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Science 31 July 1992:
Vol. 257. no. 5070, pp. 652 - 655
DOI: 10.1126/science.1496377
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Articles

Science, Vol 257, Issue 5070, 652-655
Copyright © 1992 by American Association for the Advancement of Science

articles

The location of bound lipid in the lipovitellin complex

PA Timmins, B Poliks, and L Banaszak

Institut Laue-Langevin, Grenoble, France.

The location of the bound lipid in the soluble lipoprotein lipovitellin has been determined by neutron crystallographic techniques. With the use of the contrast variation method, whereby the crystals are soaked in different H2O-D2O mixtures, the lipid has been found to occupy a large cavity in the protein whose structure had previously been determined by x-ray crystallography. The lipid appears to be bound in the form of a bilayer with the major protein-lipid interactions being hydrophobic and with the lipid headgroups projecting into the bulk solvent and into a solvent-filled space in the cavity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Mechanism of Membrane Neutral Lipid Acquisition by the Microsomal Triglyceride Transfer Protein.
J. Read, T. A. Anderson, P. J. Ritchie, B. Vanloo, J. Amey, D. Levitt, M. Rosseneu, J. Scott, and C. C. Shoulders (2000)
J. Biol. Chem. 275, 30372-30377
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