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Science 31 July 1992:
Vol. 257. no. 5070, pp. 678 - 679
DOI: 10.1126/science.1496381
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Articles

Science, Vol 257, Issue 5070, 678-679
Copyright © 1992 by American Association for the Advancement of Science

articles

Specialized role for a murine class I-b MHC molecule in prokaryotic host defenses

RJ Kurlander, SM Shawar, ML Brown, and RR Rich

Department of Medicine, Duke Medical Center, Durham, NC 27710.

Although nonclassical (class I-b) gene products represent the majority of murine major histocompatibility complex (MHC) genes, the role of these relatively nonpolymorphic molecules remains uncertain. Recently, one such protein, H-2M3 (formerly designated Hmt), was shown to bind and specifically present N-formylated peptides to cytotoxic T lymphocytes. Because N-formylation is characteristic of prokaryotic proteins, this MHC molecule may be especially adapted for a role in the mammalian defense against bacterial attack. The current studies demonstrate that an MHC molecule, indistinguishable from H-2M3, presents antigens derived from the intracellular pathogen Listeria monocytogenes to Listeria-specific CD8+ cells.


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H2-M3 Restricted Presentation of a Listeria-derived Leader Peptide.
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