Science 4 September 1992: Vol. 257. no. 5075, pp. 1404 - 1407 DOI: 10.1126/science.1326789

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Articles

Keep Nibbling at the Edges.

P. Cohen (2009)
J. Biol. Chem. 284, 23891-23901
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Inhibition of Raf-1 Alters Multiple Downstream Pathways to Induce Pancreatic -Cell Apoptosis.

E. U. Alejandro and J. D. Johnson (2008)
J. Biol. Chem. 283, 2407-2417
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Radiation-induced cell signaling: inside-out and outside-in.

K. Valerie, A. Yacoub, M. P. Hagan, D. T. Curiel, P. B. Fisher, S. Grant, and P. Dent (2007)
Mol. Cancer Ther. 6, 789-801
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Inhibition of Tumor Endothelial ERK Activation, Angiogenesis, and Tumor Growth by Sorafenib (BAY43-9006).

D. A. Murphy, S. Makonnen, W. Lassoued, M. D. Feldman, C. Carter, and W. M.F. Lee (2006)
Am. J. Pathol. 169, 1875-1885
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Raf: A Strategic Target for Therapeutic Development Against Cancer.

M. Beeram, A. Patnaik, and E. K. Rowinsky (2005)
J. Clin. Oncol. 23, 6771-6790
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A critical function for B-Raf at multiple stages of myelopoiesis.

T. Kamata, J. Kang, T.-H. Lee, L. Wojnowski, C. A. Pritchard, and A. D. Leavitt (2005)
Blood 106, 833-840
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Mitogen-Activated Protein Kinase Feedback Phosphorylation Regulates MEK1 Complex Formation and Activation during Cellular Adhesion.

S. T. Eblen, J. K. Slack-Davis, A. Tarcsafalvi, J. T. Parsons, M. J. Weber, and A. D. Catling (2004)
Mol. Cell. Biol. 24, 2308-2317
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The Cyclin-dependent Kinase Inhibitor CYC202 (R-Roscovitine) Inhibits Retinoblastoma Protein Phosphorylation, Causes Loss of Cyclin D1, and Activates the Mitogen-activated Protein Kinase Pathway.

S. R. Whittaker, M. I. Walton, M. D. Garrett, and P. Workman (2004)
Cancer Res. 64, 262-272
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Farnesyltransferase inhibitors in hematologic malignancies: new horizons in therapy.

J. E. Lancet and J. E. Karp (2003)
Blood 102, 3880-3889
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The COOH-Terminal Domain of Wild-Type Cot Regulates Its Stability and Kinase Specific Activity.

M. L. Gandara, P. Lopez, R. Hernando, J. G. Castano, and S. Alemany (2003)
Mol. Cell. Biol. 23, 7377-7390
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Map kinase signaling pathways and hematologic malignancies.

L. C. Platanias (2003)
Blood 101, 4667-4679
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The Hepatitis C Virus Non-structural NS5A Protein Inhibits Activating Protein-1 Function by Perturbing Ras-ERK Pathway Signaling.

A. Macdonald, K. Crowder, A. Street, C. McCormick, K. Saksela, and M. Harris (2003)
J. Biol. Chem. 278, 17775-17784
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Activation of Human Monoamine Oxidase B Gene Expression by a Protein Kinase C MAPK Signal Transduction Pathway Involves c-Jun and Egr-1.

W. K. Wong, X.-M. Ou, K. Chen, and J. C. Shih (2002)
J. Biol. Chem. 277, 22222-22230
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Identification of Novel Point Mutations in ERK2 That Selectively Disrupt Binding to MEK1.

F. L. Robinson, A. W. Whitehurst, M. Raman, and M. H. Cobb (2002)
J. Biol. Chem. 277, 14844-14852
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A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells.

Z.-z. Su, I. V. Lebedeva, R. V. Gopalkrishnan, N. I. Goldstein, C. A. Stein, J. C. Reed, P. Dent, and P. B. Fisher (2001)
PNAS 98, 10332-10337
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PEA3 sites within the progression elevated gene-3 (PEG-3) promoter and mitogen-activated protein kinase contribute to differential PEG-3 expression in Ha-ras and v-raf oncogene transformed rat embryo cells.

Z. Su, Y. Shi, R. Friedman, L. Qiao, R. McKinstry, D. Hinman, P. Dent, and P. B. Fisher (2001)
Nucleic Acids Res. 29, 1661-1671
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Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions.

G. Pearson, F. Robinson, T. Beers Gibson, B.-e Xu, M. Karandikar, K. Berman, and M. H. Cobb (2001)
Endocr. Rev. 22, 153-183
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Pharmacologic Interruption of the Mitogen-activated Extracellular-regulated Kinase/Mitogen-activated Protein Kinase Signal Transduction Pathway: Potential Role in PromotingCytotoxic Drug Action.

P. Dent and S. Grant (2001)
Clin. Cancer Res. 7, 775-783
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Molecular mechanisms of ATP and insulin synergistic stimulation of coronary artery smooth muscle growth.

Y. M. Agazie, J. C. Bagot, E. Trickey, S. P. Halenda, and P. A. Wilden (2001)
Am J Physiol Heart Circ Physiol 280, H795-H801
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Raf-induced Transformation Requires an Interleukin 1 Autocrine Loop.

T. Vale, T. T. Ngo, M. A. White, and P. E. Lipsky (2001)
Cancer Res. 61, 602-607
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Small GTP-Binding Proteins.

Y. Takai, T. Sasaki, and T. Matozaki (2001)
Physiol Rev 81, 153-208
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Requirements of Multiple Domains of SLI-1, a Caenorhabditis elegans Homologue of c-Cbl, and an Inhibitory Tyrosine in LET-23 in Regulating Vulval Differentiation.

C. H. Yoon, C. Chang, N. A. Hopper, G. M. Lesa, and P. W. Sternberg (2000)
Mol. Biol. Cell 11, 4019-4031
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The Raf-1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments.

P. JANOSCH, A. KIESER, M. EULITZ, J. LOVRIC, G. SAUER, M. REICHERT, F. GOUNARI, D. BÜSCHER, M. BACCARINI, H. MISCHAK, et al. (2000)
FASEB J 14, 2008-2021
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Growth Factor-Independent Proliferation of Erythroid Cells Infected with Friend Spleen Focus-Forming Virus Is Protein Kinase C Dependent but Does Not Require Ras-GTP.

K. W. Muszynski, D. Thompson, C. Hanson, R. Lyons, A. Spadaccini, and S. K. Ruscetti (2000)
J. Virol. 74, 8444-8451
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Persistent Activation of ERK Contributes to Glutamate-induced Oxidative Toxicity in a Neuronal Cell Line and Primary Cortical Neuron Cultures.

M. Stanciu, Y. Wang, R. Kentor, N. Burke, S. Watkins, G. Kress, I. Reynolds, E. Klann, M. R. Angiolieri, J. W. Johnson, et al. (2000)
J. Biol. Chem. 275, 12200-12206
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Prolonged Activation of the Mitogen-activated Protein Kinase Pathway Is Required for Macrophage-like Differentiation of a Human Myeloid Leukemic Cell Line.

X. Hu, L. C. Moscinski, N. I. Valkov, A. B. Fisher, B. J. Hill, and K. S. Zuckerman (2000)
Cell Growth Differ. 11, 191-200
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EGF stimulates gastrin promoter through activation of Sp1 kinase activity.

S. Chupreta, M. Du, A. Todisco, and J. L. Merchant (2000)
Am J Physiol Cell Physiol 278, C697-C708
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IFN-{alpha}2b Reduces IL-2 Production and IL-2 Receptor Function in Primary CD4+ T Cells.

D. Zella, F. Romerio, S. Curreli, P. Secchiero, C. Cicala, D. Zagury, and R. C. Gallo (2000)
J. Immunol. 164, 2296-2302
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Parathyroid Hormone Stimulates Extracellular Signal-Regulated Kinase (ERK) Activity Through Two Independent Signal Transduction Pathways: Roleof ERK in Sodium-Phosphate Cotransport.

E. D. LEDERER, S. S. SOHI, and K. R. MCLEISH (2000)
J. Am. Soc. Nephrol. 11, 222-231
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Adenosine A2A Receptor mRNA Regulation by Nerve Growth Factor Is TrkA-, Src-, and Ras-dependent via Extracellular Regulated Kinase and Stress-activated Protein Kinase/c-Jun NH2-terminal Kinase.

R. L. Malek, Z. Nie, V. Ramkumar, and N. H. Lee (1999)
J. Biol. Chem. 274, 35499-35504
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Transcriptional Regulation of Fas Gene Expression by GA-binding Protein and AP-1 in T Cell Antigen Receptor{middle dot}CD3 Complex-stimulated T Cells.

X. R. Li, A. S.-F. Chong, J. Wu, K. A. Roebuck, A. Kumar, J. E. Parrillo, U. R. Rapp, R. P. Kimberly, J. W. Williams, and X. Xu (1999)
J. Biol. Chem. 274, 35203-35210
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Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metals.

W. Wu, L. M. Graves, I. Jaspers, R. B. Devlin, W. Reed, and J. M. Samet (1999)
Am J Physiol Lung Cell Mol Physiol 277, L924-L931
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Activation of Raf-1 during Experimental Gastric Ulcer Healing Is Ras-Mediated and Protein Kinase C-Independent.

R. Pai, M. K. Jones, M. Tomikawa, and A. S. Tarnawski (1999)
Am. J. Pathol. 155, 1759-1766
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Morphological Transformation Induced by Activation of the Mitogen-activated Protein Kinase Pathway Requires Suppression of the T-type Ca2+ Channel.

M. W. Strobeck, M. Okuda, H. Yamaguchi, A. Schwartz, and K. Fukasawa (1999)
J. Biol. Chem. 274, 15694-15700
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The Ankyrin Repeat-containing Adaptor Protein Tvl-1 Is a Novel Substrate and Regulator of Raf-1.

J.-H. Lin, A. Makris, C. McMahon, S. E. Bear, C. Patriotis, V. R. Prasad, R. Brent, E. A. Golemis, and P. N. Tsichlis (1999)
J. Biol. Chem. 274, 14706-14715
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Nerve Growth Factor-stimulated B-Raf Catalytic Activity Is Refractory to Inhibition by cAMP-dependent Protein Kinase.

M. C. MacNicol and A. M. MacNicol (1999)
J. Biol. Chem. 274, 13193-13197
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Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers.

H. J. Schaeffer and M. J. Weber (1999)
Mol. Cell. Biol. 19, 2435-2444
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Complementation of Defective Colony-Stimulating Factor 1 Receptor Signaling and Mitogenesis by Raf and v-Src.

N. Aziz, H. Cherwinski, and M. McMahon (1999)
Mol. Cell. Biol. 19, 1101-1115
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Activated MEK Stimulates Expression of AP-1 Components Independently of Phosphatidylinositol 3-Kinase (PI3-Kinase) but Requires a PI3-Kinase Signal To Stimulate DNA Synthesis.

I. Treinies, H. F. Paterson, S. Hooper, R. Wilson, and C. J. Marshall (1999)
Mol. Cell. Biol. 19, 321-329
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The Repertoire of Fos and Jun Proteins Expressed during the G1 Phase of the Cell Cycle Is Determined by the Duration of Mitogen-Activated Protein Kinase Activation.

S. J. Cook, N. Aziz, and M. McMahon (1999)
Mol. Cell. Biol. 19, 330-341
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The Amiloride-sensitive Epithelial Sodium Channel alpha -Subunit Is Transcriptionally Down-regulated in Rat Parotid Cells by the Extracellular Signal-regulated Protein Kinase Pathway.

M. D. Zentner, H. H. Lin, X. Wen, K. J. Kim, and D. K. Ann (1998)
J. Biol. Chem. 273, 30770-30776
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Active MAP Kinase in Mitosis: Localization at Kinetochores and Association with the Motor Protein CENP-E.

M. Zecevic, A. D. Catling, S. T. Eblen, L. Renzi, J. C. Hittle, T. J. Yen, G. J. Gorbsky, and M. J. Weber (1998)
J. Cell Biol. 142, 1547-1558
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Regulation of Human Involucrin Promoter Activity by a Protein Kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 Signal Transduction Pathway.

T. Efimova, P. LaCelle, J. F. Welter, and R. L. Eckert (1998)
J. Biol. Chem. 273, 24387-24395
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Mitotic Raf-1 Is Stimulated Independently of Ras and Is Active in the Cytoplasm.

A. Ziogas, I. C. Lorenz, K. Moelling, and G. Radziwill (1998)
J. Biol. Chem. 273, 24108-24114
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14-3-3 Proteins Are Required for Maintenance of Raf-1 Phosphorylation and Kinase Activity.

J. A. Thorson, L. W. K. Yu, A. L. Hsu, N.-Y. Shih, P. R. Graves, J. W. Tanner, P. M. Allen, H. Piwnica-Worms, and A. S. Shaw (1998)
Mol. Cell. Biol. 18, 5229-5238
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Oncogenic src, raf, and ras Stimulate a Hypertrophic Pattern of Gene Expression and Increase Cell Size in Neonatal Rat Ventricular Myocytes.

S. J. Fuller, J. Gillespie-Brown, and P. H. Sugden (1998)
J. Biol. Chem. 273, 18146-18152
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Nitroxides Tempol and Tempo Induce Divergent Signal Transduction Pathways in MDA-MB 231 Breast Cancer Cells.

S. Suy, J. B. Mitchell, D. Ehleiter, A. Haimovitz-Friedman, and U. Kasid (1998)
J. Biol. Chem. 273, 17871-17878
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Molecular mechanisms of impaired stimulation of DNA synthesis in cultured hepatocytes of aged rats.

S. Kitano, T. W. Fawcett, Y. Yo, and G. S. Roth (1998)
Am J Physiol Cell Physiol 275, C146-C154
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Differential Roles of Extracellular Signal-regulated Kinase-1/2 and p38MAPK in Interleukin-1beta - and Tumor Necrosis Factor-alpha -induced Low Density Lipoprotein Receptor Expression in HepG2 Cells.

A. Kumar, A. Middleton, T. C. Chambers, and K. D. Mehta (1998)
J. Biol. Chem. 273, 15742-15748
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Opposing Effects of Jun Kinase and p38 Mitogen-Activated Protein Kinases on Cardiomyocyte Hypertrophy.

S. Nemoto, Z. Sheng, and A. Lin (1998)
Mol. Cell. Biol. 18, 3518-3526
 |  Abstract »  |  Full Text »

Involvement of Extracellular Signal-Regulated Kinase Module in HIV-Mediated CD4 Signals Controlling Activation of Nuclear Factor-{kappa}B and AP-1 Transcription Factors.

L. Briant, V. Robert-Hebmann, V. Sivan, A. Brunet, J. Pouyssegur, and C. Devaux (1998)
J. Immunol. 160, 1875-1885
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Both the Polycythemia- and Anemia-Inducing Strains of Friend Spleen Focus-Forming Virus Induce Constitutive Activation of the Raf-1/Mitogen-Activated Protein Kinase Signal Transduction Pathway.

K. W. Muszynski, T. Ohashi, C. Hanson, and S. K. Ruscetti (1998)
J. Virol. 72, 919-925
 |  Abstract »  |  Full Text »  |  PDF »

Feedback Regulation of Raf-1 and Mitogen-activated Protein Kinase (MAP) Kinase Kinases 1 and 2 by MAP Kinase Phosphatase-1 (MKP-1).

P. S. Shapiro and N. G. Ahn (1998)
J. Biol. Chem. 273, 1788-1793
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Integration of Mitogen-Activated Protein Kinase Kinase Activation in Vascular 5-Hydroxytryptamine2A Receptor Signal Transduction.

J. A. Florian and S. W. Watts (1998)
J. Pharmacol. Exp. Ther. 284, 346-355
 |  Abstract »  |  Full Text »

A Novel Regulatory Mechanism in the Mitogen-activated Protein (MAP) Kinase Cascade. ROLE OF NUCLEAR EXPORT SIGNAL OF MAP KINASE KINASE.

M. Fukuda, I. Gotoh, M. Adachi, Y. Gotoh, and E. Nishida (1997)
J. Biol. Chem. 272, 32642-32648
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Insulin and Epidermal Growth Factor Stimulate a Conformational Change in Rap1 and Dissociation of the CrkII-C3G Complex.

S. Okada and J. E. Pessin (1997)
J. Biol. Chem. 272, 28179-28182
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Cholecystokinin and EGF activate a MAPK cascade by different mechanisms in rat pancreatic acinar cells.

A. Dabrowski, G. E. Groblewski, C. Schafer, K.-L. Guan, and J. A. Williams (1997)
Am J Physiol Cell Physiol 273, C1472-C1479
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Activation of the Mitogen-Activated Protein Kinase Pathway Is Involved in and Sufficient for Megakaryocytic Differentiation of CMK Cells.

A. S. Melemed, J. W. Ryder, and T. A. Vik (1997)
Blood 90, 3462-3470
 |  Abstract »  |  Full Text »  |  PDF »

Identification of c-Jun NH2-terminal Protein Kinase (JNK)-activating Kinase 2 as an Activator of JNK but Not p38.

X. Lu, S. Nemoto, and A. Lin (1997)
J. Biol. Chem. 272, 24751-24754
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Insulin-Induced Mitogen-Activated Protein (MAP) Kinase Phosphatase-1 (MKP-1) Attenuates Insulin-Stimulated MAP Kinase Activity: A Mechanism for the Feedback Inhibition of Insulin Signaling.

A. B. Kusari, J. Byon, D. Bandyopadhyay, K. A. Kenner, and J. Kusari (1997)
Mol. Endocrinol. 11, 1532-1543
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Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways Are Not Sufficient for Insulin-Like Growth Factor I-Induced Mitogenesis and Tumorigenesis.

A. G. Scrimgeour, V. A. Blakesley, B. S. Stannard, and D. LeRoith (1997)
Endocrinology 138, 2552-2558
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Constitutively Active Mutant of the Mitogen-activated Protein Kinase Kinase MEK1 Induces Epithelial Dedifferentiation and Growth Inhibition in Madin-Darby Canine Kidney-C7 Cells.

H. Schramek, E. Feifel, E. Healy, and V. Pollack (1997)
J. Biol. Chem. 272, 11426-11433
 |  Abstract »  |  Full Text »  |  PDF »

Uncoupling of Membrane Ruffling and Pinocytosis during Ras Signal Transduction.

G. Li, C. D'Souza-Schorey, M. A. Barbieri, J. A. Cooper, and P. D. Stahl (1997)
J. Biol. Chem. 272, 10337-10340
 |  Abstract »  |  Full Text »  |  PDF »

Physical Association with Ras Enhances Activation of Membrane-bound Raf (RafCAAX).

C. Mineo, R. G.W. Anderson, and M. A. White (1997)
J. Biol. Chem. 272, 10345-10348
 |  Abstract »  |  Full Text »  |  PDF »

Sequential Modification of Serines 621and 624in the Raf-1 Carboxyl Terminus Produces Alterations in Its Electrophoretic Mobility.

A. F. Ferrier, M. Lee, W. B. Anderson, G. Benvenuto, D. K. Morrison, D. R. Lowy, and J. E. DeClue (1997)
J. Biol. Chem. 272, 2136-2142
 |  Abstract »  |  Full Text »  |  PDF »

Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway.

K. M. Pumiglia and S. J. Decker (1997)
PNAS 94, 448-452
 |  Abstract »  |  Full Text »  |  PDF »

The E5 gene product of rhesus papillomavirus is an activator of endogenous Ras and phosphatidylinositol-3'-kinase in NIH 3T3 cells.

J. Ghai, R. S. Ostrow, J. Tolar, R. C. McGlennen, T. D. Lemke, D. Tobolt, Z. Liu, and A. J. Faras (1996)
PNAS 93, 12879-12884
 |  Abstract »  |  Full Text »  |  PDF »

Cytoplasmic Localization of Mitogen-activated Protein Kinase Kinase Directed by Its NH2-terminal, Leucine-rich Short Amino Acid Sequence, Which Acts as a Nuclear Export Signal.

M. Fukuda, I. Gotoh, Y. Gotoh, and E. Nishida (1996)
J. Biol. Chem. 271, 20024-20028
 |  Abstract »  |  Full Text »  |  PDF »

A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation.

M. A. White, T. Vale, J. H. Camonis, E. Schaefer, and M. H. Wigler (1996)
J. Biol. Chem. 271, 16439-16442
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Growth Factor-induced Protein Synthesis by a Selective MEK Inhibitor in Aortic Smooth Muscle Cells.

M. J. Servant, E. Giasson, and S. Meloche (1996)
J. Biol. Chem. 271, 16047-16052
 |  Abstract »  |  Full Text »  |  PDF »

Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells..

A Kieser, T Seitz, H S Adler, P Coffer, E Kremmer, P Crespo, J S Gutkind, D W Henderson, J F Mushinski, W Kolch, et al. (1996)
Genes & Dev. 10, 1455-1466
 |  Abstract »  |  PDF »

Equilibrium and Kinetic Measurements Reveal Rapidly Reversible Binding of Ras to Raf.

C. Gorman, R. H. Skinner, J. V. Skelly, S. Neidle, and P. N. Lowe (1996)
J. Biol. Chem. 271, 6713-6719
 |  Abstract »  |  Full Text »  |  PDF »

The Seven-transmembrane-spanning Receptors for Endothelin and Thrombin Cause Proliferation of Airway Smooth Muscle Cells and Activation of the Extracellular Regulated Kinase and c-Jun NH(2)-terminal Kinase Groups of Mitogen-activated Protein Kinases.

P. S. Shapiro, J. N. Evans, R. J. Davis, and J. A. Posada (1996)
J. Biol. Chem. 271, 5750-5754
 |  Abstract »  |  Full Text »  |  PDF »

Selective Activation of MEK1 but Not MEK2 by A-Raf from Epidermal Growth Factor-stimulated Hela Cells.

X. Wu, S. J. Noh, G. Zhou, J. E. Dixon, and K.-L. Guan (1996)
J. Biol. Chem. 271, 3265-3271
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Interaction of ras p21 with RalGDS and Raf-1 by Cyclic AMP-dependent Protein Kinase.

A. Kikuchi and L. T. Williams (1996)
J. Biol. Chem. 271, 588-594
 |  Abstract »  |  Full Text »  |  PDF »

Mos is required for MAP kinase activation and is involved in microtubule organization during meiotic maturation in the mouse.

M. Verlhac, J. Kubiak, M Weber, G Geraud, W. Colledge, M. Evans, and B Maro (1996)
Development 122, 815-822
 |  Abstract »  |  PDF »

Hypoxia and Hypoxia/Reoxygenation Activate Raf-1, Mitogen-Activated Protein Kinase Kinase, Mitogen-Activated Protein Kinases, and S6 Kinase in Cultured Rat Cardiac Myocytes.

Y. Seko, K. Tobe, K. Ueki, T. Kadowaki, and Y. Yazaki (1996)
Circ. Res. 78, 82-90
 |  Abstract »  |  Full Text »

Isolation of MEK5 and Differential Expression of Alternatively Spliced Forms.

J. M. English, C. A. Vanderbilt, S. Xu, S. Marcus, and M. H. Cobb (1995)
J. Biol. Chem. 270, 28897-28902
 |  Abstract »  |  Full Text »  |  PDF »

Sodium Butyrate Inhibits Platelet-Derived Growth Factor–Induced Proliferation of Vascular Smooth Muscle Cells.

K. Ranganna, T. Joshi, and F. M. Yatsu (1995)
Arterioscler Thromb Vasc Biol 15, 2273-2283
 |  Abstract »  |  Full Text »

Constitutive Activation of Mitogen-activated Protein Kinase-activated Protein Kinase 2 by Mutation of Phosphorylation Sites and an A-helix Motif.

K. Engel, H. Schultz, F. Martin, A. Kotlyarov, K. Plath, M. Hahn, U. Heinemann, and M. Gaestel (1995)
J. Biol. Chem. 270, 27213-27221
 |  Abstract »  |  Full Text »  |  PDF »

Purification of a 12,020-Dalton Protein That Enhances the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase.

A. Scott, C. M. M. Haystead, and T. A. J. Haystead (1995)
J. Biol. Chem. 270, 24540-24547
 |  Abstract »  |  Full Text »  |  PDF »

The Mouse B-raf Gene Encodes Multiple Protein Isoforms with Tissue-specific Expression.

J. V. Barnier, C. Papin, A. Eychène, O. Lecoq, and G. Calothy (1995)
J. Biol. Chem. 270, 23381-23389
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin.

D. F. Lazar, R. J. Wiese, M. J. Brady, C. C. Mastick, S. B. Waters, K. Yamauchi, J. E. Pessin, P. Cuatrecasas, and A. R. Saltiel (1995)
J. Biol. Chem. 270, 20801-20807
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-activated Protein Kinase Activation Requires Two Signal Inputs from the Human Anaphylatoxin C5a Receptor.

A. M. Buhl, S. Osawa, and G. L. Johnson (1995)
J. Biol. Chem. 270, 19828-19832
 |  Abstract »  |  Full Text »  |  PDF »

Angiotensin II Partly Mediates Mechanical Stress–Induced Cardiac Hypertrophy.

T. Yamazaki, I. Komuro, S. Kudoh, Y. Zou, I. Shiojima, T. Mizuno, H. Takano, Y. Hiroi, K. Ueki, K. Tobe, et al. (1995)
Circ. Res. 77, 258-265
 |  Abstract »  |  Full Text »

Dissociation of Mitogen-activated Protein Kinase Activation from the Oxidative Burst in Differentiated HL-60 Cells and Human Neutrophils.

H. Yu, S. J. Suchard, R. Nairn, and R. Jove (1995)
J. Biol. Chem. 270, 15719-15724
 |  Abstract »  |  Full Text »  |  PDF »

How MAP Kinases Are Regulated.

M. H. Cobb and E. J. Goldsmith (1995)
J. Biol. Chem. 270, 14843-14846
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Functional Mapping of the N-terminal Regulatory Domain in the Human Raf-1 Protein Kinase.

Y.-H. Chow, K. Pumiglia, T. H. Jun, P. Dent, T. W. Sturgill, and R. Jove (1995)
J. Biol. Chem. 270, 14100-14106
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Protein Kinase Cascades by Osmotic Shock.

S. Matsuda, H. Kawasaki, T. Moriguchi, Y. Gotoh, and E. Nishida (1995)
J. Biol. Chem. 270, 12781-12786
 |  Abstract »  |  Full Text »  |  PDF »

Purification of a Ras-dependent Mitogen-activated Protein Kinase Kinase Kinase from Bovine Brain Cytosol and Its Identification as a Complex of B-Raf and 14-3-3 Proteins.

B. Yamamori, S. Kuroda, K. Shimizu, K. Fukui, T. Ohtsuka, and Y. Takai (1995)
J. Biol. Chem. 270, 11723-11726
 |  Abstract »  |  Full Text »  |  PDF »

Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation..

K Galaktionov, C Jessus, and D Beach (1995)
Genes & Dev. 9, 1046-1058
 |  Abstract »  |  PDF »

Glucose, Other Secretagogues, and Nerve Growth Factor Stimulate Mitogen-activated Protein Kinase in the Insulin-secreting beta-Cell Line, INS-1.

M. Frödin, N. Sekine, E. Roche, C. Filloux, M. Prentki, C. B. Wollheim, and E. Van Obberghen (1995)
J. Biol. Chem. 270, 7882-7889
 |  Abstract »  |  Full Text »  |  PDF »

Staurosporine Causes Epidermal Growth Factor to Induce Differentiation in PC12 Cells via Receptor Up-regulation.

S. Raffioni and S. Raffioni (1995)
J. Biol. Chem. 270, 7568-7572
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical Analysis of MEK Activation in NIH3T3 Fibroblasts.

C. W. M. Reuter, A. D. Catling, T. Jelinek, and M. J. Weber (1995)
J. Biol. Chem. 270, 7644-7655
 |  Abstract »  |  Full Text »  |  PDF »

MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events..

Y Wu, M Han, and K L Guan (1995)
Genes & Dev. 9, 742-755
 |  Abstract »  |  PDF »

Reduced Activation of RAF-1 and MAP Kinase by a Fibroblast Growth Factor Receptor Mutant Deficient in Stimulation of Phosphatidylinositol Hydrolysis.

J. Huang, M. Mohammadi, G. A. Rodrigues, and J. Schlessinger (1995)
J. Biol. Chem. 270, 5065-5072
 |  Abstract »  |  Full Text »  |  PDF »

The MEK Kinase Activity of the Catalytic Domain of RAF-1 Is Regulated Independently of Ras Binding in T Cells.

C. E. Whitehurst, H. Owaki, J. T. Bruder, U. R. Rapp, and T. D. Geppert (1995)
J. Biol. Chem. 270, 5594-5599
 |  Abstract »  |  Full Text »  |  PDF »

A Constitutive Effector Region on the C-terminal Side of Switch I of the Ras Protein.

J. Fujita-Yoshigaki, M. Shirouzu, Y. Ito, S. Hattori, S. Furuyama, S. Nishimura, and S. Yokoyama (1995)
J. Biol. Chem. 270, 4661-4667
 |  Abstract »  |  Full Text »  |  PDF »

Purification and Characterization of REKS from Xenopus Eggs.

S. Kuroda, K. Shimizu, B. Yamamori, S. Matsuda, K. Imazumi, K. Kaibuchi, and Y. Takai (1995)
J. Biol. Chem. 270, 2460-2465
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Mitogen-Activated Protein Kinase in Porcine Carotid Arteries.

L. P. Adam, M. T. Franklin, G. J. Raff, and D. R. Hathaway (1995)
Circ. Res. 76, 183-190
 |  Abstract »  |  Full Text »

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