Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 12 June 1992:
Vol. 256. no. 5063, pp. 1563 - 1566
DOI: 10.1126/science.1317969
Prev | Table of Contents | Next

Articles

Science, Vol 256, Issue 5063, 1563-1566
Copyright © 1992 by American Association for the Advancement of Science

articles

Calcium entry through kainate receptors and resulting potassium-channel blockade in Bergmann glial cells

T Muller, T Moller, T Berger, J Schnitzer, and H Kettenmann

Department of Neurobiology, University of Heidelberg, Germany.

Glutamate receptors, the most abundant excitatory transmitter receptors in the brain, are not restricted to neurons; they have also been detected on glial cells. Bergmann glial cells in mouse cerebellar slices revealed a kainate-type glutamate receptor with a sigmoid current-to-voltage relation, as demonstrated with the patch-clamp technique. Calcium was imaged with fura-2, and a kainate-induced increase in intracellular calcium concentration was observed, which was blocked by the non-N-methyl-D-aspartate (NMDA) glutamate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and by low concentrations of external calcium, indicating that there was an influx of calcium through the kainate receptor itself. The entry of calcium led to a marked reduction in the resting (passive) potassium conductance of the cell. Purkinje cells, which have glutamatergic synapses, are closely associated with Bergmann glial cells and therefore may provide a functionally important stimulus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
GABA uptake-dependent Ca2+ signaling in developing olfactory bulb astrocytes.
M. Doengi, D. Hirnet, P. Coulon, H.-C. Pape, J. W. Deitmer, and C. Lohr (2009)
PNAS 106, 17570-17575
   Abstract »    Full Text »    PDF »
GABAergic activities enhance macrophage inflammatory protein-1{alpha} release from microglia (brain macrophages) in postnatal mouse brain.
G. Cheung, O. Kann, S. Kohsaka, K. Faerber, and H. Kettenmann (2009)
J. Physiol. 587, 753-768
   Abstract »    Full Text »    PDF »
The {delta}2 'ionotropic' glutamate receptor functions as a non-ionotropic receptor to control cerebellar synaptic plasticity.
W. Kakegawa, K. Kohda, and M. Yuzaki (2007)
J. Physiol. 584, 89-96
   Abstract »    Full Text »    PDF »
NMDA Receptors in Glia.
A. Verkhratsky and F. Kirchhoff (2007)
Neuroscientist 13, 28-37
   Abstract »    PDF »
The Activation of Excitatory Glutamate Receptors Evokes a Long-Lasting Increase in the Release of GABA from Cerebellar Stellate Cells.
S. J. Liu and P. Lachamp (2006)
J. Neurosci. 26, 9332-9339
   Abstract »    Full Text »    PDF »
Brief bursts of parallel fiber activity trigger calcium signals in bergmann glia..
M. Beierlein and W. G. Regehr (2006)
J. Neurosci. 26, 6958-6967
   Abstract »    Full Text »    PDF »
NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes..
U. Lalo, Y. Pankratov, F. Kirchhoff, R. A. North, and A. Verkhratsky (2006)
J. Neurosci. 26, 2673-2683
   Abstract »    Full Text »    PDF »
Diversity of Functional Astroglial Properties in the Respiratory Network.
D. Grass, P. G. Pawlowski, J. Hirrlinger, N. Papadopoulos, D. W. Richter, F. Kirchhoff, and S. Hulsmann (2004)
J. Neurosci. 24, 1358-1365
   Abstract »    Full Text »    PDF »
Long-lasting modulation of synaptic input to Purkinje neurons by Bergmann glia stimulation in rat brain slices.
J. Brockhaus and J. W Deitmer (2002)
J. Physiol. 545, 581-593
   Abstract »    Full Text »    PDF »
Na+ Entry Through AMPA Receptors Results in Voltage-Gated K+ Channel Blockade in Cultured Rat Spinal Cord Motoneurons.
P. Van Damme, L. Van den Bosch, E. Van Houtte, J. Eggermont, G. Callewaert, and W. Robberecht (2002)
J Neurophysiol 88, 965-972
   Abstract »    Full Text »    PDF »
Glia-Synapse Interaction Through Ca2+-Permeable AMPA Receptors in Bergmann Glia.
M. Iino, K. Goto, W. Kakegawa, H. Okado, M. Sudo, S. Ishiuchi, A. Miwa, Y. Takayasu, I. Saito, K. Tsuzuki, et al. (2001)
Science 292, 926-929
   Abstract »    Full Text »    PDF »
The role of Ca2+ stores in the muscarinic inhibition of the K+ current IK(SO) in neonatal rat cerebellar granule cells.
D. F Boyd, J. A Millar, C. S Watkins, and A. Mathie (2000)
J. Physiol. 529, 321-331
   Abstract »    Full Text »    PDF »
AMPA-Kainate Subtypes of Glutamate Receptor in Rat Cerebral Microglia.
M. Noda, H. Nakanishi, J. Nabekura, and N. Akaike (2000)
J. Neurosci. 20, 251-258
   Abstract »    Full Text »    PDF »
Neuron-Glia Signaling via alpha 1 Adrenoceptor-Mediated Ca2+ Release in Bergmann Glial Cells In Situ.
A. Kulik, A. Haentzsch, M. Luckermann, W. Reichelt, and K. Ballanyi (1999)
J. Neurosci. 19, 8401-8408
   Abstract »    Full Text »    PDF »
Ca2+ permeability and kinetics of glutamate receptors in rat medial habenula neurones: implications for purinergic transmission in this nucleus.
S J Robertson, N Burnashev, and F A Edwards (1999)
J. Physiol. 518, 539-549
   Abstract »    Full Text »    PDF »
Differences in the Properties of Ionotropic Glutamate Synaptic Currents in Oxytocin and Vasopressin Neuroendocrine Neurons.
J. E. Stern, M. Galarreta, R. C. Foehring, S. Hestrin, and W. E. Armstrong (1999)
J. Neurosci. 19, 3367-3375
   Abstract »    Full Text »    PDF »
The Glutamate Receptor Ion Channels.
R. Dingledine, K. Borges, D. Bowie, and S. F. Traynelis (1999)
Pharmacol. Rev. 51, 7-62
   Abstract »    Full Text »    PDF »
AMPA Receptors: Players in Calcium-Mediated Neuronal Injury?.
H. L. Gaspary (1998)
Neuroscientist 4, 149-153
   Abstract »    PDF »
Intracellular Ca2+ regulation by the leech giant glial cell.
W. Nett and J. W Deitmer (1998)
J. Physiol. 507, 147-162
   Abstract »    Full Text »    PDF »
Glial Calcium: Homeostasis and Signaling Function.
A. VERKHRATSKY, R. K. ORKAND, and H. KETTENMANN (1998)
Physiol Rev 78, 99-141
   Abstract »    Full Text »    PDF »
Pharmacological Characterization of Na+ Influx via Voltage-Gated Na+ Channels in Spinal Cord Astrocytes.
C. R. Rose, B. R. Ransom, and S. G. Waxman (1997)
J Neurophysiol 78, 3249-3258
   Abstract »    Full Text »    PDF »
Intracellular Calcium Transients and Potassium Current Oscillations Evoked by Glutamate in Cultured Rat Astrocytes.
J. Chen, K. H. Backus, and J. W. Deitmer (1997)
J. Neurosci. 17, 7278-7287
   Abstract »    Full Text »    PDF »
Mechanisms of H+ and Na+ Changes Induced by Glutamate, Kainate, and D-Aspartate in Rat Hippocampal Astrocytes.
C. R. Rose and B. R. Ransom (1996)
J. Neurosci. 16, 5393-5404
   Abstract »    Full Text »    PDF »
Molecular diversity of glutamate receptors and implications for brain function.
S Nakanishi (1992)
Science 258, 597-603
   Abstract »    PDF »
Corrections and Clarifications.
(1992)
Science 257, 1190
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)