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Science 27 March 1992:
Vol. 255. no. 5052, pp. 1710 - 1712
DOI: 10.1126/science.1553559
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Articles

Science, Vol 255, Issue 5052, 1710-1712
Copyright © 1992 by American Association for the Advancement of Science

articles

Evidence for a computational distinction between proximal and distal neuronal inhibition

ET Vu and FB Krasne

Department of Psychology, University of California, Los Angeles 90024.

Most neurons have inhibitory synapses both "proximally" near the spike-initiating zone and "distally" on dendrites. Although distal inhibition is thought to be an adaptation for selective inhibition of particular dendritic branches, another important distinction exists between proximal and distal inhibition. Proximal inhibition can attenuate excitatory input absolutely so that no amount of excitation causes firing. Distal inhibition, however, inhibits relatively; any amount of it can be overcome by sufficient excitation. These properties are used as predicted in the circuit-mediating crayfish escape behavior. Many neuronal computations require relative inhibition. This could partly account for the ubiquity of distal inhibition.


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