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Science 7 August 1992:
Vol. 257. no. 5071, pp. 813 - 815
DOI: 10.1126/science.1496402
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Articles
Science, Vol 257, Issue 5071, 813-815
Copyright © 1992 by American Association for the Advancement of Science
Activation of transcription factors by interferon-alpha in a cell-free system
M David
and
AC Larner
Division of Cytokine Biology, Center for Biologics Evaluation and Research, Bethesda, MD 20892.
The signal transduction mechanisms of interferons (IFNs) remain unclear partly because no effect of IFN has been reproducible in a cell-free system. IFN-alpha rapidly induces the transcription of a set of early response genes, and a multicomponent transcriptional activator, interferon stimulated gene factor 3 (ISGF3), is activated within minutes after binding of IFN-alpha to its receptor. A system was developed in which IFN-alpha activated ISGF3 in homogenates of HeLa cells. Subcellular fractionation revealed that incubation of a plasma membrane-enriched fraction with IFN-alpha was sufficient to activate the regulatory subcomponent of ISGF3.
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