Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 22 May 1992:
Vol. 256. no. 5060, pp. 1213 - 1215
DOI: 10.1126/science.256.5060.1213
Prev | Table of Contents | Next

Articles

Role of CD8+ T Cells in Murine Experimental Allergic Encephalomyelitis

Hong Jiang 1, Sheng-le Zhang 1, and Benvenuto Pernis 1

1 Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032

The course of experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis, is affected by immunoregulatory T lymphocytes. When animals are immunized with encephalitogenic peptide of myelin basic protein and recover from the first episode of EAE, they become resistant to a second induction of this disease. Animals depleted of CD8+ T cells by antibody-mediated clearance were used to examine the role of CD8+ T cells in EAE. These cells were found to be major participants in the resistance to a second induction of EAE but were not essential for spontaneous recovery from the first episode of the disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The specificity of T cell regulation that enables self-nonself discrimination in the periphery.
Y. Wu, Z. Zheng, Y. Jiang, L. Chess, and H. Jiang (2009)
PNAS 106, 534-539
   Abstract »    Full Text »    PDF »
The frequency of regulatory CD3+CD8+CD28-CD25+ T lymphocytes in human peripheral blood increases with age.
R. Simone, A. Zicca, and D. Saverino (2008)
J. Leukoc. Biol. 84, 1454-1461
   Abstract »    Full Text »    PDF »
CD8+CD28-, suppressive T cells in systemic lupus erythematosus.
A Tulunay, S Yavuz, H Direskeneli, and E Eksioglu-Demiralp (2008)
Lupus 17, 630-637
   Abstract »    PDF »
Essential Role of CD8+CD122+ Regulatory T Cells in the Recovery from Experimental Autoimmune Encephalomyelitis.
Y.-H. Lee, Y. Ishida, M. Rifa'i, Z. Shi, K.-i. Isobe, and H. Suzuki (2008)
J. Immunol. 180, 825-832
   Abstract »    Full Text »    PDF »
Perceiving the avidity of T cell activation can be translated into peripheral T cell regulation.
W. Chen, L. Zhang, B. Liang, Y. Saenger, J. Li, L. Chess, and H. Jiang (2007)
PNAS 104, 20472-20477
   Abstract »    Full Text »    PDF »
Crucial Role of Apoptosis in the Resolution of Experimental Autoimmune Anterior Uveitis.
P. Jha, B. Matta, V. Lyzogubov, R. Tytarenko, P. S. Bora, and N. S. Bora (2007)
Invest. Ophthalmol. Vis. Sci. 48, 5091-5100
   Abstract »    Full Text »    PDF »
Anti-TCR Antibody Treatment Activates a Novel Population of Nonintestinal CD8{alpha}{alpha}+TCR{alpha}beta+ Regulatory T Cells and Prevents Experimental Autoimmune Encephalomyelitis.
X. Tang, I. Maricic, and V. Kumar (2007)
J. Immunol. 178, 6043-6050
   Abstract »    Full Text »    PDF »
Minimally Activated CD8 Autoreactive T Cells Specific for IRBP Express a High Level of Foxp3 and Are Functionally Suppressive.
Y. Peng, H. Shao, Y. Ke, P. Zhang, G. Han, H. J. Kaplan, and D. Sun (2007)
Invest. Ophthalmol. Vis. Sci. 48, 2178-2184
   Abstract »    Full Text »    PDF »
T Cell Repertoire Diversity Is Required for Relapses in Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis.
N. Fazilleau, C. Delarasse, I. Motta, S. Fillatreau, M.-L. Gougeon, P. Kourilsky, D. Pham-Dinh, and J. M. Kanellopoulos (2007)
J. Immunol. 178, 4865-4875
   Abstract »    Full Text »    PDF »
Regulation of Immunity by a Novel Population of Qa-1-Restricted CD8{alpha}{alpha}+TCR{alpha}beta+ T Cells.
X. Tang, I. Maricic, N. Purohit, B. Bakamjian, L. M. Reed-Loisel, T. Beeston, P. Jensen, and V. Kumar (2006)
J. Immunol. 177, 7645-7655
   Abstract »    Full Text »    PDF »
Induction of CD8+ regulatory T cells in the intestine by Heligmosomoides polygyrus infection..
A. Metwali, T. Setiawan, A. M. Blum, J. Urban, D. E. Elliott, L. Hang, and J. V. Weinstock (2006)
Am J Physiol Gastrointest Liver Physiol 291, G253-G259
   Abstract »    Full Text »    PDF »
Regulation of immune responses by T cells..
H. Jiang and L. Chess (2006)
N. Engl. J. Med. 354, 1166-1176
   Full Text »    PDF »
Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?.
M. A. Friese and L. Fugger (2005)
Brain 128, 1747-1763
   Abstract »    Full Text »    PDF »
Peripheral CD8+CD25+ T Lymphocytes from MHC Class II-Deficient Mice Exhibit Regulatory Activity.
B. Bienvenu, B. Martin, C. Auffray, C. Cordier, C. Becourt, and B. Lucas (2005)
J. Immunol. 175, 246-253
   Abstract »    Full Text »    PDF »
Peptide-Specific CD8 T Regulatory Cells Use IFN-{gamma} to Elaborate TGF-{beta}-Based Suppression.
L. Myers, M. Croft, B. S. Kwon, R. S. Mittler, and A. T. Vella (2005)
J. Immunol. 174, 7625-7632
   Abstract »    Full Text »    PDF »
Complementary Contribution of CD4 and CD8 T Lymphocytes to T-Cell Infiltration of the Intact and the Degenerative Spinal Cord.
M. Bradl, J. Bauer, A. Flugel, H. Wekerle, and H. Lassmann (2005)
Am. J. Pathol. 166, 1441-1450
   Abstract »    Full Text »    PDF »
MMP-2 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP-9 expression and activity.
J. ESPARZA, M. KRUSE, J. LEE, M. MICHAUD, and J. A. MADRI (2004)
FASEB J 18, 1682-1691
   Abstract »    Full Text »    PDF »
IL-10 Plays an Important Role in the Homeostatic Regulation of the Autoreactive Repertoire in Naive Mice.
A. C. Anderson, J. Reddy, R. Nazareno, R. A. Sobel, L. B. Nicholson, and V. K. Kuchroo (2004)
J. Immunol. 173, 828-834
   Abstract »    Full Text »    PDF »
High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay.
M. P. Crawford, S. X. Yan, S. B. Ortega, R. S. Mehta, R. E. Hewitt, D. A. Price, P. Stastny, D. C. Douek, R. A. Koup, M. K. Racke, et al. (2004)
Blood 103, 4222-4231
   Abstract »    Full Text »    PDF »
CD8+ T Lymphocytes Regulating Th2 Pathology Escape Neonatal Tolerization.
B. Adams, N. Nagy, F. Paulart, M.-L. Vanderhaeghen, M. Goldman, and V. Flamand (2003)
J. Immunol. 171, 5071-5076
   Abstract »    Full Text »    PDF »
Regulatory CD8+ T cells fine-tune the myelin basic protein-reactive T cell receptor V{beta} repertoire during experimental autoimmune encephalomyelitis.
H. Jiang, S. Curran, E. Ruiz-Vazquez, B. Liang, R. Winchester, and L. Chess (2003)
PNAS 100, 8378-8383
   Abstract »    Full Text »    PDF »
Development of Infectious Tolerance After Donor-Specific Transfusion and Rat Heart Transplantation.
M. Kataoka, J. A. Margenthaler, G. Ku, and M. W. Flye (2003)
J. Immunol. 171, 204-211
   Abstract »    Full Text »    PDF »
Regulatory T Cells Control Autoimmunity In Vivo by Inducing Apoptotic Depletion of Activated Pathogenic Lymphocytes.
L. T. Madakamutil, I. Maricic, E. Sercarz, and V. Kumar (2003)
J. Immunol. 170, 2985-2992
   Abstract »    Full Text »    PDF »
Phenotypes of T Cells Infiltrating the Eyes in Autoimmune Anterior Uveitis Associated with EAE.
X. Zhang, S. Jiang, M. Manczak, B. Sugden, and G. Adamus (2002)
Invest. Ophthalmol. Vis. Sci. 43, 1499-1508
   Abstract »    Full Text »    PDF »
CD8+ T cells are not necessary for 1alpha ,25-dihydroxyvitamin D3 to suppress experimental autoimmune encephalomyelitis in mice.
T. F. Meehan and H. F. DeLuca (2002)
PNAS 99, 5557-5560
   Abstract »    Full Text »    PDF »
Antigenic Mimicry: Onchocerca volvulus Antigen-Specific T Cells and Ocular Inflammation.
N. M. McKechnie, W. Gurr, H. Yamada, D. Copland, and G. Braun (2002)
Invest. Ophthalmol. Vis. Sci. 43, 411-418
   Abstract »    Full Text »    PDF »
Natural Killer T Cell Activation Protects Mice Against Experimental Autoimmune Encephalomyelitis.
A. K. Singh, M. T. Wilson, S. Hong, D. Olivares-Villagomez, C. Du, A. K. Stanic, S. Joyce, S. Sriram, Y. Koezuka, and L. Van Kaer (2001)
J. Exp. Med. 194, 1801-1811
   Abstract »    Full Text »    PDF »
Induction of TCR V{beta}-Specific CD8+ CTLs by TCR V{beta}-Derived Peptides Bound to HLA-E.
J. Li, I. Goldstein, E. Glickman-Nir, H. Jiang, and L. Chess (2001)
J. Immunol. 167, 3800-3808
   Abstract »    Full Text »    PDF »
A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis.
E. S. Huseby, D. Liggitt, T. Brabb, B. Schnabel, C. Ohlen, and J. Goverman (2001)
J. Exp. Med. 194, 669-676
   Abstract »    Full Text »    PDF »
Induction of a type 1 regulatory CD4 T cell response following V{beta}8.2 DNA vaccination results in immune deviation and protection from experimental autoimmune encephalomyelitis.
V. Kumar, J. Maglione, J. Thatte, B. Pederson, E. Sercarz, and E. S. Ward (2001)
Int. Immunol. 13, 835-841
   Abstract »    Full Text »    PDF »
Absence of Monocyte Chemoattractant Protein 1 in Mice Leads to Decreased Local Macrophage Recruitment and Antigen-Specific T Helper Cell Type 1 Immune Response in Experimental Autoimmune Encephalomyelitis.
D. Huang, J. Wang, P. Kivisakk, B. J. Rollins, and R. M. Ransohoff (2001)
J. Exp. Med. 193, 713-726
   Abstract »    Full Text »    PDF »
Apoptosis of thyrocytes and effector cells during induction and resolution of granulomatous experimental autoimmune thyroiditis.
H. Tang, K. Chen, Y. Wei, G. C. Sharp, L. McKee, and H. Braley-Mullen (2000)
Int. Immunol. 12, 1629-1639
   Abstract »    Full Text »    PDF »
Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction.
H. Babbe, A. Roers, A. Waisman, H. Lassmann, N. Goebels, R. Hohlfeld, M. Friese, R. Schroder, M. Deckert, S. Schmidt, et al. (2000)
J. Exp. Med. 192, 393-404
   Abstract »    Full Text »    PDF »
Cutting Edge: Myelin Basic Protein-Specific Cytotoxic T Cell Tolerance Is Maintained In Vivo by a Single Dominant Epitope in H-2k Mice.
E. S. Huseby, C. Ohlen, and J. Goverman (1999)
J. Immunol. 163, 1115-1118
   Abstract »    Full Text »    PDF »
Induction or Protection from Experimental Autoimmune Encephalomyelitis Depends on the Cytokine Secretion Profile of TCR Peptide-Specific Regulatory CD4 T Cells.
V. Kumar and E. Sercarz (1998)
J. Immunol. 161, 6585-6591
   Abstract »    Full Text »    PDF »
Regulatory CD4+ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein-specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis.
D. Olivares-Villagomez, Y. Wang, and J. J. Lafaille (1998)
J. Exp. Med. 188, 1883-1894
   Abstract »    Full Text »    PDF »
Immunopathology of Herpetic Stromal Keratitis: Discordance in CD4+ T Cell Function Between Euthymic Host and Reconstituted SCID Recipients.
J. Thomas and B. T. Rouse (1998)
J. Immunol. 160, 3965-3970
   Abstract »    Full Text »    PDF »
T cell vaccination induces T cell receptor Vbeta -specific Qa-1-restricted regulatory CD8+ T cells.
H. Jiang, H. Kashleva, L.-X. Xu, J. Forman, L. Flaherty, B. Pernis, N. S. Braunstein, and L. Chess (1998)
PNAS 95, 4533-4537
   Abstract »    Full Text »    PDF »
MHC Class I-Restricted Lysis of Human Oligodendrocytes by Myelin Basic Protein Peptide-Specific CD8 T Lymphocytes.
A. Jurewicz, W. E. Biddison, and J. P. Antel (1998)
J. Immunol. 160, 3056-3059
   Abstract »    Full Text »    PDF »
Regulation of Experimental Autoimmune Encephalomyelitis by Natural Killer (NK) Cells.
B.-n. Zhang, T. Yamamura, T. Kondo, M. Fujiwara, and T. Tabira (1997)
J. Exp. Med. 186, 1677-1687
   Abstract »    Full Text »    PDF »
Requirement for CD8+ cells in T cell receptor peptide-induced clonal unresponsiveness.
A Gaur, G Ruberti, R Haspel, J. Mayer, and C. Fathman (1993)
Science 259, 91-94
   Abstract »    PDF »
Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8-/- Mice.
D.-R. Koh, W.-P. Fung-Leung, A. Ho, D. Gray, H. Acha-Orbea, and T.-W. Mak (1992)
Science 256, 1210-1213
   Abstract »    PDF »
CD8+ T cells are not necessary for 1alpha ,25-dihydroxyvitamin D3 to suppress experimental autoimmune encephalomyelitis in mice.
T. F. Meehan and H. F. DeLuca (2002)
PNAS 99, 5557-5560
   Abstract »    Full Text »    PDF »
CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice.
H. Jiang, N. S. Braunstein, B. Yu, R. Winchester, and L. Chess (2001)
PNAS 98, 6301-6306
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)