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Science 20 March 1992:
Vol. 255. no. 5051, pp. 1576 - 1578
DOI: 10.1126/science.1347959
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Articles

Science, Vol 255, Issue 5051, 1576-1578
Copyright © 1992 by American Association for the Advancement of Science

articles

LCMV-specific, class II-restricted cytotoxic T cells in beta 2-microglobulin-deficient mice

D Muller, BH Koller, JL Whitton, KE LaPan, KK Brigman, and JA Frelinger

Department of Microbiology and Immunology, University of North Carolina, Chapel Hill 27599.

Intracranial infection of normal mice with lymphocytic choriomeningitis virus (LCMV) causes meningitis and death mediated by CD8+ major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs). beta 2-Microglobulin-deficient mice (beta 2M-/-) do not express functional MHC class I proteins and do not produce significant numbers of CD8+ T cells. When beta 2M-/- mice were infected with LCMV, many died from LCMV disease and produced a specific response to LCMV mediated by CD4+ CTLs that were class II-restricted. In these mice, CD4+ CTLs may compensate for the lack of CD8+ CTLs.


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