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Science 1 May 1992:
Vol. 256. no. 5057, pp. 675 - 677
DOI: 10.1126/science.1585183
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Articles

Science, Vol 256, Issue 5057, 675-677
Copyright © 1992 by American Association for the Advancement of Science

articles

Modality-specific retrograde amnesia of fear

JJ Kim and MS Fanselow

Department of Psychology, University of California, Los Angeles 90024.

Emotional responses such as fear are rapidly acquired through classical conditioning. This report examines the neural substrate underlying memory of acquired fear. Rats were classically conditioned to fear both tone and context through the use of aversive foot shocks. Lesions were made in the hippocampus either 1, 7, 14, or 28 days after training. Contextual fear was abolished in the rats that received lesions 1 day after fear conditioning. However, rats for which the interval between learning and hippocampal lesions was longer retained significant contextual fear memory. In the same animals, lesions did not affect fear response to the tone at any time. These results indicate that fear memory is not a single process and that the hippocampus may have a time-limited role in associative fear memories evoked by polymodal (contextual) but not unimodal (tone) sensory stimuli.


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Neural Substrates of Eyeblink Conditioning: Acquisition and Retention.
K. M. Christian and R. F. Thompson (2003)
Learn. Mem. 10, 427-455
   Abstract »    Full Text »    PDF »
Loss of Ca2+/Calmodulin Kinase Kinase {beta} Affects the Formation of Some, But Not All, Types of Hippocampus-Dependent Long-Term Memory.
M. Peters, K. Mizuno, L. Ris, M. Angelo, E. Godaux, and K. P. Giese (2003)
J. Neurosci. 23, 9752-9760
   Abstract »    Full Text »    PDF »
Trace but not delay fear conditioning requires attention and the anterior cingulate cortex.
C. J. Han, C. M. O'Tuathaigh, L. van Trigt, J. J. Quinn, M. S. Fanselow, R. Mongeau, C. Koch, and D. J. Anderson (2003)
PNAS 100, 13087-13092
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Sleep Deprivation Causes Behavioral, Synaptic, and Membrane Excitability Alterations in Hippocampal Neurons.
C. M. McDermott, G. J. LaHoste, C. Chen, A. Musto, N. G. Bazan, and J. C. Magee (2003)
J. Neurosci. 23, 9687-9695
   Abstract »    Full Text »    PDF »


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