Dev. 11, 321-333
 |  Abstract »  |  PDF »

A Model for the Double-stranded RNA (dsRNA)-dependent Dimerization and Activation of the dsRNA-activated Protein Kinase PKR.

S. Wu and R. J. Kaufman (1997)
J. Biol. Chem. 272, 1291-1296
 |  Abstract »  |  Full Text »  |  PDF »

The molecular chaperone hsp40 regulates the activity of P58IPK, the cellular inhibitor of PKR.

M. W. Melville, W. J. Hansen, B. C. Freeman, W. J. Welch, and M. G. Katze (1997)
PNAS 94, 97-102
 |  Abstract »  |  Full Text »  |  PDF »

The 58-kDa Cellular Inhibitor of the Double Stranded RNA-dependent Protein Kinase Requires the Tetratricopeptide Repeat 6 and DnaJ Motifs to Stimulate Protein Synthesis in Vivo.

N. M. Tang, C. Y. Ho, and M. G. Katze (1996)
J. Biol. Chem. 271, 28660-28666
 |  Abstract »  |  Full Text »  |  PDF »

Double-stranded RNA-dependent Protein Kinase Mediates c-Myc Suppression Induced by Type I Interferons.

T. Raveh, A. G. Hovanessian, E. F. Meurs, N. Sonenberg, and A. Kimchi (1996)
J. Biol. Chem. 271, 25479-25484
 |  Abstract »  |  Full Text »  |  PDF »

Specific Mutations Near the Amino Terminus of Double-stranded RNA-dependent Protein Kinase (PKR) Differentially Affect Its Double-stranded RNA Binding and Dimerization Properties.

R. C. Patel, P. Stanton, and G. C. Sen (1996)
J. Biol. Chem. 271, 25657-25663
 |  Abstract »  |  Full Text »  |  PDF »

The Kinase Insert Domain of Interferon-induced Protein Kinase PKR Is Required for Activity but Not for Interaction with the Pseudosubstrate K3L.

A. W.B. Craig, G. P. Cosentino, O. Donze, and N. Sonenberg (1996)
J. Biol. Chem. 271, 24526-24533
 |  Abstract »  |  Full Text »  |  PDF »

Histidyl-tRNA Synthetase-related Sequences in GCN2 Protein Kinase Regulate in Vitro Phosphorylation of eIF-2.

S. Zhu, A. Y. Sobolev, and R. C. Wek (1996)
J. Biol. Chem. 271, 24989-24994
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products