Science 3 April 1992: Vol. 256. no. 5053, pp. 97 - 100 DOI: 10.1126/science.1373520

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Articles

Inflammatory Role of ASC in Antigen-Induced Arthritis Is Independent of Caspase-1, NALP-3, and IPAF.

L. Kolly, M. Karababa, L. A. B. Joosten, S. Narayan, R. Salvi, V. Petrilli, J. Tschopp, W. B. van den Berg, A. K.-L. So, and N. Busso (2009)
J. Immunol. 183, 4003-4012
 |  Abstract »  |  Full Text »  |  PDF »

Role of ASC in the Mouse Model of Helicobacter pylori Infection.

B. N. Benoit, M. Kobayashi, M. Kawakubo, M. Takeoka, K. Sano, J. Zou, N. Itano, H. Tsutsui, T. Noda, M. Fukuda, et al. (2009)
J. Histochem. Cytochem. 57, 327-338
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes.

M. Lamkanfi, T.-D. Kanneganti, P. Van Damme, T. Vanden Berghe, I. Vanoverberghe, J. Vandekerckhove, P. Vandenabeele, K. Gevaert, and G. Nunez (2008)
Mol. Cell. Proteomics 7, 2350-2363
 |  Abstract »  |  Full Text »  |  PDF »

Inflammasomes and rheumatic diseases: evolving concepts.

P I Sidiropoulos, G Goulielmos, G K Voloudakis, E Petraki, and D T Boumpas (2008)
Ann Rheum Dis 67, 1382-1389
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Invariant Chain Processing, Antigen-Induced Proliferative Responses, and the Development of Collagen-Induced Arthritis and Experimental Autoimmune Encephalomyelitis by a Small Molecule Cysteine Protease Inhibitor.

P. L. Podolin, B. J. Bolognese, D. C. Carpenter, T. G. Davis, R. A. Johanson, J. H. Fox, E. Long III, X. Dong, R. W. Marquis, S. M. LoCastro, et al. (2008)
J. Immunol. 180, 7989-8003
 |  Abstract »  |  Full Text »  |  PDF »

Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2.

N. Marina-Garcia, L. Franchi, Y.-G. Kim, D. Miller, C. McDonald, G.-J. Boons, and G. Nunez (2008)
J. Immunol. 180, 4050-4057
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion.

G. N. Schroeder and H. Hilbi (2008)
Clin. Microbiol. Rev. 21, 134-156
 |  Abstract »  |  Full Text »  |  PDF »

NLR proteins: integral members of innate immunity and mediators of inflammatory diseases.

J. M. Wilmanski, T. Petnicki-Ocwieja, and K. S. Kobayashi (2008)
J. Leukoc. Biol. 83, 13-30
 |  Abstract »  |  Full Text »  |  PDF »

Inflammasome-Mediated Production of IL-1beta Is Required for Neutrophil Recruitment against Staphylococcus aureus In Vivo.

L. S. Miller, E. M. Pietras, L. H. Uricchio, K. Hirano, S. Rao, H. Lin, R. M. O'Connell, Y. Iwakura, A. L. Cheung, G. Cheng, et al. (2007)
J. Immunol. 179, 6933-6942
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Role for Defensins in Intestinal Homeostasis: Regulation of IL-1beta Secretion.

J. Shi, S. Aono, W. Lu, A. J. Ouellette, X. Hu, Y. Ji, L. Wang, S. Lenz, F. W. van Ginkel, M. Liles, et al. (2007)
J. Immunol. 179, 1245-1253
 |  Abstract »  |  Full Text »  |  PDF »

Pyrin Levels in Human Monocytes and Monocyte-Derived Macrophages Regulate IL-1beta Processing and Release.

S. Seshadri, M. D. Duncan, J. M. Hart, M. A. Gavrilin, and M. D. Wewers (2007)
J. Immunol. 179, 1274-1281
 |  Abstract »  |  Full Text »  |  PDF »

Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria.

L. Franchi, T.-D. Kanneganti, G. R. Dubyak, and G. Nunez (2007)
J. Biol. Chem. 282, 18810-18818
 |  Abstract »  |  Full Text »  |  PDF »

Cloning IL-1 and the Birth of a New Era in Cytokine Biology.

T. T. Pizarro and F. Cominelli (2007)
J. Immunol. 178, 5411-5412
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Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA.

T.-D. Kanneganti, M. Body-Malapel, A. Amer, J.-H. Park, J. Whitfield, L. Franchi, Z. F. Taraporewala, D. Miller, J. T. Patton, N. Inohara, et al. (2006)
J. Biol. Chem. 281, 36560-36568
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-1 Regulates Escherichia coli Sepsis and Splenic B Cell Apoptosis Independently of Interleukin-1beta and Interleukin-18.

A. Sarkar, M. W. Hall, M. Exline, J. Hart, N. Knatz, N. T. Gatson, and M. D. Wewers (2006)
Am. J. Respir. Crit. Care Med. 174, 1003-1010
 |  Abstract »  |  Full Text »  |  PDF »

The Inflammatory Caspases: Key Players in the Host Response to Pathogenic Invasion and Sepsis.

A. Nadiri, M. K. Wolinski, and M. Saleh (2006)
J. Immunol. 177, 4239-4245
 |  Abstract »  |  Full Text »  |  PDF »

MaxiK Blockade Selectively Inhibits the Lipopolysaccharide-Induced I{kappa}B-{alpha}/NF-{kappa}B Signaling Pathway in Macrophages.

M. Papavlassopoulos, C. Stamme, L. Thon, D. Adam, D. Hillemann, U. Seydel, and A. B. Schromm (2006)
J. Immunol. 177, 4086-4093
 |  Abstract »  |  Full Text »  |  PDF »

Physiological Functions of Caspases Beyond Cell Death.

T. Q. Nhan, W. C. Liles, and S. M. Schwartz (2006)
Am. J. Pathol. 169, 729-737
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Haplotypes of the Caspase-1 Gene, Plasma Caspase-1 Levels, and Cardiovascular Risk.

S. Blankenberg, T. Godefroy, O. Poirier, H. J. Rupprecht, S. Barbaux, C. Bickel, V. Nicaud, R. Schnabel, F. Kee, C. Morrison, et al. (2006)
Circ. Res. 99, 102-108
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of caspase-1 in rat brain reduces spontaneous nonrapid eye movement sleep and nonrapid eye movement sleep enhancement induced by lipopolysaccharide.

L. Imeri, S. Bianchi, and M. R. Opp (2006)
Am J Physiol Regulatory Integrative Comp Physiol 291, R197-R204
 |  Abstract »  |  Full Text »  |  PDF »

The NS5A Protein of the Hepatitis C Virus Genotype 1a Is Cleaved by Caspases to Produce C-terminal-truncated Forms of the Protein That Reside Mainly in the Cytosol.

M. Kalamvoki, U. Georgopoulou, and P. Mavromara (2006)
J. Biol. Chem. 281, 13449-13462
 |  Abstract »  |  Full Text »  |  PDF »

Tissue Kallikrein mK13 Is a Candidate Processing Enzyme for the Precursor of Interleukin-1beta in the Submandibular Gland of Mice.

C. Yao, M. R. Karabasil, N. Purwanti, X. Li, T. Akamatsu, N. Kanamori, and K. Hosoi (2006)
J. Biol. Chem. 281, 7968-7976
 |  Abstract »  |  Full Text »  |  PDF »

Inflammation-activated Protein Kinases as Targets for Drug Development.

M. Karin (2005)
Proceedings of the ATS 2, 386-390
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of Dimethyl Sulfoxide Augmentation of IL-1{beta} Production.

L. Xing and D. G. Remick (2005)
J. Immunol. 174, 6195-6202
 |  Abstract »  |  Full Text »  |  PDF »

NF-{kappa}B- and C/EBP{beta}-driven Interleukin-1{beta} Gene Expression and PAK1-mediated Caspase-1 Activation Play Essential Roles in Interleukin-1{beta} Release from Helicobacter pylori Lipopolysaccharide-stimulated Macrophages.

C. Basak, S. K. Pathak, A. Bhattacharyya, D. Mandal, S. Pathak, and M. Kundu (2005)
J. Biol. Chem. 280, 4279-4288
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Profiling Reveals Complex Regulation of the Monocyte IL-1{beta} System by IL-13.

C. J. Scotton, F. O. Martinez, M. J. Smelt, M. Sironi, M. Locati, A. Mantovani, and S. Sozzani (2005)
J. Immunol. 174, 834-845
 |  Abstract »  |  Full Text »  |  PDF »

INCA, a Novel Human Caspase Recruitment Domain Protein That Inhibits Interleukin-1{beta} Generation.

M. Lamkanfi, G. Denecker, M. Kalai, K. D'hondt, A. Meeus, W. Declercq, X. Saelens, and P. Vandenabeele (2004)
J. Biol. Chem. 279, 51729-51738
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen activated protein kinases as targets for development of novel anti-inflammatory drugs.

M Karin (2004)
Ann Rheum Dis 63, ii62-ii64
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of IL-8 and IL-1{beta} expression in Crohn's disease associated NOD2/CARD15 mutations.

J. Li, T. Moran, E. Swanson, C. Julian, J. Harris, D. K. Bonen, M. Hedl, D. L. Nicolae, C. Abraham, and J. H. Cho (2004)
Hum. Mol. Genet. 13, 1715-1725
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-1 Activates Nuclear Factor of the {kappa}-Enhancer in B Cells Independently of Its Enzymatic Activity.

M. Lamkanfi, M. Kalai, X. Saelens, W. Declercq, and P. Vandenabeele (2004)
J. Biol. Chem. 279, 24785-24793
 |  Abstract »  |  Full Text »  |  PDF »

Anthrax Lethal Toxin Rapidly Activates Caspase-1/ICE and Induces Extracellular Release of Interleukin (IL)-1{beta} and IL-18.

R. Cordoba-Rodriguez, H. Fang, C. S. R. Lankford, and D. M. Frucht (2004)
J. Biol. Chem. 279, 20563-20566
 |  Abstract »  |  Full Text »  |  PDF »

Janus Kinase 3 Down-Regulates Lipopolysaccharide-Induced IL-1{beta}-Converting Enzyme Activation by Autocrine IL-10.

H.-J. Kim, J. Hart, N. Knatz, M. W. Hall, and M. D. Wewers (2004)
J. Immunol. 172, 4948-4955
 |  Abstract »  |  Full Text »  |  PDF »

Glu496 to Ala Polymorphism in the P2X7 Receptor Impairs ATP-Induced IL-1{beta} Release from Human Monocytes.

R. Sluyter, A. N. Shemon, and J. S. Wiley (2004)
J. Immunol. 172, 3399-3405
 |  Abstract »  |  Full Text »  |  PDF »

Dopamine and Glutamate Control Area-Restricted Search Behavior in Caenorhabditis elegans.

T. Hills, P. J. Brockie, and A. V. Maricq (2004)
J. Neurosci. 24, 1217-1225
 |  Abstract »  |  Full Text »  |  PDF »

Fas ligation induces IL-1{beta}-dependent maturation and IL-1{beta}-independent survival of dendritic cells: different roles of ERK and NF-{kappa}B signaling pathways.

Z. Guo, M. Zhang, H. An, W. Chen, S. Liu, J. Guo, Y. Yu, and X. Cao (2003)
Blood 102, 4441-4447
 |  Abstract »  |  Full Text »  |  PDF »

Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection.

D. H. Dockrell, H. M. Marriott, L. R. Prince, V. C. Ridger, P. G. Ince, P. G. Hellewell, and M. K. B. Whyte (2003)
J. Immunol. 171, 5380-5388
 |  Abstract »  |  Full Text »  |  PDF »

Glutathione S-Transferase Omega 1-1 Is a Target of Cytokine Release Inhibitory Drugs and May Be Responsible for Their Effect on Interleukin-1beta Posttranslational Processing.

R. E. Laliberte, D. G. Perregaux, L. R. Hoth, P. J. Rosner, C. K. Jordan, K. M. Peese, James. F. Eggler, M. A. Dombroski, K. F. Geoghegan, and C. A. Gabel (2003)
J. Biol. Chem. 278, 16567-16578
 |  Abstract »  |  Full Text »  |  PDF »

Specific involvement of caspases in the differentiation of monocytes into macrophages.

O. Sordet, C. Rebe, S. Plenchette, Y. Zermati, O. Hermine, W. Vainchenker, C. Garrido, E. Solary, and L. Dubrez-Daloz (2002)
Blood 100, 4446-4453
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis and Cellular Activation in the Pathogenesis of Acute Vascular Rejection.

Z. E. Holzknecht, K. L. Kuypers, T. B. Plummer, J. Williams, M. Bustos, G. J. Gores, G. J. Brunn, and J. L. Platt (2002)
Circ. Res. 91, 1135-1141
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-1-Deficient Mice Have Delayed Neutrophil Apoptosis and a Prolonged Inflammatory Response to Lipopolysaccharide-Induced Acute Lung Injury.

S. J. Rowe, L. Allen, V. C. Ridger, P. G. Hellewell, and M. K. B. Whyte (2002)
J. Immunol. 169, 6401-6407
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-11 Gene Expression in Response to Lipopolysaccharide and Interferon-gamma Requires Nuclear Factor-kappa B and Signal Transducer and Activator of Transcription (STAT) 1.

R. Schauvliege, J. Vanrobaeys, P. Schotte, and R. Beyaert (2002)
J. Biol. Chem. 277, 41624-41630
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide-mediated Reactive Oxygen Species and Signal Transduction in the Regulation of Interleukin-1 Gene Expression.

H.-Y. Hsu and M.-H. Wen (2002)
J. Biol. Chem. 277, 22131-22139
 |  Abstract »  |  Full Text »  |  PDF »

Listeria monocytogenes Infection in Caspase-11-Deficient Mice.

N. J. Mueller, R. A. Wilkinson, and J. A. Fishman (2002)
Infect. Immun. 70, 2657-2664
 |  Abstract »  |  Full Text »  |  PDF »

CARD-8 Protein, a New CARD Family Member That Regulates Caspase-1 Activation and Apoptosis.

M. Razmara, S. M. Srinivasula, L. Wang, J.-L. Poyet, B. J. Geddes, P. S. DiStefano, J. Bertin, and E. S. Alnemri (2002)
J. Biol. Chem. 277, 13952-13958
 |  Abstract »  |  Full Text »  |  PDF »

Antimicrobial Peptides Initiate IL-1{beta} Posttranslational Processing: A Novel Role Beyond Innate Immunity.

D. G. Perregaux, K. Bhavsar, L. Contillo, J. Shi, and C. A. Gabel (2002)
J. Immunol. 168, 3024-3032
 |  Abstract »  |  Full Text »  |  PDF »

Priming of Macrophages with Lipopolysaccharide Potentiates P2X7-mediated Cell Death via a Caspase-1-dependent Mechanism, Independently of Cytokine Production.

R. A. Le Feuvre, D. Brough, Y. Iwakura, K. Takeda, and N. J. Rothwell (2002)
J. Biol. Chem. 277, 3210-3218
 |  Abstract »  |  Full Text »  |  PDF »

Tail regression in Ciona intestinalis (Prochordate) involves a Caspase-dependent apoptosis event associated with ERK activation.

J.-P. Chambon, J. Soule, P. Pomies, P. Fort, A. Sahuquet, D. Alexandre, P.-H. Mangeat, and S. Baghdiguian (2002)
Development 129, 3105-3114
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of a Novel Class of Interleukin-1 Post-Translational Processing Inhibitors.

D. G. Perregaux, P. McNiff, R. Laliberte, N. Hawryluk, H. Peurano, E. Stam, J. Eggler, R. Griffiths, M. A. Dombroski, and C. A. Gabel (2001)
J. Pharmacol. Exp. Ther. 299, 187-197
 |  Abstract »  |  Full Text »  |  PDF »

Gammalinolenic Acid, an Unsaturated Fatty Acid with Anti-Inflammatory Properties, Blocks Amplification of IL-1{{beta}} Production by Human Monocytes.

R. K. Furse, R. G. Rossetti, and R. B. Zurier (2001)
J. Immunol. 167, 490-496
 |  Abstract »  |  Full Text »  |  PDF »

Proteases for Cell Suicide: Functions and Regulation of Caspases.

H. Y. Chang and X. Yang (2000)
Microbiol. Mol. Biol. Rev. 64, 821-846
 |  Abstract »  |  Full Text »  |  PDF »

ATP Acts as an Agonist to Promote Stimulus-Induced Secretion of IL-1{beta} and IL-18 in Human Blood.

D. G. Perregaux, P. McNiff, R. Laliberte, M. Conklyn, and C. A. Gabel (2000)
J. Immunol. 165, 4615-4623
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the ectromelia virus serpin, SPI-2.

S. J. Turner, J. Silke, B. Kenshole, and J. Ruby (2000)
J. Gen. Virol. 81, 2425-2430
 |  Abstract »  |  Full Text »

Interleukin 18 Restores Defective Th1 Immunity to Candida albicans in Caspase 1-Deficient Mice.

A. Mencacci, A. Bacci, E. Cenci, C. Montagnoli, S. Fiorucci, A. Casagrande, R. A. Flavell, F. Bistoni, and L. Romani (2000)
Infect. Immun. 68, 5126-5131
 |  Abstract »  |  Full Text »  |  PDF »

Nitric Oxide Induces Thymocyte Apoptosis Via a Caspase-1-Dependent Mechanism.

X. Zhou, S. A. Gordon, Y.-M. Kim, R. A. Hoffman, Y. Chen, X.-R. Zhang, R. L. Simmons, and H. R. Ford (2000)
J. Immunol. 165, 1252-1258
 |  Abstract »  |  Full Text »  |  PDF »

Lineage commitment in the immune system: the T helper lymphocyte grows up.

L. H. Glimcher and K. M. Murphy (2000)
Genes & Dev. 14, 1693-1711
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Secretion of bioactive interleukin-1beta by dendritic cells is modulated by interaction with antigen specific T cells.

S. Gardella, C. Andrei, S. Costigliolo, L. Olcese, M. R. Zocchi, and A. Rubartelli (2000)
Blood 95, 3809-3815
 |  Abstract »  |  Full Text »  |  PDF »

The Serpin Proteinase Inhibitor 9 Is an Endogenous Inhibitor of Interleukin 1{beta}-Converting Enzyme (Caspase-1) Activity in Human Vascular Smooth Muscle Cells.

J. L. Young, G. K. Sukhova, D. Foster, W. Kisiel, P. Libby, and U. Schonbeck (2000)
J. Exp. Med. 191, 1535-1544
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Initial Characterization of Four Novel Members of the Interleukin-1 Family.

S. Kumar, P. C. McDonnell, R. Lehr, L. Tierney, M. N. Tzimas, D. E. Griswold, E. A. Capper, R. Tal-Singer, G. I. Wells, M. L. Doyle, et al. (2000)
J. Biol. Chem. 275, 10308-10314
 |  Abstract »  |  Full Text »  |  PDF »

Four New Members Expand the Interleukin-1 Superfamily.

D. E. Smith, B. R. Renshaw, R. R. Ketchem, M. Kubin, K. E. Garka, and J. E. Sims (2000)
J. Biol. Chem. 275, 1169-1175
 |  Abstract »  |  Full Text »  |  PDF »

ATP Treatment of Human Monocytes Promotes Caspase-1 Maturation and Externalization.

R. E. Laliberte, J. Eggler, and C. A. Gabel (1999)
J. Biol. Chem. 274, 36944-36951
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-18 acts as an angiogenesis and tumor suppressor.

R. CAO, J. FARNEBO, M. KURIMOTO, and Y. CAO (1999)
FASEB J 13, 2195-2202
 |  Abstract »  |  Full Text »

Mutational Analysis of the Caenorhabditis elegans Cell-Death Gene ced-3.

S. Shaham, P. W. Reddien, B. Davies, and H. R. Horvitz (1999)
Genetics 153, 1655-1671
 |  Abstract »  |  Full Text »

Role of Granulocyte-Macrophage Colony-Stimulating Factor and Its Receptor in the Genesis of Acute Respiratory Distress Syndrome Through an Effect on Neutrophil Apoptosis.

E. R. Goodman, P. Stricker, M. Velavicius, R. Fonseca, E. Kleinstein, R. Lavery, E. A. Deitch, C. J. Hauser, and H. H. Simms (1999)
Arch Surg 134, 1049-1054
 |  Abstract »  |  Full Text »  |  PDF »

Neuronal Interleukin-16 (NIL-16): A Dual Function PDZ Domain Protein.

C. Kurschner and M. Yuzaki (1999)
J. Neurosci. 19, 7770-7780
 |  Abstract »  |  Full Text »  |  PDF »

Cytokines in asthma.

K F Chung and P J Barnes (1999)
Thorax 54, 825-857
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Regulation of Apoptosis in Myeloid Cells by Interferon Consensus Sequence-Binding Protein.

L. Gabriele, J. Phung, J. Fukumoto, D. Segal, I-M. Wang, P. Giannakakou, N. A. Giese, K. Ozato, and H. C. Morse III (1999)
J. Exp. Med. 190, 411-422
 |  Abstract »  |  Full Text »  |  PDF »

Suicidal Tendencies: Apoptotic Cell Death by Caspase Family Proteinases.

B. B. Wolf and D. R. Green (1999)
J. Biol. Chem. 274, 20049-20052
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Role of Caspase in a Subset of Human Platelet Activation Responses.

A. Shcherbina and E. Remold-O'Donnell (1999)
Blood 93, 4222-4231
 |  Abstract »  |  Full Text »  |  PDF »

Frameshift Mutations at Mononucleotide Repeats in caspase-5 and Other Target Genes in Endometrial and Gastrointestinal Cancer of the Microsatellite Mutator Phenotype.

S. Schwartz Jr., H. Yamamoto, M. Navarro, M. Maestro, J. Reventos, and M. Perucho (1999)
Cancer Res. 59, 2995-3002
 |  Abstract »  |  Full Text »  |  PDF »

The Secretory Route of the Leaderless Protein Interleukin 1beta Involves Exocytosis of Endolysosome-related Vesicles.

C. Andrei, C. Dazzi, L. Lotti, M. R. Torrisi, G. Chimini, and A. Rubartelli (1999)
Mol. Biol. Cell 10, 1463-1475
 |  Abstract »  |  Full Text »

Endotoxin-Stimulated Monocytes Release Multiple Forms of IL-1{beta}, Including a ProIL-1{beta} Form Whose Detection Is Affected by Export.

M. D. Wewers2, A. V. Winnard, and H. A. Dare (1999)
J. Immunol. 162, 4858-4863
 |  Abstract »  |  Full Text »  |  PDF »

A cloning method to identify caspases and their regulators in yeast: Identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1.

C. J. Hawkins, S. L. Wang, and B. A. Hay (1999)
PNAS 96, 2885-2890
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Studies Define the Primary Structure of alpha 1-Antichymotrypsin (ACT) Protease Inhibitor in Alzheimer's Disease Brains. COMPARISON OF ACT IN HIPPOCAMPUS AND LIVER.

S.-R. Hwang, B. Steineckert, A. Kohn, M. Palkovits, and V. Y. H. Hook (1999)
J. Biol. Chem. 274, 1821-1827
 |  Abstract »  |  Full Text »  |  PDF »

Direct Interaction between Gingival Fibroblasts and Lymphoid Cells Induces Inflammatory Cytokine mRNA Expression in Gingival Fibroblasts.

S. Murakami, E. Hino, Y. Shimabukuro, T. Nozaki, Y. Kusumoto, T. Saho, F. Hirano, H. Hirano, and H. Okada (1999)
Journal of Dental Research 78, 69-76
 |  Abstract »  |  PDF »

Cytokines - killers in the brain?.

N. J Rothwell (1999)
J. Physiol. 514, 3-17
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Multiple Caenorhabditis elegans Caspases and Their Potential Roles in Proteolytic Cascades.

S. Shaham (1998)
J. Biol. Chem. 273, 35109-35117
 |  Abstract »  |  Full Text »  |  PDF »

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia.

J. Yrjanheikki, R. Keinanen, M. Pellikka, T. Hokfelt, and J. Koistinaho (1998)
PNAS 95, 15769-15774
 |  Abstract »  |  Full Text »  |  PDF »

Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB.

H. Hilbi, J. E. Moss, D. Hersh, Y. Chen, J. Arondel, S. Banerjee, R. A. Flavell, J. Yuan, P. J. Sansonetti, and A. Zychlinsky (1998)
J. Biol. Chem. 273, 32895-32900
 |  Abstract »  |  Full Text »  |  PDF »

Inflammatory Mediators of Asthma: An Update.

P. J. Barnes, K. F. Chung, and C. P. Page (1998)
Pharmacol. Rev. 50, 515-596
 |  Abstract »  |  Full Text »  |  PDF »

Human monocyte stimulus-coupled IL-1beta posttranslational processing: modulation via monovalent cations.

D. G. Perregaux and C. A. Gabel (1998)
Am J Physiol Cell Physiol 275, C1538-C1547
 |  Abstract »  |  Full Text »  |  PDF »

Nitric Oxide Prevents IL-1{beta} and IFN-{gamma}-Inducing Factor (IL-18) Release from Macrophages by Inhibiting Caspase-1 (IL-1{beta}-Converting Enzyme).

Y.-M. Kim, R. V. Talanian, J. Li, and T. R. Billiar (1998)
J. Immunol. 161, 4122-4128
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Regulation of endothelial monocyte-activating polypeptide II release by apoptosis.

U. E. Knies, H. A. Behrensdorf, C. A. Mitchell, U. Deutsch, W. Risau, H. C. A. Drexler, and M. Clauss (1998)
PNAS 95, 12322-12327
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Generation of Biologically Active IL-1{beta} by Matrix Metalloproteinases: A Novel Caspase-1-Independent Pathway of IL-1{beta} Processing.

U. Schonbeck, F. Mach, and P. Libby (1998)
J. Immunol. 161, 3340-3346
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Calcium/Calmodulin-dependent Protein Kinase IV Is Cleaved by Caspase-3 and Calpain in SH-SY5Y Human Neuroblastoma Cells Undergoing Apoptosis.

K. M. McGinnis, M. M. Whitton, M. E. Gnegy, and K. K. W. Wang (1998)
J. Biol. Chem. 273, 19993-20000
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ERICE, a Novel FLICE-activatable Caspase.

E. W. Humke, J. Ni, and V. M. Dixit (1998)
J. Biol. Chem. 273, 15702-15707
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Proteases to die for.

V. Cryns and J. Yuan (1998)
Genes & Dev. 12, 1551-1570
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Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia.

S. Namura, J. Zhu, K. Fink, M. Endres, A. Srinivasan, K. J. Tomaselli, J. Yuan, and M. A. Moskowitz (1998)
J. Neurosci. 18, 3659-3668
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Generation of Constitutively Active Recombinant Caspases-3 and -6 by Rearrangement of Their Subunits.

S. M. Srinivasula, M. Ahmad, M. MacFarlane, Z. Luo, Z. Huang, T. Fernandes-Alnemri, and E. S. Alnemri (1998)
J. Biol. Chem. 273, 10107-10111
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Granzyme Release and Caspase Activation in Activated Human T-Lymphocytes.

J. M. Zapata, R. Takahashi, G. S. Salvesen, and J. C. Reed (1998)
J. Biol. Chem. 273, 6916-6920
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Generation of a Transgenic Mouse with Lung-specific Overexpression of the Human Interleukin-1 Receptor Antagonist Protein.

R. W. Wilmott, J. A. Kitzmiller, M. A. Fiedler, and J. M. Stark (1998)
Am. J. Respir. Cell Mol. Biol. 18, 429-434
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Tumor necrosis factor in the heart.

D. R. Meldrum (1998)
Am J Physiol Regulatory Integrative Comp Physiol 274, R577-R595
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Expression of interleukin 1beta and interleukin 1beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease.

M E McAlindon, C J Hawkey, and Y R Mahida (1998)
Gut 42, 214-219
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Lipopolysaccharide Activates Caspase-1 (Interleukin-1-Converting Enzyme) in Cultured Monocytic and Endothelial Cells.

R. R. Schumann, C. Belka, D. Reuter, N. Lamping, C. J. Kirschning, J. R. Weber, and D. Pfeil (1998)
Blood 91, 577-584
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The Pristionchus HOX gene Ppa-lin-39 inhibits programmed cell death to specify the vulva equivalence group and is not required during vulval induction.

R. Sommer, A Eizinger, K. Lee, B Jungblut, A Bubeck, and I Schlak (1998)
Development 125, 3865-3873
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Respiratory Syncytial Virus Infection of Neonatal Monocytes Stimulates Synthesis of Interferon Regulatory Factor 1 and Interleukin-1beta (IL-1beta )-Converting Enzyme and Secretion of IL-1beta.

R. Takeuchi, H. Tsutsumi, M. Osaki, S. Sone, S. Imai, and S. Chiba (1998)
J. Virol. 72, 837-840
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Intracellular Precursor Interleukin (IL)-1alpha , but Not Mature IL-1alpha , Is Able to Regulate Human Endothelial Cell Migration in Vitro.

G. A. McMahon, S. Garfinkel, I. Prudovsky, X. Hu, and T. Maciag (1997)
J. Biol. Chem. 272, 28202-28205
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FLICE Is Predominantly Expressed as Two Functionally Active Isoforms, Caspase-8/a and Caspase-8/b.

C. Scaffidi, J. P. Medema, P. H. Krammer, and M. E. Peter (1997)
J. Biol. Chem. 272, 26953-26958
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Cross-Resistance of CD95- and Drug-Induced Apoptosis as a Consequence of Deficient Activation of Caspases (ICE/Ced-3 Proteases).

M. Los, I. Herr, C. Friesen, S. Fulda, K. Schulze-Osthoff, and K.-M. Debatin (1997)
Blood 90, 3118-3129
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Biochemical Characteristics of Caspases-3, -6, -7, and -8.

H. R. Stennicke and G. S. Salvesen (1997)
J. Biol. Chem. 272, 25719-25723
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Activation of Caspase-2 in Apoptosis.

H. Li, L. Bergeron, V. Cryns, M. S. Pasternack, H. Zhu, L. Shi, A. Greenberg, and J. Yuan (1997)
J. Biol. Chem. 272, 21010-21017
 |  Abstract »  |  Full Text »  |  PDF »

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