Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 29 May 1992:
Vol. 256. no. 5061, pp. 1331 - 1333
DOI: 10.1126/science.1598578
Prev | Table of Contents | Next

Articles

Science, Vol 256, Issue 5061, 1331-1333
Copyright © 1992 by American Association for the Advancement of Science

articles

Identification of a prenylation site in delta virus large antigen

JS Glenn, JA Watson, CM Havel, and JM White

Department of Pharmacology, University of California, San Francisco 94143-0450.

During replication, hepatitis delta virus (HDV) switches from production of small to large delta antigen. Both antigen isoforms have an HDV genome binding domain and are packaged into hepatitis B virus (HBV)-derived envelopes but differ at their carboxy termini. The large antigen was shown to contain a terminal CXXX box and undergo prenylation. The large, but not the small, antigen formed secreted particles when expressed singly with HBV surface antigen. Mutation of Cys211 in the CXXX box of the large antigen abolished both prenylation and particle formation, suggesting that this site is important for virion morphogenesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Clathrin-Mediated Post-Golgi Membrane Trafficking in the Morphogenesis of Hepatitis Delta Virus.
C. Huang, S. C. Chang, H.-C. Yang, C.-L. Chien, and M.-F. Chang (2009)
J. Virol. 83, 12314-12324
   Abstract »    Full Text »    PDF »
ERK1/2-Mediated Phosphorylation of Small Hepatitis Delta Antigen at Serine 177 Enhances Hepatitis Delta Virus Antigenomic RNA Replication.
Y.-S. Chen, W.-H. Huang, S.-Y. Hong, Y.-G. Tsay, and P.-J. Chen (2008)
J. Virol. 82, 9345-9358
   Abstract »    Full Text »    PDF »
Transcription of Subgenomic mRNA of Hepatitis Delta Virus Requires a Modified Hepatitis Delta Antigen That Is Distinct from Antigenomic RNA Synthesis.
C.-H. Tseng, K.-S. Jeng, and M. M. C. Lai (2008)
J. Virol. 82, 9409-9416
   Abstract »    Full Text »    PDF »
Hepatitis B Surface Antigen Levels and Sequences of Natural Hepatitis B Virus Variants Influence the Assembly and Secretion of Hepatitis D Virus.
H. H. Shih, K.-S. Jeng, W.-J. Syu, Y.-H. Huang, C.-W. Su, W.-L. Peng, I-J. Sheen, and J.-C. Wu (2008)
J. Virol. 82, 2250-2264
   Abstract »    Full Text »    PDF »
Large Hepatitis Delta Antigen Is a Novel Clathrin Adaptor-Like Protein.
C. Huang, S. C. Chang, I-C. Yu, Y.-G. Tsay, and M.-F. Chang (2007)
J. Virol. 81, 5985-5994
   Abstract »    Full Text »    PDF »
Induction of hepatitis D virus large antigen translocation to the cytoplasm by hepatitis B virus surface antigens correlates with endoplasmic reticulum stress and NF-{kappa}B activation.
I-C. Huang, C.-Y. Chien, C.-R. Huang, and S. J. Lo (2006)
J. Gen. Virol. 87, 1715-1723
   Abstract »    Full Text »    PDF »
A tryptophan-rich motif in the carboxyl terminus of the small envelope protein of hepatitis B virus is central to the assembly of hepatitis delta virus particles..
I. Komla-Soukha and C. Sureau (2006)
J. Virol. 80, 4648-4655
   Abstract »    Full Text »    PDF »
Prenylation-Defective Human Connexin32 Mutants Are Normally Localized and Function Equivalently to Wild-Type Connexin32 in Myelinating Schwann Cells.
Y. Huang, E. E. Sirkowski, J. T. Stickney, and S. S. Scherer (2005)
J. Neurosci. 25, 7111-7120
   Abstract »    Full Text »    PDF »
RNA Replication without RNA-Dependent RNA Polymerase: Surprises from Hepatitis Delta Virus.
M. M. C. Lai (2005)
J. Virol. 79, 7951-7958
   Full Text »    PDF »
Novel Nuclear Export Signal-Interacting Protein, NESI, Critical for the Assembly of Hepatitis Delta Virus.
Y.-H. Wang, S. C. Chang, C. Huang, Y.-P. Li, C.-H. Lee, and M.-F. Chang (2005)
J. Virol. 79, 8113-8120
   Abstract »    Full Text »    PDF »
Roles of Carboxyl-Terminal and Farnesylated Residues in the Functions of the Large Hepatitis Delta Antigen.
B. O'Malley and D. W. Lazinski (2005)
J. Virol. 79, 1142-1153
   Abstract »    Full Text »    PDF »
Hepatitis Delta Virus Antigen Is Methylated at Arginine Residues, and Methylation Regulates Subcellular Localization and RNA Replication.
Y.-J. Li, M. R. Stallcup, and M. M. C. Lai (2004)
J. Virol. 78, 13325-13334
   Abstract »    Full Text »    PDF »
Ser-123 of the large antigen of hepatitis delta virus modulates its cellular localization to the nucleolus, SC-35 speckles or the cytoplasm.
K.-P. Tan, K.-N. Shih, and S. J. Lo (2004)
J. Gen. Virol. 85, 1685-1694
   Abstract »    Full Text »    PDF »
Varied Immunity Generated in Mice by DNA Vaccines with Large and Small Hepatitis Delta Antigens.
Y.-H. Huang, J.-C. Wu, S.-C. Hsu, and W.-J. Syu (2003)
J. Virol. 77, 12980-12985
   Abstract »    Full Text »    PDF »
Chronic hepatitis delta virus infection with genotype IIb variant is correlated with progressive liver disease.
H. Watanabe, K. Nagayama, N. Enomoto, R. Chinzei, T. Yamashiro, N. Izumi, H. Yatsuhashi, T. Nakano, B. H. Robertson, H. Nakasone, et al. (2003)
J. Gen. Virol. 84, 3275-3289
   Abstract »    Full Text »    PDF »
Prenylation inhibitors: a novel class of antiviral agents.
S. Einav and J. S. Glenn (2003)
J. Antimicrob. Chemother. 52, 883-886
   Abstract »    Full Text »    PDF »
Determination of the Multimerization State of the Hepatitis Delta Virus Antigens In Vivo.
C. T. Cornillez-Ty and D. W. Lazinski (2003)
J. Virol. 77, 10314-10326
   Abstract »    Full Text »    PDF »
Role of N Glycosylation of Hepatitis B Virus Envelope Proteins in Morphogenesis and Infectivity of Hepatitis Delta Virus.
C. Sureau, C. Fournier-Wirth, and P. Maurel (2003)
J. Virol. 77, 5519-5523
   Abstract »    Full Text »    PDF »
Selective Strand Annealing and Selective Strand Exchange Promoted by the N-terminal Domain of Hepatitis Delta Antigen.
Z.-S. Huang, W.-H. Su, J.-L. Wang, and H.-N. Wu (2003)
J. Biol. Chem. 278, 5685-5693
   Abstract »    Full Text »    PDF »
A Prenylation Inhibitor Prevents Production of Infectious Hepatitis Delta Virus Particles.
B. B. Bordier, P. L. Marion, K. Ohashi, M. A. Kay, H. B. Greenberg, J. L. Casey, and J. S. Glenn (2002)
J. Virol. 76, 10465-10472
   Abstract »    Full Text »    PDF »
The Double-stranded RNA-activated Kinase, PKR, Can Phosphorylate Hepatitis D Virus Small Delta Antigen at Functional Serine and Threonine Residues.
C.-W. Chen, Y.-G. Tsay, H.-L. Wu, C.-H. Lee, D.-S. Chen, and P.-J. Chen (2002)
J. Biol. Chem. 277, 33058-33067
   Abstract »    Full Text »    PDF »
Unique Properties of the Large Antigen of Hepatitis Delta Virus.
G. Moraleda, S. Seeholzer, V. Bichko, R. Dunbrack, J. Otto, and J. Taylor (1999)
J. Virol. 73, 7147-7152
   Abstract »    Full Text »
The African Swine Fever Virus Prenyltransferase Is an Integral Membrane trans-Geranylgeranyl-diphosphate Synthase.
A. Alejo, G. Andres, E. Vinuela, and M. L. Salas (1999)
J. Biol. Chem. 274, 18033-18039
   Abstract »    Full Text »    PDF »
Use of a Prenylation Inhibitor as a Novel Antiviral Agent.
J. S. Glenn, J. C. Marsters Jr., and H. B. Greenberg (1998)
J. Virol. 72, 9303-9306
   Abstract »    Full Text »    PDF »
Identification and Characterization of the RNA Chaperone Activity of Hepatitis Delta Antigen Peptides.
Z.-S. Huang and H.-N. Wu (1998)
J. Biol. Chem. 273, 26455-26461
   Abstract »    Full Text »    PDF »
The Nucleolin Binding Activity of Hepatitis Delta Antigen Is Associated with Nucleolus Targeting.
C.-H. Lee, S. C. Chang, C.-J. Chen, and M.-F. Chang (1998)
J. Biol. Chem. 273, 7650-7656
   Abstract »    Full Text »    PDF »
Activation of Heterologous Gene Expression by the Large Isoform of Hepatitis Delta Antigen.
Y. Wei and D. Ganem (1998)
J. Virol. 72, 2089-2096
   Abstract »    Full Text »    PDF »
African Swine Fever Virus trans-Prenyltransferase.
A. Alejo, R. J. Yanez, J. M. Rodriguez, E. Vinuela, and M. L. Salas (1997)
J. Biol. Chem. 272, 9417-9423
   Abstract »    Full Text »    PDF »
The Hepatitis Delta Virus Large Antigen Is Farnesylated Both in Vitro and in Animal Cells.
J. C. Otto and P. J. Casey (1996)
J. Biol. Chem. 271, 4569-4572
   Abstract »    Full Text »    PDF »
Retina-specifically Expressed Novel Subtypes of Bovine Cyclophilin.
P. A. Ferreira, J. T. Hom, and W. L. Pak (1995)
J. Biol. Chem. 270, 23179-23188
   Abstract »    Full Text »    PDF »
Large Isoform of Hepatitis Delta Antigen Activates Serum Response Factor-associated Transcription.
T. Goto, N. Kato, S. K. Ono-Nita, H. Yoshida, M. Otsuka, Y. Shiratori, and M. Omata (2000)
J. Biol. Chem. 275, 37311-37316
   Abstract »    Full Text »    PDF »
A Novel Chromosome Region Maintenance 1-independent Nuclear Export Signal of the Large Form of Hepatitis Delta Antigen That Is Required for the Viral Assembly.
C.-H. Lee, S. C. Chang, C. H. H. Wu, and M.-F. Chang (2001)
J. Biol. Chem. 276, 8142-8148
   Abstract »    Full Text »    PDF »
The Nucleolar Phosphoprotein B23 Interacts with Hepatitis Delta Antigens and Modulates the Hepatitis Delta Virus RNA Replication.
W.-H. Huang, B. Y. M. Yung, W.-J. Syu, and Y.-H. W. Lee (2001)
J. Biol. Chem. 276, 25166-25175
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)