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Science 24 April 1992:
Vol. 256. no. 5056, pp. 532 - 535
DOI: 10.1126/science.1373909

Articles

Science, Vol 256, Issue 5056, 532-535
Copyright © 1992 by American Association for the Advancement of Science


articles

Regulation of arterial tone by activation of calcium-dependent potassium channels

JE Brayden and MT Nelson

Department of Pharmacology, University of Vermont, Colchester 05446.

Blood pressure and tissue perfusion are controlled in part by the level of intrinsic (myogenic) vascular tone. However, many of the molecular determinants of this response are unknown. Evidence is now presented that the degree of myogenic tone is regulated in part by the activation of large-conductance calcium-activated potassium channels in arterial smooth muscle. Tetraethylammonium ion (TEA+) and charybdotoxin (CTX), at concentrations that block calcium-activated potassium channels in smooth muscle cells isolated from cerebral arteries, depolarized and constricted pressurized cerebral arteries with myogenic tone. Both TEA+ and CTX had little effect on arteries when intracellular calcium was reduced by lowering intravascular pressure or by blocking calcium channels. Elevation of intravascular pressure through membrane depolarization and an increase in intracellular calcium may activate calcium-activated potassium channels. Thus, these channels may serve as a negative feedback pathway to control the degree of membrane depolarization and vasoconstriction.


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J Appl Physiol 92, 550-558
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Micromolar Ca2+ from sparks activates Ca2+-sensitive K+ channels in rat cerebral artery smooth muscle.
G. J. Perez, A. D. Bonev, and M. T. Nelson (2001)
Am J Physiol Cell Physiol 281, C1769-C1775
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Homogeneous segmental profile of carbon monoxide-mediated pulmonary vasodilation in rats.
J. S. Naik and B. R. Walker (2001)
Am J Physiol Lung Cell Mol Physiol 281, L1436-L1443
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Membrane depolarization, elevated Ca2+ entry, and gene expression in cerebral arteries of hypertensive rats.
G. C. Wellman, L. Cartin, D. M. Eckman, A. S. Stevenson, C. M. Saundry, W. J. Lederer, and M. T. Nelson (2001)
Am J Physiol Heart Circ Physiol 281, H2559-H2567
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Calcium Sparks Unleashed in Vascular Smooth Muscle: Lessons From the RyR3 Knockout Mouse.
H. J. Knot (2001)
Circ. Res. 89, 941-943
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{beta}1-subunit of BK channels regulates arterial wall [Ca2+] and diameter in mouse cerebral arteries.
M. Lohn, B. Lauterbach, H. Haller, O. Pongs, F. C. Luft, and M. Gollasch (2001)
J Appl Physiol 91, 1350-1354
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Signal Transduction in Smooth Muscle: Invited Review: Arteriolar smooth muscle mechanotransduction: Ca2+ signaling pathways underlying myogenic reactivity.
M. A. Hill, H. Zou, S. J. Potocnik, G. A. Meininger, and M. J. Davis (2001)
J Appl Physiol 91, 973-983
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Intravascular pressure regulates local and global Ca2+ signaling in cerebral artery smooth muscle cells.
J. H. Jaggar (2001)
Am J Physiol Cell Physiol 281, C439-C448
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Dihydroxyeicosatrienoic acids are potent activators of Ca2+-activated K+ channels in isolated rat coronary arterial myocytes.
T. Lu, P. V G Katakam, M. VanRollins, N. L Weintraub, A. A Spector, and H.-C. Lee (2001)
J. Physiol. 534, 651-667
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Expression and function of native potassium channel (KV{alpha}1) subunits in terminal arterioles of rabbit.
A Cheong, A M Dedman, and D J Beech (2001)
J. Physiol. 534, 691-700
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