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Science 10 April 1992:
Vol. 256. no. 5054, pp. 240 - 243
DOI: 10.1126/science.1314423
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Articles

Science, Vol 256, Issue 5054, 240-243
Copyright © 1992 by American Association for the Advancement of Science

articles

Body-wall muscle formation in Caenorhabditis elegans embryos that lack the MyoD homolog hlh-1

L Chen, M Krause, B Draper, H Weintraub, and A Fire

Carnegie Institution of Washington, Baltimore, MD 21210.

The myoD family of DNA binding proteins has been implicated in the control of myogenesis in a variety of organisms. Searches for homologs in the nematode Caenorhabditis elegans yielded only one gene, designated hlh-1, expressed in body-wall muscle cells and their precursors. To assess the role of hlh-1 in C. elegans myogenesis, genetic deficiencies spanning the hlh-1 locus were isolated after gamma irradiation. Embryos homozygous for these deficiencies exhibited extensive body-wall muscle differentiation, including expression of several characteristic myofilament proteins and weak contracile behavior. Thus, zygotic hlh-1 expression was not required for body-wall muscle precursors to adopt muscle cell fates.


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