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Science 21 August 1992:
Vol. 257. no. 5073, pp. 1055 - 1064
DOI: 10.1126/science.257.5073.1055
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Articles

Tuberculosis: Commentary on a Reemergent Killer

Barry R. Bloom 1 and Christopher J. L. Murray 2

1 Investigator at the Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY 10461
2 Assistant Professor of the Harvard School of Public Health at the Center for Population and Development Studies, Cambridge, MA 02138

Tuberculosis remains the leading cause of death in the world from a single infectious disease, although there is little knowledge of the mechanisms of its pathogenesis and protection from it. After a century of decline in the United States, tuberculosis is increasing, and strains resistant to multiple antibiotics have emerged. This excess of cases is attributable to changes in the social structure in cities, the human immunodeficiency virus epidemic, and a failure in certain major cities to improve public treatment programs. The economic costs of not adequately addressing the problem of tuberculosis in this country are estimated from an epidemiological model.


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Am. J. Respir. Crit. Care Med. 168, 1353-1357
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   Abstract »    Full Text »    PDF »
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J. Immunol. 169, 5181-5187
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Infect. Immun. 69, 7310-7317
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Influence of Mycobacterium bovis Bacillus Calmette Guerin on In Vitro Induction of CD1 Molecules in Human Adherent Mononuclear Cells.
A. Giuliani, S. P. Prete, G. Graziani, A. Aquino, A. Balduzzi, M. Sugita, M. B. Brenner, E. Iona, L. Fattorini, G. Orefici, et al. (2001)
Infect. Immun. 69, 7461-7470
   Abstract »    Full Text »    PDF »
Maternal Antibodies, Childhood Infections, and Autoimmune Diseases.
R. M. Zinkernagel (2001)
N. Engl. J. Med. 345, 1331-1335
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Identification of two Mycobacterium avium subspecies paratuberculosis gene products differentially recognised by sera from rabbits immunised with live mycobacteria but not heat-killed mycobacteria.
J. P. BANNANTINE and J. R. STABEL (2001)
J. Med. Microbiol. 50, 795-804
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Induction of Cell-Mediated Immunity against Mycobacterium tuberculosis Using DNA Vaccines Encoding Cytotoxic and Helper T-Cell Epitopes of the 38-Kilodalton Protein.
D. P. A. J. Fonseca, B. Benaissa-Trouw, M. van Engelen, C. A. Kraaijeveld, H. Snippe, and A. F. M. Verheul (2001)
Infect. Immun. 69, 4839-4845
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Capillary Electrophoresis-based Heteroduplex Analysis with a Universal Heteroduplex Generator for Detection of Point Mutations Associated with Rifampin Resistance in Tuberculosis.
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In Vitro Activity of a Novel Antimycobacterial Compound, N-Octanesulfonylacetamide, and Its Effects on Lipid and Mycolic Acid Synthesis.
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Infect. Immun. 69, 2714-2717
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J. Clin. Microbiol. 39, 1591-1594
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Intracellular pH regulation by Mycobacterium smegmatis and Mycobacterium bovis BCG.
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N Shetty, M Shemko, J Holton, and G M Scott (2000)
J. Clin. Pathol. 53, 924-928
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Increased Numbers of ESAT-6- and Purified Protein Derivative-Specific Gamma Interferon-Producing Cells in Subclinical and Active Tuberculosis Infection.
T. Ulrichs, P. Anding, S. Porcelli, S. H. E. Kaufmann, and M. E. Munk (2000)
Infect. Immun. 68, 6073-6076
   Abstract »    Full Text »    PDF »
Evaluation of Etest for Susceptibility Testing of Mycobacterium tuberculosis.
M. L. Joloba, S. Bajaksouzian, and M. R. Jacobs (2000)
J. Clin. Microbiol. 38, 3834-3836
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Mycobacterium tuberculosis Infection in Complement Receptor 3-Deficient Mice.
C. Hu, T. Mayadas-Norton, K. Tanaka, J. Chan, and P. Salgame (2000)
J. Immunol. 165, 2596-2602
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A Macrophage Invasion Mechanism for Mycobacteria Implicating the Extracellular Domain of Cd43.
C. Fratazzi, N. Manjunath, R. D. Arbeit, C. Carini, T. A. Gerken, B. Ardman, E. Remold-O'Donnell, and H. G. Remold (2000)
J. Exp. Med. 192, 183-192
   Abstract »    Full Text »    PDF »
Cloning and Expression of Immunoreactive Antigens from Mycobacterium tuberculosis.
R. L. Hong Lim, L. Kiang Tan, W. Fun Lau, M. Ching Ming, Chung, R. Dunn, H. Phon Too, and L. Chan (2000)
Clin. Vaccine Immunol. 7, 600-606
   Abstract »    Full Text »    PDF »
Tuberculosis DNA Vaccine Encoding Ag85A Is Immunogenic and Protective When Administered by Intramuscular Needle Injection but Not by Epidermal Gene Gun Bombardment.
A. Tanghe, O. Denis, B. Lambrecht, V. Motte, T. van den Berg, and K. Huygen (2000)
Infect. Immun. 68, 3854-3860
   Abstract »    Full Text »    PDF »
An Essential Two-Component Signal Transduction System in Mycobacterium tuberculosis.
T. C. Zahrt and V. Deretic (2000)
J. Bacteriol. 182, 3832-3838
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Genetic Antagonism and Hypermutability in Mycobacterium smegmatis.
P. Karunakaran and J. Davies (2000)
J. Bacteriol. 182, 3331-3335
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Characterization of a Mycobacterium smegmatis Mutant That Is Simultaneously Resistant to D-Cycloserine and Vancomycin.
M. Peteroy, A. Severin, F. Zhao, D. Rosner, U. Lopatin, H. Scherman, A. Belanger, B. Harvey, G. F. Hatfull, P. J. Brennan, et al. (2000)
Antimicrob. Agents Chemother. 44, 1701-1704
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Characterization of the Heparin-binding Site of the Mycobacterial Heparin-binding Hemagglutinin Adhesin.
K. Pethe, M. Aumercier, E. Fort, C. Gatot, C. Locht, and F. D. Menozzi (2000)
J. Biol. Chem. 275, 14273-14280
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Cloning of the Gene Encoding a 22-Kilodalton Cell Surface Antigen of Mycobacterium bovis BCG and Analysis of Its Potential for DNA Vaccination against Tuberculosis.
P. Lefevre, O. Denis, L. De Wit, A. Tanghe, P. Vandenbussche, J. Content, and K. Huygen (2000)
Infect. Immun. 68, 1040-1047
   Abstract »    Full Text »    PDF »
Imaging of Extrapulmonary Tuberculosis : (CME available in print version and on RSNA Link).
G. Engin, B. Acunas, G. Acunas, and M. Tunaci (2000)
RadioGraphics 20, 471-488
   Abstract »    Full Text »    PDF »
Disruption of the Genes Encoding Antigen 85A and Antigen 85B of Mycobacterium tuberculosis H37Rv: Effect on Growth in Culture and in Macrophages.
L. Y. Armitige, C. Jagannath, A. R. Wanger, and S. J. Norris (2000)
Infect. Immun. 68, 767-778
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Lipoglycans Are Putative Ligands for the Human Pulmonary Surfactant Protein A Attachment to Mycobacteria. CRITICAL ROLE OF THE LIPIDS FOR LECTIN-CARBOHYDRATE RECOGNITION.
S. Sidobre, J. Nigou, G. Puzo, and M. Riviere (2000)
J. Biol. Chem. 275, 2415-2422
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Action Mechanism of Antitubercular Isoniazid. ACTIVATION BY MYCOBACTERIUM TUBERCULOSIS KatG, ISOLATION, AND CHARACTERIZATION OF InhA INHIBITOR.
B. Lei, C.-J. Wei, and S.-C. Tu (2000)
J. Biol. Chem. 275, 2520-2526
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Activation of Human Neutrophils by Mycobacterium tuberculosis H37Ra Involves Phospholipase C{gamma}2, Shc Adapter Protein, and p38 Mitogen-Activated Protein Kinase.
N. Perskvist, L. Zheng, and O. Stendahl (2000)
J. Immunol. 164, 959-965
   Abstract »    Full Text »    PDF »
Functional Domains Present in the Mycobacterial Hemagglutinin, HBHA.
G. Delogu and M. J. Brennan (1999)
J. Bacteriol. 181, 7464-7469
   Abstract »    Full Text »
Sliding Motility in Mycobacteria.
A. Martínez, S. Torello, and R. Kolter (1999)
J. Bacteriol. 181, 7331-7338
   Abstract »    Full Text »


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