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Science 10 April 1992:
Vol. 256. no. 5054, pp. 225 - 228
DOI: 10.1126/science.1373522
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Articles

Science, Vol 256, Issue 5054, 225-228
Copyright © 1992 by American Association for the Advancement of Science

articles

Cloning and characterization of inducible nitric oxide synthase from mouse macrophages

QW Xie, HJ Cho, J Calaycay, RA Mumford, KM Swiderek, TD Lee, A Ding, T Troso, and C Nathan

Beatrice and Samuel A. Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, NY 10021.

Nitric oxide (NO) conveys a variety of messages between cells, including signals for vasorelaxation, neurotransmission, and cytotoxicity. In some endothelial cells and neurons, a constitutive NO synthase is activated transiently by agonists that elevate intracellular calcium concentrations and promote the binding of calmodulin. In contrast, in macrophages, NO synthase activity appears slowly after exposure of the cells to cytokines and bacterial products, is sustained, and functions independently of calcium and calmodulin. A monospecific antibody was used to clone complementary DNA that encoded two isoforms of NO synthase from immunologically activated mouse macrophages. Liquid chromatography-mass spectrometry was used to confirm most of the amino acid sequence. Macrophage NO synthase differs extensively from cerebellar NO synthase. The macrophage enzyme is immunologically induced at the transcriptional level and closely resembles the enzyme in cytokine-treated tumor cells and inflammatory neutrophils.


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Infect. Immun. 71, 4917-4924
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Inducible Nitric Oxide Synthase in the Tuberculous Human Lung.
C. Nathan (2002)
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Inhibition of Inducible Nitric-Oxide Synthase Expression by Silymarin in Lipopolysaccharide-Stimulated Macrophages.
J. S. Kang, Y. J. Jeon, H. M. Kim, S. H. Han, and K.-H. Yang (2002)
J. Pharmacol. Exp. Ther. 302, 138-144
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Cutting Edge: Urease Release by Helicobacter pylori Stimulates Macrophage Inducible Nitric Oxide Synthase.
A. P. Gobert, B. D. Mersey, Y. Cheng, D. R. Blumberg, J. C. Newton, and K. T. Wilson (2002)
J. Immunol. 168, 6002-6006
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Effect of ursodeoxycholic acid on methionine adenosyltransferase activity and hepatic glutathione metabolism in rats.
C M Rodriguez-Ortigosa, R N Cincu, S Sanz, F Ruiz, J Quiroga, and J Prieto (2002)
Gut 50, 701-706
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Expression of Nitric Oxide Synthases in Rat Adrenal Zona Fasciculata Cells.
C. B. Cymeryng, S. P. Lotito, C. Colonna, C. Finkielstein, Y. Pomeraniec, N. Grion, L. Gadda, P. Maloberti, and E. J. Podesta (2002)
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The quantity of nitric oxide released by macrophages regulates Chlamydia-induced disease.
J. Huang, F. J. DeGraves, S. D. Lenz, D. Gao, P. Feng, D. Li, T. Schlapp, and B. Kaltenboeck (2002)
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Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon {gamma}.
H Tilg, C van Montfrans, A van den Ende, A Kaser, S J H van Deventer, S Schreiber, M Gregor, O Ludwiczek, P Rutgeerts, C Gasche, et al. (2002)
Gut 50, 191-195
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J. Pleiner, E. Heere-Ress, H. Langenberger, A. E. Sieder, M. Bayerle-Eder, F. Mittermayer, G. Fuchsjager-Mayrl, J. Bohm, B. Jansen, and M. Wolzt (2002)
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J. Biol. Chem. 276, 47950-47957
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Bioenergetics in cardiac hypertrophy: mitochondrial respiration as a pathological target of NO{middle dot}.
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J. Leukoc. Biol. 70, 510-517
   Abstract »    Full Text »    PDF »
Identification of Residues Critical for Enzymatic Activity in the Domain Encoded by Exons 8 and 9 of the Human Inducible Nitric Oxide Synthase.
N. T. Eissa, C. M. Haggerty, C. D. Palmer, W. Patton, and J. Moss (2001)
Am. J. Respir. Cell Mol. Biol. 24, 616-620
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Intersection of Interferon and Hypoxia Signal Transduction Pathways in Nitric Oxide-induced Tumor Apoptosis.
D. S. Tendler, C. Bao, T. Wang, E. L. Huang, E. A. Ratovitski, D. A. Pardoll, and C. J. Lowenstein (2001)
Cancer Res. 61, 3682-3688
   Abstract »    Full Text »
Nuclear Factor-kappa B Mediates Simultaneous Induction of Inducible Nitric-Oxide Synthase and Up-Regulation of the Cationic Amino Acid Transporter CAT-2B in Rat Alveolar Macrophages.
R. Hammermann, M. D. M. Dreißig, J. Mössner, M. Fuhrmann, L. Berrino, M. Göthert, and K. Racké (2001)
Mol. Pharmacol. 58, 1294-1302
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Inducible Nitric Oxide Synthase Neutralizes Carbamoylating Potential of 1,3-Bis(2-chloroethyl)-1-nitrosourea in C6 Glioma Cells.
J.-H. Yin, D.-I Yang, H. Chou, E. M. Thompson, J. Xu, and C. Y. Hsu (2001)
J. Pharmacol. Exp. Ther. 297, 308-315
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Down-Regulation of Inducible Nitric-Oxide Synthase (NOS-2) During Parasite-Induced Gut Inflammation: A Path to Identify a Selective NOS-2 Inhibitor.
K. Bian, Y. Harari, M. Zhong, M. Lai, G. Castro, N. Weisbrodt, and F. Murad (2001)
Mol. Pharmacol. 59, 939
   Abstract »    Full Text »
Innate resistance to flavivirus infection in mice controlled by Flv is nitric oxide-independent.
O. J. Silvia, G. R. Shellam, and N. Urosevic (2001)
J. Gen. Virol. 82, 603-607
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IFN-{gamma} + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38mapk in a mouse macrophage cell line.
E. D. Chan and D. W. H. Riches (2001)
Am J Physiol Cell Physiol 280, C441-C450
   Abstract »    Full Text »    PDF »
Inducible nitric oxide synthase: a tissue-specific affair?.
S. J. Wort, J. A. Mitchell, and T. W. Evans (2001)
Am J Physiol Lung Cell Mol Physiol 280, L387-L389
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Role of Nitric Oxide Synthase Type 2 in Acute Infection with Murine Cytomegalovirus.
S. Noda, K. Tanaka, S.-a. Sawamura, M. Sasaki, T. Matsumoto, K. Mikami, Y. Aiba, H. Hasegawa, N. Kawabe, and Y. Koga (2001)
J. Immunol. 166, 3533-3541
   Abstract »    Full Text »    PDF »
Effect of culture PO2 on macrophage (RAW 264.7) nitric oxide production.
C. M. Otto and J. E. Baumgardner (2001)
Am J Physiol Cell Physiol 280, C280-C287
   Abstract »    Full Text »    PDF »
Endothelial Nitric Oxide Synthase Gene-Deficient Mice Demonstrate Marked Retardation in Postnatal Bone Formation, Reduced Bone Volume, and Defects in Osteoblast Maturation and Activity.
J. Aguirre, L. Buttery, M. O'Shaughnessy, F. Afzal, I. Fernandez de Marticorena, M. Hukkanen, P. Huang, I. MacIntyre, and J. Polak (2001)
Am. J. Pathol. 158, 247-257
   Abstract »    Full Text »    PDF »
Activation of Nuclear Factor kappa B and Induction of Inducible Nitric Oxide Synthase by Ureaplasma urealyticum in Macrophages.
Y.-H. Li, Z.-Q. Yan, J. S. Jensen, K. Tullus, and A. Brauner (2000)
Infect. Immun. 68, 7087-7093
   Abstract »    Full Text »    PDF »
Novel Neurotransmitters and Their Neuropsychiatric Relevance.
S. H. Snyder and C. D. Ferris (2000)
Am J Psychiatry 157, 1738-1751
   Abstract »    Full Text »


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