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Science 21 August 1992:
Vol. 257. no. 5073, pp. 1089 - 1095
DOI: 10.1126/science.257.5073.1089
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Articles

Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor

Dorre A. Grueneberg 1, Sridaran Natesan 1, Cyrille Alexandre 1, and Michael Z. Gilman 1

1 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724

Cells with distinct developmental histories can respond differentially to identical signals, suggesting that signals are interpreted in a fashion that reflects a cell's identity. How this might occur is suggested by the observation that proteins of the homeodomain family, including a newly identified human protein, enhance the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. Interaction with proteins of the serum response factor family may allow homeodomain proteins to specify the transcriptional response to inductive signals. Moreover, because the ability to enhance the binding of serum response factor to DNA resides within the homeodomain but is independent of homeodomain DNA-binding activity, this additional activity of the homeodomain may account for some of the specificity of action of homeodomain proteins in development.


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
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   Abstract »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
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   Abstract »    Full Text »
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   Abstract »    Full Text »    PDF »
Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins..
C P Chang, W F Shen, S Rozenfeld, H J Lawrence, C Largman, and M L Cleary (1995)
Genes & Dev. 9, 663-674
   Abstract »    PDF »
Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus..
D D Spyropoulos and M R Capecchi (1994)
Genes & Dev. 8, 1949-1961
   Abstract »    PDF »
Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis.
D. Edmondson, G. Lyons, J. Martin, and E. Olson (1994)
Development 120, 1251-1263
   Abstract »    PDF »
DNA bending and orientation-dependent function of YY1 in the c-fos promoter..
S Natesan and M Z Gilman (1993)
Genes & Dev. 7, 2497-2509
   Abstract »    PDF »
The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype.
I. Valarche, J. P. Tissier-Seta, M. R. Hirsch, S. Martinez, C. Goridis, and J. F. Brunet (1993)
Development 119, 881-896
   Abstract »    PDF »
Cooperative dimerization of paired class homeo domains on DNA..
D Wilson, G Sheng, T Lecuit, N Dostatni, and C Desplan (1993)
Genes & Dev. 7, 2120-2134
   Abstract »    PDF »
HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization.
S Wagner and M. Green (1993)
Science 262, 395-399
   Abstract »    PDF »
Cooperative interactions between the Caenorhabditis elegans homeoproteins UNC-86 and MEC-3.
D Xue, Y Tu, and M Chalfie (1993)
Science 261, 1324-1328
   Abstract »    PDF »
Coupling of cell identity to signal response in yeast: interaction between the alpha 1 and STE12 proteins..
Y O Yuan, I L Stroke, and S Fields (1993)
Genes & Dev. 7, 1584-1597
   Abstract »    PDF »
The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences..
S K Chan and R S Mann (1993)
Genes & Dev. 7, 796-811
   Abstract »    PDF »
A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage.
R. Breitbart, C. Liang, L. Smoot, D. Laheru, V Mahdavi, and B Nadal-Ginard (1993)
Development 118, 1095-1106
   Abstract »    PDF »
Induction of Smooth Muscle alpha -Actin in Vascular Smooth Muscle Cells by Arginine Vasopressin Is Mediated by c-Jun Amino-terminal Kinases and p38 Mitogen-activated Protein Kinase.
C. Garat, V. Van Putten, Z. A. Refaat, C. Dessev, S.-Y. Han, and R. A. Nemenoff (2000)
J. Biol. Chem. 275, 22537-22543
   Abstract »    Full Text »    PDF »
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J. A. Carson, R. A. Fillmore, R. J. Schwartz, and W. E. Zimmer (2000)
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   Abstract »    Full Text »    PDF »
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K. Kataoka, K. Yoshitomo-Nakagawa, S. Shioda, and M. Nishizawa (2001)
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   Abstract »    Full Text »    PDF »
Superactivation of Pax6-mediated Transactivation from Paired Domain-binding Sites by DNA-independent Recruitment of Different Homeodomain Proteins.
I. Mikkola, J.-A. Bruun, T. Holm, and T. Johansen (2001)
J. Biol. Chem. 276, 4109-4118
   Abstract »    Full Text »    PDF »
Muscle Specificity Encoded by Specific Serum Response Factor-binding Sites.
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   Abstract »    Full Text »    PDF »
The Identification of Prx1 Transcription Regulatory Domains Provides a Mechanism for Unequal Compensation by the Prx1 and Prx2 Loci.
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J. Biol. Chem. 276, 26829-26837
   Abstract »    Full Text »    PDF »
Binding of Serum Response Factor to CArG Box Sequences Is Necessary but Not Sufficient to Restrict Gene Expression to Arterial Smooth Muscle Cells.
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J. Biol. Chem. 276, 16418-16424
   Abstract »    Full Text »    PDF »
Transcriptional Activation of beta -Tropomyosin Mediated by Serum Response Factor and a Novel Barx Homologue, Barx1b, in Smooth Muscle Cells.
M. Nakamura, W. Nishida, S. Mori, K. Hiwada, K.'i. Hayashi, and K. Sobue (2001)
J. Biol. Chem. 276, 18313-18320
   Abstract »    Full Text »    PDF »
Differential Binding of an SRF/NK-2/MEF2 Transcription Factor Complex in Normal Versus Neoplastic Smooth Muscle Tissues.
C. J. Phiel, V. Gabbeta, L. M. Parsons, D. Rothblat, R. P. Harvey, and K. M. McHugh (2001)
J. Biol. Chem. 276, 34637-34650
   Abstract »    Full Text »    PDF »
Alx4 Binding to LEF-1 Regulates N-CAM Promoter Activity.
K. Boras and P. A. Hamel (2002)
J. Biol. Chem. 277, 1120-1127
   Abstract »    Full Text »    PDF »


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