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Science 20 March 1992:
Vol. 255. no. 5051, pp. 1573 - 1576
DOI: 10.1126/science.1347958

Articles

Science, Vol 255, Issue 5051, 1573-1576
Copyright © 1992 by American Association for the Advancement of Science


articles

Transcription factor loading on the MMTV promoter: a bimodal mechanism for promoter activation

TK Archer, P Lefebvre, RG Wolford, and GL Hager

Hormone Action and Oncogenesis Section, Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892.

The mouse mammary tumor virus (MMTV) promoter attains a phased array of six nucleosomes when introduced into rodent cells. This architecture excludes nuclear factor 1/CCAAT transcription factor (NF1/CTF) from the promoter before glucocorticoid treatment and hormone-dependent access of nucleolytic agents to promoter DNA. In contrast, when the promoter was transiently introduced into cells, NF1/CTF was bound constitutively and nucleolytic attack was hormone-independent. Thus, induction at this promoter was a bimodal process involving receptor-dependent remodeling of chromatin that allows NF1/CTF loading and direct receptor-mediated recruitment of additional transcription factors.


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   Abstract »    Full Text »    PDF »
Identification of a Novel cis-Element Required for the Constitutive Activity and Osmotic Response of the Rat Aldose Reductase Promoter.
T. Iwata, S. Minucci, M. McGowan, and D. Carper (1997)
J. Biol. Chem. 272, 32500-32506
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of Mammalian Genes in Vivo. A TALE OF TWO TEMPLATES.
C. L. Smith and G. L. Hager (1997)
J. Biol. Chem. 272, 27493-27496
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Steroid receptor induction of gene transcription: A two-step model.
G. Jenster, T. E. Spencer, M. M. Burcin, S. Y. Tsai, M.-J. Tsai, and B. W. O'Malley (1997)
PNAS 94, 7879-7884
   Abstract »    Full Text »    PDF »
Differential Activity of Progesterone and Glucocorticoid Receptors on Mouse Mammary Tumor Virus Templates Differing in Chromatin Structure.
C. L. Smith, H. Htun, R. G. Wolford, and G. L. Hager (1997)
J. Biol. Chem. 272, 14227-14235
   Abstract »    Full Text »    PDF »
Novel Accessory Factor-Binding Site Required for Glucocorticoid Regulation of the {gamma}-Fibrinogen Subunit Gene from Xenopus laevis.
R. N. Woodward, M. Li, and L. J. Holland (1997)
Mol. Endocrinol. 11, 563-576
   Abstract »    Full Text »
Synergism between hypersensitive sites confers long-range gene activation by the beta -globin locus control region.
E. H. Bresnick and L. Tze (1997)
PNAS 94, 4566-4571
   Abstract »    Full Text »    PDF »
Zeste-mediated activation by an enhancer is independent of cooperative DNA binding in vivo.
J. D. Laney and M. D. Biggin (1997)
PNAS 94, 3602-3604
   Abstract »    Full Text »    PDF »
Nucleosome-mediated synergism between transcription factors on the mouse mammary tumor virus promoter.
S. Chavez and M. Beato (1997)
PNAS 94, 2885-2890
   Abstract »    Full Text »    PDF »
Sequence-specific DNA Binding and Transcription Factor Phosphorylation by Ku Autoantigen/DNA-dependent Protein Kinase. PHOSPHORYLATION OF Ser-527 OF THE RAT GLUCOCORTICOID RECEPTOR.
W. Giffin, J. Kwast-Welfeld, D. J. Rodda, G. G. Prefontaine, M. Traykova-Andonova, Y. Zhang, N. L. Weigel, Y. A. Lefebvre, and R. J.G. Hache (1997)
J. Biol. Chem. 272, 5647-5658
   Abstract »    Full Text »    PDF »
Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: a mechanism for lineage determination in myogenesis..
A N Gerber, T R Klesert, D A Bergstrom, and S J Tapscott (1997)
Genes & Dev. 11, 436-450
   Abstract »    PDF »
Contribution of a Nuclear Factor 1Binding Site to the Glucocorticoid Regulation of the Cytosolic Aspartate Aminotransferase Gene Promoter.
M. Garlatti, M. Aggerbeck, J. Bouguet, and R. Barouki (1996)
J. Biol. Chem. 271, 32629-32634
   Abstract »    Full Text »    PDF »
Expression of a 74-kDa Nuclear Factor 1(NF1) Protein Is Induced in Mouse Mammary Gland Involution. INVOLUTION-ENHANCED OCCUPATION OF A TWIN NF1 BINDING ELEMENT IN THE TESTOSTERONE-REPRESSED PROSTATE MESSAGE-2/CLUSTERIN PROMOTER.
E. E.M. Furlong, N. K. Keon, F. D. Thornton, T. Rein, and F. Martin (1996)
J. Biol. Chem. 271, 29688-29697
   Abstract »    Full Text »    PDF »



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