Science 28 August 1992: Vol. 257. no. 5074, pp. 1264 - 1267 DOI: 10.1126/science.1325672

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Articles

Complement Component 5a Receptor Oligomerization and Homologous Receptor Down-regulation.

M.-J. Rabiet, E. Huet, and F. Boulay (2008)
J. Biol. Chem. 283, 31038-31046
 |  Abstract »  |  Full Text »  |  PDF »

Activated G{alpha}13 Impairs Cell Invasiveness through p190RhoGAP-Mediated Inhibition of RhoA Activity.

R. A. Bartolome, N. Wright, I. Molina-Ortiz, F. J. Sanchez-Luque, and J. Teixido (2008)
Cancer Res. 68, 8221-8230
 |  Abstract »  |  Full Text »  |  PDF »

Nucleus accumbens AGS3 expression drives ethanol seeking through G{beta}{gamma}.

M. S. Bowers, F. W. Hopf, J. K. Chou, A. M. Guillory, S.-J. Chang, P. H. Janak, A. Bonci, and I. Diamond (2008)
PNAS 105, 12533-12538
 |  Abstract »  |  Full Text »  |  PDF »

M3 Muscarinic Acetylcholine Receptor-Mediated Signaling Is Regulated by Distinct Mechanisms.

J. Luo, J. M. Busillo, and J. L. Benovic (2008)
Mol. Pharmacol. 74, 338-347
 |  Abstract »  |  Full Text »  |  PDF »

Rich Tapestry of G Protein-Coupled Receptor Signaling and Regulatory Mechanisms.

V. V. Gurevich and E. V. Gurevich (2008)
Mol. Pharmacol. 74, 312-316
 |  Abstract »  |  Full Text »  |  PDF »

EGF Transregulates Opioid Receptors through EGFR-mediated GRK2 Phosphorylation and Activation.

Y. Chen, H. Long, Z. Wu, X. Jiang, and L. Ma (2008)
Mol. Biol. Cell 19, 2973-2983
 |  Abstract »  |  Full Text »  |  PDF »

G{beta}{gamma} Dimers Released in Response to Thyrotropin Activate Phosphoinositide 3-Kinase and Regulate Gene Expression in Thyroid Cells.

M. A. Zaballos, B. Garcia, and P. Santisteban (2008)
Mol. Endocrinol. 22, 1183-1199
 |  Abstract »  |  Full Text »  |  PDF »

Cardiac-restricted Expression of the Carboxyl-terminal Fragment of GRK3 Uncovers Distinct Functions of GRK3 in Regulation of Cardiac Contractility and Growth: GRK3 CONTROLS CARDIAC {alpha}1-ADRENERGIC RECEPTOR RESPONSIVENESS.

L. E. Vinge, T. G. von Lueder, E. Aasum, E. Qvigstad, J. A. Gravning, O.-J. How, T. Edvardsen, R. Bjornerheim, M. S. Ahmed, B. W. Mikkelsen, et al. (2008)
J. Biol. Chem. 283, 10601-10610
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of G-Protein Coupled Receptor Kinase Interaction with the Neurokinin-1 Receptor Using Bioluminescence Resonance Energy Transfer.

R. Jorgensen, N. D. Holliday, J. L. Hansen, M. Vrecl, A. Heding, T. W. Schwartz, and C. E. Elling (2008)
Mol. Pharmacol. 73, 349-358
 |  Abstract »  |  Full Text »  |  PDF »

Membrane Translocation of P-Rex1 Is Mediated by G Protein beta{gamma} Subunits and Phosphoinositide 3-Kinase.

M. A. Barber, S. Donald, S. Thelen, K. E. Anderson, M. Thelen, and H. C. E. Welch (2007)
J. Biol. Chem. 282, 29967-29976
 |  Abstract »  |  Full Text »  |  PDF »

Substrate Specificities of G Protein-Coupled Receptor Kinase-2 and -3 at Cardiac Myocyte Receptors Provide Basis for Distinct Roles in Regulation of Myocardial Function.

L. E. Vinge, K. W. Andressen, T. Attramadal, G. O. Andersen, M. S. Ahmed, K. Peppel, W. J. Koch, N. J. Freedman, F. O. Levy, T. Skomedal, et al. (2007)
Mol. Pharmacol. 72, 582-591
 |  Abstract »  |  Full Text »  |  PDF »

Conditional Stimulation of Type V and VI Adenylyl Cyclases by G Protein beta{gamma} Subunits.

X. Gao, R. Sadana, C. W. Dessauer, and T. B. Patel (2007)
J. Biol. Chem. 282, 294-302
 |  Abstract »  |  Full Text »  |  PDF »

G Protein-coupled Receptor (GPCR) Kinase 2 Regulates Agonist-independent Gq/11 Signaling from the Mouse Cytomegalovirus GPCR M33.

J. D. Sherrill and W. E. Miller (2006)
J. Biol. Chem. 281, 39796-39805
 |  Abstract »  |  Full Text »  |  PDF »

Trafficking of G Protein-Coupled Receptors.

M. T. Drake, S. K. Shenoy, and R. J. Lefkowitz (2006)
Circ. Res. 99, 570-582
 |  Abstract »  |  Full Text »  |  PDF »

Activation of heterotrimeric G proteins by Smoothened.

N. A. Riobo, B. Saucy, C. DiLizio, and D. R. Manning (2006)
PNAS 103, 12607-12612
 |  Abstract »  |  Full Text »  |  PDF »

The Structure of G Protein-coupled Receptor Kinase (GRK)-6 Defines a Second Lineage of GRKs.

D. T. Lodowski, V. M. Tesmer, J. L. Benovic, and J. J. G. Tesmer (2006)
J. Biol. Chem. 281, 16785-16793
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of G Protein-Coupled Receptor Kinase (GRK) 3 and GRK2 in Down-Regulation of the {alpha}2B-Adrenoceptor.

A. N. Desai, S. Salim, K. M. Standifer, and D. C. Eikenburg (2006)
J. Pharmacol. Exp. Ther. 317, 1027-1035
 |  Abstract »  |  Full Text »  |  PDF »

beta-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the beta2 Adrenergic Receptor.

S. K. Shenoy, M. T. Drake, C. D. Nelson, D. A. Houtz, K. Xiao, S. Madabushi, E. Reiter, R. T. Premont, O. Lichtarge, and R. J. Lefkowitz (2006)
J. Biol. Chem. 281, 1261-1273
 |  Abstract »  |  Full Text »  |  PDF »

Implication of G{beta}{gamma} proteins and c-SRC tyrosine kinase in parathyroid hormone-induced signal transduction in rat enterocytes.

C. Gentili, R. Boland, and A. R. de Boland (2006)
J. Endocrinol. 188, 69-78
 |  Abstract »  |  Full Text »  |  PDF »

A Docking Site for G Protein {beta}{gamma} Subunits on the Parathyroid Hormone 1 Receptor Supports Signaling through Multiple Pathways.

M. J. Mahon, T. M. Bonacci, P. Divieti, and A. V. Smrcka (2006)
Mol. Endocrinol. 20, 136-146
 |  Abstract »  |  Full Text »  |  PDF »

Snapshot of Activated G Proteins at the Membrane: The G{alpha}q-GRK2-G{beta}{gamma} Complex.

V. M. Tesmer, T. Kawano, A. Shankaranarayanan, T. Kozasa, and J. J. G. Tesmer (2005)
Science 310, 1686-1690
 |  Abstract »  |  Full Text »  |  PDF »

Exposure to TARC alters {beta}2-adrenergic receptor signaling in human peripheral blood T lymphocytes.

I. H. Heijink, E. Vellenga, J. Oostendorp, J. G. R. de Monchy, D. S. Postma, and H. F. Kauffman (2005)
Am J Physiol Lung Cell Mol Physiol 289, L53-L59
 |  Abstract »  |  Full Text »  |  PDF »

Structure/Function Analysis of {alpha}2A-Adrenergic Receptor Interaction with G Protein-coupledReceptor Kinase 2.

C. S. Pao and J. L. Benovic (2005)
J. Biol. Chem. 280, 11052-11058
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of {beta}-adrenergic receptor trafficking in adult cardiocytes by MAP4 decoration of microtubules.

G. Cheng, F. Qiao, T. N. Gallien, D. Kuppuswamy, and G. Cooper IV (2005)
Am J Physiol Heart Circ Physiol 288, H1193-H1202
 |  Abstract »  |  Full Text »  |  PDF »

Different G protein-coupled receptor kinases govern G protein and {beta}-arrestin-mediated signaling of V2 vasopressin receptor.

X.-R. Ren, E. Reiter, S. Ahn, J. Kim, W. Chen, and R. J. Lefkowitz (2005)
PNAS 102, 1448-1453
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the C-terminal Proline-rich Motif of G Protein-coupled Receptor Kinases in Recognition of Activated Rhodopsin.

X. Gan, Z. Ma, N. Deng, J. Wang, J. Ding, and L. Li (2004)
J. Biol. Chem. 279, 49741-49746
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Interaction Partners and Substrates of the Cyclin A1-CDK2 Complex.

S. Diederichs, N. Baumer, P. Ji, S. K. Metzelder, G. E. Idos, T. Cauvet, W. Wang, M. Moller, S. Pierschalski, J. Gromoll, et al. (2004)
J. Biol. Chem. 279, 33727-33741
 |  Abstract »  |  Full Text »  |  PDF »

Clathrin-mediated Endocytosis of m3 Muscarinic Receptors: ROLES FOR G{beta}{gamma} AND TUBULIN.

J. S. Popova and M. M. Rasenick (2004)
J. Biol. Chem. 279, 30410-30418
 |  Abstract »  |  Full Text »  |  PDF »

Coordination of Membrane Excitability through a GIRK1 Signaling Complex in the Atria.

E. N. Nikolov and T. T. Ivanova-Nikolova (2004)
J. Biol. Chem. 279, 23630-23636
 |  Abstract »  |  Full Text »  |  PDF »

A Predicted Amphipathic Helix Mediates Plasma Membrane Localization of GRK5.

M. M. Thiyagarajan, R. P. Stracquatanio, A. N. Pronin, D. S. Evanko, J. L. Benovic, and P. B. Wedegaertner (2004)
J. Biol. Chem. 279, 17989-17995
 |  Abstract »  |  Full Text »  |  PDF »

G Protein-coupled Receptor Kinase 2 Regulator of G Protein Signaling Homology Domain Binds to Both Metabotropic Glutamate Receptor 1a and G{alpha}q to Attenuate Signaling.

G. K. Dhami, L. B. Dale, P. H. Anborgh, K. E. O'Connor-Halligan, R. Sterne-Marr, and S. S. G. Ferguson (2004)
J. Biol. Chem. 279, 16614-16620
 |  Abstract »  |  Full Text »  |  PDF »

G Protein-coupled Receptor Kinase Interaction with Hsp90 Mediates Kinase Maturation.

J. Luo and J. L. Benovic (2003)
J. Biol. Chem. 278, 50908-50914
 |  Abstract »  |  Full Text »  |  PDF »

Insights into G Protein Structure, Function, and Regulation.

T. M. Cabrera-Vera, J. Vanhauwe, T. O. Thomas, M. Medkova, A. Preininger, M. R. Mazzoni, and H. E. Hamm (2003)
Endocr. Rev. 24, 765-781
 |  Abstract »  |  Full Text »  |  PDF »

Unchanged G-protein-coupled receptor kinase activity in the aging human heart.

K. Leineweber, S. Klapproth, A. Beilfuss, R.-E. Silber, G. Heusch, T. Philipp, and O.-E. Brodde (2003)
J. Am. Coll. Cardiol. 42, 1487-1492
 |  Abstract »  |  Full Text »  |  PDF »

Independent {beta}-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

H. Wei, S. Ahn, S. K. Shenoy, S. S. Karnik, L. Hunyady, L. M. Luttrell, and R. J. Lefkowitz (2003)
PNAS 100, 10782-10787
 |  Abstract »  |  Full Text »  |  PDF »

G{beta}{gamma} Mediates the Interplay between Tubulin Dimers and Microtubules in the Modulation of Gq Signaling.

J. S. Popova and M. M. Rasenick (2003)
J. Biol. Chem. 278, 34299-34308
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Intramolecular Interactions in the Regulation of G Protein-Coupled Receptor Kinase 2.

S. Sarnago, R. Roca, A. De Blasi, A. Valencia, F. Mayor Jr., and C. Murga (2003)
Mol. Pharmacol. 64, 629-639
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of G Protein-Coupled Receptors: GPCR Kinases in Heart Disease.

J. A. Hata and W. J. Koch (2003)
Mol. Interv. 3, 264-272
 |  Abstract »  |  Full Text »  |  PDF »

Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and G{beta}{gamma}.

D. T. Lodowski, J. A. Pitcher, W. D. Capel, R. J. Lefkowitz, and J. J. G. Tesmer (2003)
Science 300, 1256-1262
 |  Abstract »  |  Full Text »  |  PDF »

The Amino-terminal Domain of G-protein-coupled Receptor Kinase 2 Is a Regulatory Gbeta gamma Binding Site.

T. Eichmann, K. Lorenz, M. Hoffmann, J. Brockmann, C. Krasel, M. J. Lohse, and U. Quitterer (2003)
J. Biol. Chem. 278, 8052-8057
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of G Protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization.

T. A. Kohout and R. J. Lefkowitz (2003)
Mol. Pharmacol. 63, 9-18
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The beta gamma Subunit of Heterotrimeric G Proteins Interacts with RACK1 and Two Other WD Repeat Proteins.

E. J. Dell, J. Connor, S. Chen, E. G. Stebbins, N. P. Skiba, D. Mochly-Rosen, and H. E. Hamm (2002)
J. Biol. Chem. 277, 49888-49895
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitylation of the Transducin beta gamma Subunit Complex. REGULATION BY PHOSDUCIN.

M. Obin, B. Y. Lee, G. Meinke, A. Bohm, R. H. Lee, R. Gaudet, J. A. Hopp, V. Y. Arshavsky, B. M. Willardson, and A. Taylor (2002)
J. Biol. Chem. 277, 44566-44575
 |  Abstract »  |  Full Text »  |  PDF »

Vascular-Targeted Overexpression of G Protein-Coupled Receptor Kinase-2 in Transgenic Mice Attenuates beta -Adrenergic Receptor Signaling and Increases Resting Blood Pressure.

A. D. Eckhart, T. Ozaki, H. Tevaearai, H. A. Rockman, and W. J. Koch (2002)
Mol. Pharmacol. 61, 749-758
 |  Abstract »  |  Full Text »  |  PDF »

G Protein-Coupled Receptor Kinases 3 and 6 Use Different Pathways to Desensitize the Endogenous M3 Muscarinic Acetylcholine Receptor in Human SH-SY5Y Cells.

J. M. Willets, R. A. J. Challiss, E. Kelly, and S. R. Nahorski (2001)
Mol. Pharmacol. 60, 321-330
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of Cellular Invasion by Activated G-Protein Subunits Galpha o, Galpha i1, Galpha i2, and Galpha i3 and Sequestration of Gbeta gamma.

S. Faivre, K. Regnauld, E. Bruyneel, Q.-D. Nguyen, M. Mareel, S. Emami, and C. Gespach (2001)
Mol. Pharmacol. 60, 363-372
 |  Abstract »  |  Full Text »  |  PDF »

Agonist-Dependent Delivery of M2 Muscarinic Acetylcholine Receptors to the Cell Surface after Pertussis Toxin Treatment.

A. G. Roseberry, M. Bünemann, J. Elavunkal, and M. M. Hosey (2001)
Mol. Pharmacol. 59, 1256-1268
 |  Abstract »  |  Full Text »

Chronic morphine induces the concomitant phosphorylation and altered association of multiple signaling proteins: A novel mechanism for modulating cell signaling.

S. Chakrabarti, M. Oppermann, and A. R. Gintzler (2001)
PNAS 98, 4209-4214
 |  Abstract »  |  Full Text »  |  PDF »

Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling.

S. S. G. Ferguson (2001)
Pharmacol. Rev. 53, 1-24
 |  Abstract »  |  Full Text »  |  PDF »

Localization and Signaling of Gbeta Subunit Ste4p Are Controlled by a-Factor Receptor and the a-Specific Protein Asg7p.

J. Kim, E. Bortz, H. Zhong, T. Leeuw, E. Leberer, A. K. Vershon, and J. P. Hirsch (2000)
Mol. Cell. Biol. 20, 8826-8835
 |  Abstract »  |  Full Text »

Physiological Induction of a {beta}-Adrenergic Receptor Kinase Inhibitor Transgene Preserves {beta}-Adrenergic Responsiveness in Pressure-Overload Cardiac Hypertrophy.

B. S. Manning, K. Shotwell, L. Mao, H. A. Rockman, and W. J. Koch (2000)
Circulation 102, 2751-2757
 |  Abstract »  |  Full Text »  |  PDF »

Heterologous desensitization of response mediated by selective PKC-dependent phosphorylation of Gi-1 and Gi-2.

K. S. Murthy, J. R. Grider, and G. M. Makhlouf (2000)
Am J Physiol Cell Physiol 279, C925-C934
 |  Abstract »  |  Full Text »  |  PDF »

G Protein {beta}{gamma} Complexes in Circumvallate Taste Cells Involved in Bitter Transduction.

P. Rossler, I. Boekhoff, E. Tareilus, S. Beck, H. Breer, and J. Freitag (2000)
Chem Senses 25, 413-421
 |  Abstract »  |  Full Text »  |  PDF »

Cpc2, a Fission Yeast Homologue of Mammalian RACK1 Protein, Interacts with Ran1 (Pat1) Kinase To Regulate Cell Cycle Progression and Meiotic Development.

M. McLeod, B. Shor, A. Caporaso, W. Wang, H. Chen, and L. Hu (2000)
Mol. Cell. Biol. 20, 4016-4027
 |  Abstract »  |  Full Text »

Muscarinic Receptor Activation Promotes the Membrane Association of Tubulin for the Regulation of Gq-Mediated Phospholipase Cbeta 1 Signaling.

J. S. Popova and M. M. Rasenick (2000)
J. Neurosci. 20, 2774-2782
 |  Abstract »  |  Full Text »  |  PDF »

Mutational Analysis of Gbeta gamma and Phospholipid Interaction with G Protein-coupled Receptor Kinase 2.

C. V. Carman, L. S. Barak, C. Chen, L.-Y. Liu-Chen, J. J. Onorato, S. P. Kennedy, M. G. Caron, and J. L. Benovic (2000)
J. Biol. Chem. 275, 10443-10452
 |  Abstract »  |  Full Text »  |  PDF »

Interaction between the Conserved Region in the C-terminal Domain of GRK2 and Rhodopsin Is Necessary for GRK2 to Catalyze Receptor Phosphorylation.

X.-q. Gan, J.-y. Wang, Q.-h. Yang, Z. Li, F. Liu, G. Pei, and L. Li (2000)
J. Biol. Chem. 275, 8469-8474
 |  Abstract »  |  Full Text »  |  PDF »

Hybrid Transgenic Mice Reveal In Vivo Specificity of G Protein-Coupled Receptor Kinases in the Heart.

A. D. Eckhart, S. J. Duncan, R. B. Penn, J. L. Benovic, R. J. Lefkowitz, and W. J. Koch (2000)
Circ. Res. 86, 43-50
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of the Cardiac {beta}2-Adrenergic Receptor and Expression of a {beta}-Adrenergic Receptor Kinase-1 ({beta}ARK1) Inhibitor Both Increase Myocardial Contractility but Have Differential Effects on Susceptibility to Ischemic Injury.

H. R. Cross, C. Steenbergen, R. J. Lefkowitz, W. J. Koch, and E. Murphy (1999)
Circ. Res. 85, 1077-1084
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta 1-adrenergic receptor.

Y. Tang, L. A. Hu, W. E. Miller, N. Ringstad, R. A. Hall, J. A. Pitcher, P. DeCamilli, and R. J. Lefkowitz (1999)
PNAS 96, 12559-12564
 |  Abstract »  |  Full Text »  |  PDF »

The GRK4 Subfamily of G Protein-coupled Receptor Kinases. ALTERNATIVE SPLICING, GENE ORGANIZATION, AND SEQUENCE CONSERVATION.

R. T. Premont, A. D. Macrae, S. A. J. R. Aparicio, H. E. Kendall, J. E. Welch, and R. J. Lefkowitz (1999)
J. Biol. Chem. 274, 29381-29389
 |  Abstract »  |  Full Text »  |  PDF »

Coordinated Movement of RACK1 with Activated beta IIPKC.

D. Ron, Z. Jiang, L. Yao, A. Vagts, I. Diamond, and A. Gordon (1999)
J. Biol. Chem. 274, 27039-27046
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of beta -Adrenoceptor Signaling in Cardiac Function and Disease.

N. Dzimiri (1999)
Pharmacol. Rev. 51, 465-502
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Inhibition of Elevated Myocardial {beta}-Adrenergic Receptor Kinase Activity in Hybrid Transgenic Mice Restores Normal {beta}-Adrenergic Signaling and Function.

S. A. Akhter, A. D. Eckhart, H. A. Rockman, K. Shotwell, R. J. Lefkowitz, and W. J. Koch (1999)
Circulation 100, 648-653
 |  Abstract »  |  Full Text »  |  PDF »

Trafficking of Proteinase-activated Receptor-2 and beta -Arrestin-1 Tagged with Green Fluorescent Protein. beta -ARRESTIN-DEPENDENT ENDOCYTOSIS OF A PROTEINASE RECEPTOR.

O. Dery, M. S. Thoma, H. Wong, E. F. Grady, and N. W. Bunnett (1999)
J. Biol. Chem. 274, 18524-18535
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the G Protein-activating Domain of the Natriuretic Peptide Clearance Receptor (NPR-C).

K. S. Murthy and G. M. Makhlouf (1999)
J. Biol. Chem. 274, 17587-17592
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of C3a Activity: Internalization of the Human C3a Receptor and its Inhibition by C5a.

B. Settmacher, D. Bock, H. Saad, S. Gartner, C. Rheinheimer, J. Kohl, W. Bautsch, and A. Klos (1999)
J. Immunol. 162, 7409-7416
 |  Abstract »  |  Full Text »  |  PDF »

Ribozyme Approach Identifies a Functional Association between the G Protein beta 1gamma 7 Subunits in the beta -Adrenergic Receptor Signaling Pathway.

Q. Wang, B. K. Mullah, and J. D. Robishaw (1999)
J. Biol. Chem. 274, 17365-17371
 |  Abstract »  |  Full Text »  |  PDF »

Substance P-induced Trafficking of beta -Arrestins. THE ROLE OF beta -ARRESTINS IN ENDOCYTOSIS OF THE NEUROKININ-1 RECEPTOR.

K. McConalogue, O. Dery, M. Lovett, H. Wong, J. H. Walsh, E. F. Grady, and N. W. Bunnett (1999)
J. Biol. Chem. 274, 16257-16268
 |  Abstract »  |  Full Text »  |  PDF »

Role of Isoprenoid Lipids on the Heterotrimeric G Protein gamma  Subunit in Determining Effector Activation.

C.-S. Myung, H. Yasuda, W. W. Liu, T. K. Harden, and J. C. Garrison (1999)
J. Biol. Chem. 274, 16595-16603
 |  Abstract »  |  Full Text »  |  PDF »

Molecular beta -adrenergic signaling abnormalities in failing rabbit hearts after infarction.

J. P. Maurice, A. S. Shah, A. P. Kypson, J. A. Hata, D. C. White, D. D. Glower, and W. J. Koch (1999)
Am J Physiol Heart Circ Physiol 276, H1853-H1860
 |  Abstract »  |  Full Text »  |  PDF »

The RACK1 Signaling Scaffold Protein Selectively Interacts with the cAMP-specific Phosphodiesterase PDE4D5 Isoform.

S. J. Yarwood, M. R. Steele, G. Scotland, M. D. Houslay, and G. B. Bolger (1999)
J. Biol. Chem. 274, 14909-14917
 |  Abstract »  |  Full Text »  |  PDF »

G-protein coupled receptor kinases as modulators of G-protein signalling.

M. Bunemann and M M. Hosey (1999)
J. Physiol. 517, 5-23
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases.

F. Dicker, U. Quitterer, R. Winstel, K. Honold, and M. J. Lohse (1999)
PNAS 96, 5476-5481
 |  Abstract »  |  Full Text »  |  PDF »

Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis.

G. Iaccarino, L. A. Smithwick, R. J. Lefkowitz, and W. J. Koch (1999)
PNAS 96, 3945-3950
 |  Abstract »  |  Full Text »  |  PDF »

Differential Effects of CC Chemokines on CC Chemokine Receptor 5 (CCR5) Phosphorylation and Identification of Phosphorylation Sites on the CCR5 Carboxyl Terminus.

M. Oppermann, M. Mack, A. E. I. Proudfoot, and H. Olbrich (1999)
J. Biol. Chem. 274, 8875-8885
 |  Abstract »  |  Full Text »  |  PDF »

Real-time Visualization of the Cellular Redistribution of G Protein-coupled Receptor Kinase 2 and beta -Arrestin 2 during Homologous Desensitization of the Substance P Receptor.

L. S. Barak, K. Warabi, X. Feng, M. G. Caron, and M. M. Kwatra (1999)
J. Biol. Chem. 274, 7565-7569
 |  Abstract »  |  Full Text »  |  PDF »

RGS16 Attenuates Galpha q-dependent p38 Mitogen-activated Protein Kinase Activation by Platelet-activating Factor.

Y. Zhang, S. Y. Neo, J. Han, L. P. Yaw, and S.-C. Lin (1999)
J. Biol. Chem. 274, 2851-2857
 |  Abstract »  |  Full Text »  |  PDF »

Isoprenaline can activate the acetylcholine-induced K+ current in canine atrial myocytes via Gs-derived {beta}{gamma} subunits.

S. Sorota, I. Rybina, A. Yamamoto, and X.-Y. Du (1999)
J. Physiol. 514, 413-423
 |  Abstract »  |  Full Text »  |  PDF »

Receptor Selectivity of the Cloned Opossum G Protein-Coupled Receptor Kinase 2 (GRK2) in Intact Opossum Kidney Cells: Role in Desensitization of Endogenous {alpha}2C-Adrenergic but Not Serotonin 1B Receptors.

P. M. C. Lembo, M. H. Ghahremani, and P. R. Albert (1999)
Mol. Endocrinol. 13, 138-147
 |  Abstract »  |  Full Text »

Angiotensin II Receptor Coupling to Phospholipase D Is Mediated by the beta gamma Subunits of Heterotrimeric G Proteins in Vascular Smooth Muscle Cells.

M. Ushio-Fukai, R. W. Alexander, M. Akers, P. R. Lyons, B. Lassègue, and K. K. Griendling (1999)
Mol. Pharmacol. 55, 142-149
 |  Abstract »  |  Full Text »

Mapping of a Yeast G Protein ß{gamma} Signaling Interaction.

S. J. Dowell, A. L. Bishop, S. L. Dyos, A. J. Brown, and M. S. Whiteway (1998)
Genetics 150, 1407-1417
 |  Abstract »  |  Full Text »

beta 2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.

R. T. Premont, A. Claing, N. Vitale, J. L. R. Freeman, J. A. Pitcher, W. A. Patton, J. Moss, M. Vaughan, and R. J. Lefkowitz (1998)
PNAS 95, 14082-14087
 |  Abstract »  |  Full Text »  |  PDF »

Structure-Function Analysis of G Protein-coupled Receptor Kinase-5. ROLE OF THE CARBOXYL TERMINUS IN KINASE REGULATION.

A. N. Pronin, C. V. Carman, and J. L. Benovic (1998)
J. Biol. Chem. 273, 31510-31518
 |  Abstract »  |  Full Text »  |  PDF »

Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs.

G. Iaccarino, H. A. Rockman, K. F. Shotwell, E. D. Tomhave, and W. J. Koch (1998)
Am J Physiol Heart Circ Physiol 275, H1298-H1306
 |  Abstract »  |  Full Text »  |  PDF »

Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbeta gamma complex underlies activation of the yeast pheromone response pathway.

P. M. Pryciak and F. A. Huntress (1998)
Genes & Dev. 12, 2684-2697
 |  Abstract »  |  Full Text »

Phosphorylation of the G Protein gamma 12 Subunit Regulates Effector Specificity.

H. Yasuda, M. A. Lindorfer, C.-S. Myung, and J. C. Garrison (1998)
J. Biol. Chem. 273, 21958-21965
 |  Abstract »  |  Full Text »  |  PDF »

Binding and Phosphorylation of Tubulin by G Protein-coupled Receptor Kinases.

C. V. Carman, T. Som, C. M. Kim, and J. L. Benovic (1998)
J. Biol. Chem. 273, 20308-20316
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of Acute Desensitization of the beta 2AR-Adenylyl Cyclase Pathway in Human Airway Smooth Muscle.

R. B. Penn, R. A. Panettieri Jr., and J. L. Benovic (1998)
Am. J. Respir. Cell Mol. Biol. 19, 338-348
 |  Abstract »  |  Full Text »

G Protein Signaling and Vein Graft Intimal Hyperplasia : Reduction of Intimal Hyperplasia in Vein Grafts by a Gß{gamma} Inhibitor Suggests a Major Role of G Protein Signaling in Lesion Development.

M. G. Davies, T. T. T. Huynh, G. J. Fulton, R. J. Lefkowitz, E. Svendsen, P.-O. Hagen, and W. J. Koch (1998)
Arterioscler Thromb Vasc Biol 18, 1275-1280
 |  Abstract »  |  Full Text »  |  PDF »

Desensitization of the Neurokinin-1 Receptor (NK1-R) in Neurons: Effects of Substance P on the Distribution of NK1-R, Galpha q/11, G-Protein Receptor Kinase-2/3, and beta -Arrestin-1/2.

K. McConalogue, C. U. Corvera, P. D. Gamp, E. F. Grady, and N. W. Bunnett (1998)
Mol. Biol. Cell 9, 2305-2324
 |  Abstract »  |  Full Text »

Control of Myocardial Contractile Function by the Level of beta -Adrenergic Receptor Kinase 1 in Gene-targeted Mice.

H. A. Rockman, D.-J. Choi, S. A. Akhter, M. Jaber, B. Giros, R. J. Lefkowitz, M. G. Caron, and W. J. Koch (1998)
J. Biol. Chem. 273, 18180-18184
 |  Abstract »  |  Full Text »  |  PDF »

Sites for Galpha Binding on the G Protein beta  Subunit Overlap with Sites for Regulation of Phospholipase Cbeta and Adenylyl Cyclase.

Y. Li, P. M. Sternweis, S. Charnecki, T. F. Smith, A. G. Gilman, E. J. Neer, and T. Kozasa (1998)
J. Biol. Chem. 273, 16265-16272
 |  Abstract »  |  Full Text »  |  PDF »

Expression of a beta -adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.

H. A. Rockman, K. R. Chien, D.-J. Choi, G. Iaccarino, J. J. Hunter, J. Ross Jr., R. J. Lefkowitz, and W. J. Koch (1998)
PNAS 95, 7000-7005
 |  Abstract »  |  Full Text »  |  PDF »

RACK1, a Receptor for Activated C Kinase and a Homolog of the beta  Subunit of G Proteins, Inhibits Activity of Src Tyrosine Kinases and Growth of NIH 3T3 Cells.

B. Y. Chang, K. B. Conroy, E. M. Machleder, and C. A. Cartwright (1998)
Mol. Cell. Biol. 18, 3245-3256
 |  Abstract »  |  Full Text »

Molecular Basis for Interactions of G Protein Subunits with Effectors.

C. E. Ford, N. P. Skiba, H. Bae, Y. Daaka, E. Reuveny, L. R. Shekter, R. Rosal, G. Weng, C. Yang, R. Iyengar, et al. (1998)
Science 280, 1271-1274
 |  Abstract »  |  Full Text »

A Mitogen-activated Protein Kinase Pathway Is Required for µ-Opioid Receptor Desensitization.

R. D. Polakiewicz, S. M. Schieferl, L. F. Dorner, V. Kansra, and M. J. Comb (1998)
J. Biol. Chem. 273, 12402-12406
 |  Abstract »  |  Full Text »  |  PDF »

Receptor Docking Sites for G-protein beta gamma Subunits. IMPLICATIONS FOR SIGNAL REGULATION.

G. Wu, J. L. Benovic, J. D. Hildebrandt, and S. M. Lanier (1998)
J. Biol. Chem. 273, 7197-7200
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Rhodopsin Kinase in Octopus Photoreceptor Possesses a Pleckstrin Homology Domain and Is Activated by G Protein beta gamma -Subunits.

S. Kikkawa, N. Yoshida, M. Nakagawa, T. Iwasa, and M. Tsuda (1998)
J. Biol. Chem. 273, 7441-7447
 |  Abstract »  |  Full Text »  |  PDF »

Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2.

A. M. Aragay, M. Mellado, J. M. R. Frade, A. M. Martin, M. C. Jimenez-Sainz, C. Martinez-A, and F. Mayor Jr. (1998)
PNAS 95, 2985-2990
 |  Abstract »  |  Full Text »  |  PDF »

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