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Science 17 April 1992:
Vol. 256. no. 5055, pp. 373 - 377
DOI: 10.1126/science.256.5055.373
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Articles

Alternative Forms of Max as Enhancers or Suppressors of Myc-Ras Cotransformation

Tomi P. Mäkelä 1, Päivi J. Koskinen 1, Imre Västrik 1, and Kari Alitalo 1

1 Laboratory of Cancer Biology, Departments Virology and Pathology, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki, Finland

Max is a basic-helix-loop-helix-Ieucine zipper protein capable of forming sequence-specific DNA binding complexes with Myc proteins. An alternatively spliced messenger RNA has been identified that encodes a form of Max truncated at the COOH-terminus. This DgrMax protein retained the ability to bind to the CACGTG motif in a complex with c-Myc but lacks the nuclear localization signal and the putative regulatory domain of Max. When tested in a myc-ras cotransformation assay in rat embryo fibroblasts, Max suppressed, whereas DgrMax enhanced, transformation. Thus, the maxgene may encode both a negative and a positive regulator of c-Myc function.


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