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Science 1 May 1992:
Vol. 256. no. 5057, pp. 665 - 667
DOI: 10.1126/science.1585181
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Articles

Science, Vol 256, Issue 5057, 665-667
Copyright © 1992 by American Association for the Advancement of Science

articles

DNA hydrolyzing autoantibodies

AM Shuster, GV Gololobov, OA Kvashuk, AE Bogomolova, IV Smirnov, and AG Gabibov

V.A. Engelhardt Institute of Molecular Biology, Academy of Sciences of Russia, Moscow.

A DNA-nicking activity was detected in the sera of patients with various autoimmune pathologies and was shown to be a property of autoantibodies. The DNA hydrolyzing activity, which was purified by affinity and high-performance liquid chromatography, corresponded in size to immunoglobulin M (IgM) and IgG and had a positive response to antibodies to human IgG. The DNA hydrolyzing autoantibodies were stable to acid shock and yielded a DNA degradation pattern that was different from that of deoxyribonuclease (DNase) I and blood DNase.


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