Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 10 April 1992:
Vol. 256. no. 5054, pp. 243 - 245
DOI: 10.1126/science.1314424
Prev | Table of Contents | Next

Articles

Science, Vol 256, Issue 5054, 243-245
Copyright © 1992 by American Association for the Advancement of Science

articles

Lithium-sensitive production of inositol phosphates during amphibian embryonic mesoderm induction

JA Maslanski, L Leshko, and WB Busa

Department of Biology, Johns Hopkins University, Baltimore, MD 21218.

Mesoderm induction and body axis determination in frog (Xenopus) embryos are thought to involve growth factor-mediated cell-cell signaling, but the signal transduction pathways are unknown. Li+, which inhibits the polyphosphoinositide (PI) cycle signal transduction pathway in many cells, also disrupts axis determination and mesoderm induction. Amounts of the PI cycle-derived second messenger, inositol 1,4,5-trisphosphate, increased during mesoderm induction in normal embryos; addition of Li+ inhibited the embryonic inositol monophosphatase and reversed this increase. Embryonic PI cycle activity thus shows characteristics that indicate it may function in mesoderm induction and axis determination.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Calcium dynamics integrated into signalling pathways that influence vertebrate axial patterning.
C. M Freisinger, I. Schneider, T. A Westfall, and D. C Slusarski (2008)
Phil Trans R Soc B 363, 1377-1385
   Abstract »    Full Text »    PDF »
Molecular and Functional Characterization of Inositol Trisphosphate Receptors during Early Zebrafish Development.
R. Ashworth, B. Devogelaere, J. Fabes, R. E. Tunwell, K. R. Koh, H. De Smedt, and S. Patel (2007)
J. Biol. Chem. 282, 13984-13993
   Abstract »    Full Text »    PDF »
Heteromeric, but Not Homomeric, Connexin Channels Are Selectively Permeable to Inositol Phosphates.
W. A. Ayad, D. Locke, I. V. Koreen, and A. L. Harris (2006)
J. Biol. Chem. 281, 16727-16739
   Abstract »    Full Text »    PDF »
Calcium at Fertilization and in Early Development.
M. Whitaker (2006)
Physiol Rev 86, 25-88
   Abstract »    Full Text »    PDF »
Statistical evaluation of differential expression on cDNA nylon arrays with replicated experiments.
R. Herwig, P. Aanstad, M. Clark, and H. Lehrach (2001)
Nucleic Acids Res. 29, e117
   Abstract »    Full Text »    PDF »
Role of Inositol 1,4,5-Trisphosphate Receptor in Ventral Signaling in Xenopus Embryos.
S. Kume, A. Muto, T. Inoue, K. Suga, H. Okano, and K. Mikoshiba (1997)
Science 278, 1940-1943
   Abstract »    Full Text »
Gene Cloning and Characterization of CDP-diacylglycerol Synthase from Rat Brain.
S. Saito, K. Goto, A. Tonosaki, and H. Kondo (1997)
J. Biol. Chem. 272, 9503-9509
   Abstract »    Full Text »    PDF »
Modulation of Xenopus embryo mesoderm-specific gene expression and dorsoanterior patterning by receptors that activate the phosphatidylinositol cycle signal transduction pathway.
K. Ault, G Durmowicz, A Galione, P. Harger, and W. Busa (1996)
Development 122, 2033-2041
   Abstract »    PDF »
Signal Transduction Pathways: Molecular Targets for Lithium's Actions.
H. K. Manji, W. Z. Potter, and R. H. Lenox (1995)
Arch Gen Psychiatry 52, 531-543
   Abstract »    PDF »
Effect of activin and lithium on isolated Xenopus animal blastomeres and response alteration at the midblastula transition.
K Kinoshita and M Asashima (1995)
Development 121, 1581-1589
   Abstract »    PDF »
Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3.
S. Pierce and D Kimelman (1995)
Development 121, 755-765
   Abstract »    PDF »
Intracellular free calcium oscillations in normal and cleavage-blocked embryos and artificially activated eggs of Xenopus laevis.
T. Keating, R. Cork, and K. Robinson (1994)
J. Cell Sci. 107, 2229-2237
   Abstract »    PDF »
Cortical cytoplasm, which induces dorsal axis formation in Xenopus, is inactivated by UV irradiation of the oocyte.
T Holowacz and R. Elinson (1993)
Development 119, 277-285
   Abstract »    PDF »
Mesoderm formation in Xenopus ectodermal explants overexpressing Xwnt8: evidence for a cooperating signal reaching the animal pole by gastrulation.
S. Sokol (1993)
Development 118, 1335-1342
   Abstract »    PDF »
Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish.
S. Stachel, D. Grunwald, and P. Myers (1993)
Development 117, 1261-1274
   Abstract »    PDF »
Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus..
J L Christian and R T Moon (1993)
Genes & Dev. 7, 13-28
   Abstract »    PDF »
Role of SH2-containing Proteins in Cellular Signaling by Receptor Tyrosine Kinases.
J. Schlessinger, M. Mohammadi, B. Margolis, and A. Ullrich (1992)
Cold Spring Harb Symp Quant Biol 57, 67-74
   Abstract »    PDF »
Calmodulin Differentially Modulates Smad1 and Smad2 Signaling.
A. Scherer and J. M. Graff (2000)
J. Biol. Chem. 275, 41430-41438
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)