Science 28 February 1992: Vol. 255. no. 5048, pp. 1137 - 1141 DOI: 10.1126/science.1372131

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Articles

Stem cell concepts renew cancer research.

J. E. Dick (2008)
Blood 112, 4793-4807
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The hematopoietic stem cell and its niche: a comparative view.

J. A. Martinez-Agosto, H. K.A. Mikkola, V. Hartenstein, and U. Banerjee (2007)
Genes & Dev. 21, 3044-3060
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HIV-1 infection and pathogenesis in a novel humanized mouse model.

L. Zhang, G. I. Kovalev, and L. Su (2007)
Blood 109, 2978-2981
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Rats produced by interspecies spermatogonial transplantation in mice and in vitro microinsemination.

T. Shinohara, M. Kato, M. Takehashi, J. Lee, S. Chuma, N. Nakatsuji, M. Kanatsu-Shinohara, and M. Hirabayashi (2006)
PNAS 103, 13624-13628
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Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation.

P. Lan, N. Tonomura, A. Shimizu, S. Wang, and Y.-G. Yang (2006)
Blood 108, 487-492
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The Essential Roles of SDF-1/CXCR4 Interactions in Migration and Development of Normal and Leukemic Human Stem Cells, in Chimeric NOD/SCID mice.

T. Lapidot (2006)
Am. Assoc. Cancer Res. Educ. Book 2006, 3-6
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Experimental Models to Study Development and Function of the Human Immune System In Vivo.

N. Legrand, K. Weijer, and H. Spits (2006)
J. Immunol. 176, 2053-2058
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How do stem cells find their way home?.

T. Lapidot, A. Dar, and O. Kollet (2005)
Blood 106, 1901-1910
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Human Lymphoid and Myeloid Cell Development in NOD/LtSz-scid IL2R{gamma}null Mice Engrafted with Mobilized Human Hemopoietic Stem Cells.

L. D. Shultz, B. L. Lyons, L. M. Burzenski, B. Gott, X. Chen, S. Chaleff, M. Kotb, S. D. Gillies, M. King, J. Mangada, et al. (2005)
J. Immunol. 174, 6477-6489
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Clonal evidence for the transduction of CD34+ cells with lymphomyeloid differentiation potential and self-renewal capacity in the SCID-X1 gene therapy trial.

M. Schmidt, S. Hacein-Bey-Abina, M. Wissler, F. Carlier, A. Lim, C. Prinz, H. Glimm, I. Andre-Schmutz, C. Hue, A. Garrigue, et al. (2005)
Blood 105, 2699-2706
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Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- {gamma}c-/- mice: functional inactivation of p53 in developing T cells.

R. Gimeno, K. Weijer, A. Voordouw, C. H. Uittenbogaart, N. Legrand, N. L. Alves, E. Wijnands, B. Blom, and H. Spits (2004)
Blood 104, 3886-3893
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Expression and regulation of NFAT (nuclear factors of activated T cells) in human CD34+ cells: down-regulation upon myeloid differentiation.

A. Kiani, I. Habermann, M. Haase, S. Feldmann, S. Boxberger, M. A. Sanchez-Fernandez, C. Thiede, M. Bornhauser, and G. Ehninger (2004)
J. Leukoc. Biol. 76, 1057-1065
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CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow.

A. Avigdor, P. Goichberg, S. Shivtiel, A. Dar, A. Peled, S. Samira, O. Kollet, R. Hershkoviz, R. Alon, I. Hardan, et al. (2004)
Blood 103, 2981-2989
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Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment.

F. Mazurier, O. I. Gan, J. L. McKenzie, M. Doedens, and J. E. Dick (2004)
Blood 103, 545-552
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Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/{gamma}cnull mice model.

H. Hiramatsu, R. Nishikomori, T. Heike, M. Ito, K. Kobayashi, K. Katamura, and T. Nakahata (2003)
Blood 102, 873-880
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Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood?.

S. S. Grewal, J. N. Barker, S. M. Davies, and J. E. Wagner (2003)
Blood 101, 4233-4244
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Changes in the Proliferative Activity of Human Hematopoietic Stem Cells in NOD/SCID Mice and Enhancement of Their Transplantability after In Vivo Treatment with Cell Cycle Inhibitors.

J. Cashman, B. Dykstra, I. Clark-Lewis, A. Eaves, and C. Eaves (2002)
J. Exp. Med. 196, 1141-1150
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The in vivo development of human T cells from CD34+ cells in the murine thymic environment.

Y. Saito, Y. Kametani, K. Hozumi, N. Mochida, K. Ando, M. Ito, T. Nomura, Y. Tokuda, H. Makuuchi, T. Tajima, et al. (2002)
Int. Immunol. 14, 1113-1124
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Both CD34+38+ and CD34+38- Cells Home Specifically to the Bone Marrow of NOD/LtSZ scid/scid Mice but Show Different Kinetics in Expansion.

T. C. C. Kerre, G. De Smet, M. De Smedt, F. Offner, J. De Bosscher, J. Plum, and B. Vandekerckhove (2001)
J. Immunol. 167, 3692-3698
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Status of umbilical cord blood transplantation in the year 2001.

J M Hows (2001)
J. Clin. Pathol. 54, 428-434
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Rapid and efficient homing of human CD34+CD38{-}/lowCXCR4+ stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2mnull mice.

O. Kollet, A. Spiegel, A. Peled, I. Petit, T. Byk, R. Hershkoviz, E. Guetta, G. Barkai, A. Nagler, and T. Lapidot (2001)
Blood 97, 3283-3291
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Primate Spermatogonial Stem Cells Colonize Mouse Testes.

M. Nagano, J. R. McCarrey, and R. L. Brinster (2001)
Biol Reprod 64, 1409-1416
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Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells.

F. N. Karanu, B. Murdoch, T. Miyabayashi, M. Ohno, M. Koremoto, L. Gallacher, D. Wu, A. Itoh, S. Sakano, and M. Bhatia (2001)
Blood 97, 1960-1967
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Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production.

L. E. Perez, H. M. Rinder, C. Wang, J. B. Tracey, N. Maun, and D. S. Krause (2001)
Blood 97, 1635-1643
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T Lymphocytes Promote the Development of Bone Marrow-Derived APC in the Central Nervous System.

S. Subramanian, D. N. Bourdette, C. Corless, A. A. Vandenbark, H. Offner, and R. E. Jones (2001)
J. Immunol. 166, 370-376
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Acute Myeloid Leukemia.

F. R. Appelbaum, J. M. Rowe, J. Radich, and J. E. Dick (2001)
Hematology 2001, 62-86
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The human hematopoietic stem cell compartment is heterogeneous for CXCR4 expression.

M. Rosu-Myles, L. Gallacher, B. Murdoch, D. A. Hess, M. Keeney, D. Kelvin, L. Dale, S. S. G. Ferguson, D. Wu, F. Fellows, et al. (2000)
PNAS 97, 14626-14631
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Stable in vivo expression of glucose-6-phosphate dehydrogenase (G6PD) and rescue of G6PD deficiency in stem cells by gene transfer.

A. Rovira, M. De Angioletti, O. Camacho-Vanegas, D. Liu, V. Rosti, H. F. Gallardo, R. Notaro, M. Sadelain, and L. Luzzatto (2000)
Blood 96, 4111-4117
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Donor stromal cells from human blood engraft in NOD/SCID mice.

S.-R. Goan, I. Junghahn, M. Wissler, M. Becker, J. Aumann, U. Just, G. Martiny-Baron, I. Fichtner, and R. Henschler (2000)
Blood 96, 3971-3978
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The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells.

F. N. Karanu, B. Murdoch, L. Gallacher, D. M. Wu, M. Koremoto, S. Sakano, and M. Bhatia (2000)
J. Exp. Med. 192, 1365-1372
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Identification of novel circulating human embryonic blood stem cells.

L. Gallacher, B. Murdoch, D. Wu, F. Karanu, F. Fellows, and M. Bhatia (2000)
Blood 96, 1740-1747
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The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34+ cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice.

A. Peled, O. Kollet, T. Ponomaryov, I. Petit, S. Franitza, V. Grabovsky, M. M. Slav, A. Nagler, O. Lider, R. Alon, et al. (2000)
Blood 95, 3289-3296
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beta 2 Microglobulin-deficient (B2mnull) NOD/SCID mice are excellent recipients for studying human stem cell function.

O. Kollet, A. Peled, T. Byk, H. Ben-Hur, D. Greiner, L. Shultz, and T. Lapidot (2000)
Blood 95, 3102-3105
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NOD/LtSz-Rag1null Mice: An Immunodeficient and Radioresistant Model for Engraftment of Human Hematolymphoid Cells, HIV Infection, and Adoptive Transfer of NOD Mouse Diabetogenic T Cells.

L. D. Shultz, P. A. Lang, S. W. Christianson, B. Gott, B. Lyons, S. Umeda, E. Leiter, R. Hesselton, E. J. Wagar, J. H. Leif, et al. (2000)
J. Immunol. 164, 2496-2507
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice.

B. Schiedlmeier, K. Kuhlcke, H. G. Eckert, C. Baum, W. J. Zeller, and S. Fruehauf (2000)
Blood 95, 1237-1248
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Expansion of human cord blood CD34+CD38- cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: dissociation of SRC phenotype and function.

C. Dorrell, O. I. Gan, D. S. Pereira, R. G. Hawley, and J. E. Dick (2000)
Blood 95, 102-110
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Differentiation Stage-Specific Regulation of Primitive Human Hematopoietic Progenitor Cycling by Exogenous and Endogenous Inhibitors in an In Vivo Model.

J.D. Cashman, I. Clark-Lewis, A.C. Eaves, and C.J. Eaves (1999)
Blood 94, 3722-3729
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Seeding Efficiency of Primitive Human Hematopoietic Cells in Nonobese Diabetic/Severe Combined Immune Deficiency Mice: Implications for Stem Cell Frequency Assessment.

P. B. van Hennik, A. E. de Koning, and R. E. Ploemacher (1999)
Blood 94, 3055-3061
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Unique Differentiation Programs of Human Fetal Liver Stem Cells Shown Both In Vitro and In Vivo in NOD/SCID Mice.

F. E. Nicolini, T. L. Holyoake, J. D. Cashman, P. P.Y. Chu, K. Lambie, and C. J. Eaves (1999)
Blood 94, 2686-2695
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The Soluble Interleukin-6 (IL-6) Receptor/IL-6 Fusion Protein Enhances In Vitro Maintenance and Proliferation of Human CD34+CD38-/low Cells Capable of Repopulating Severe Combined Immunodeficiency Mice.

O. Kollet, R. Aviram, J. Chebath, H. ben-Hur, A. Nagler, L. Shultz, M. Revel, and T. Lapidot (1999)
Blood 94, 923-931
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Engraftment in Nonobese Diabetic Severe Combined Immunodeficient Mice of Human CD34+ Cord Blood Cells After Ex Vivo Expansion: Evidence for the Amplification and Self-Renewal of Repopulating Stem Cells.

W. Piacibello, F. Sanavio, A. Severino, A. Dane, L. Gammaitoni, F. Fagioli, E. Perissinotto, G. Cavalloni, O. Kollet, T. Lapidot, et al. (1999)
Blood 93, 3736-3749
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Identification of Lymphomyeloid Primitive Progenitor Cells in Fresh Human Cord Blood and in the Marrow of Nonobese Diabetic-Severe Combined Immunodeficient (NOD-SCID) Mice Transplanted with Human CD34+ Cord Blood Cells.

C. Robin, F. Pflumio, W. Vainchenker, and L. Coulombel (1999)
J. Exp. Med. 189, 1601-1610
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Bone Morphogenetic Proteins Regulate the Developmental Program of Human Hematopoietic Stem Cells.

M. Bhatia, D. Bonnet, D. Wu, B. Murdoch, J. Wrana, L. Gallacher, and J. E. Dick (1999)
J. Exp. Med. 189, 1139-1148
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Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4.

A. Peled, I. Petit, O. Kollet, M. Magid, T. Ponomaryov, T. Byk, A. Nagler, H. Ben-Hur, A. Many, L. Shultz, et al. (1999)
Science 283, 845-848
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Human Growth Factor-Enhanced Regeneration of Transplantable Human Hematopoietic Stem Cells in Nonobese Diabetic/Severe Combined Immunodeficient Mice.

J. D. Cashman and C. J. Eaves (1999)
Blood 93, 481-487
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High Efficiency Gene Transfer to Human Hematopoietic SCID-Repopulating Cells Under Serum-Free Conditions.

A. J. Schilz, G. Brouns, O. G. Ottmann, D. Hoelzer, A. A. Fauser, A. J. Thrasher, and M. Grez (1998)
Blood 92, 3163-3171
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Cell Cycle-Related Changes in Repopulating Capacity of Human Mobilized Peripheral Blood CD34+ Cells in Non-Obese Diabetic/Severe Combined Immune-Deficient Mice.

A. Gothot, J. C.M. van der Loo, D. W. Clapp, and E. F. Srour (1998)
Blood 92, 2641-2649
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Nonobese Diabetic/Severe Combined Immunodeficiency (NOD/SCID) Mouse as a Model System to Study the Engraftment and Mobilization of Human Peripheral Blood Stem Cells.

J. C.M. van der Loo, H. Hanenberg, R. J. Cooper, F.-Y. Luo, E. N. Lazaridis, and D. A. Williams (1998)
Blood 92, 2556-2570
 |  Abstract »  |  Full Text »  |  PDF »

Treatment of Non-Obese Diabetic (NOD)/Severe-Combined Immunodeficient Mice (SCID) With flt3 Ligand and Interleukin-7 Impairs the B-Lineage Commitment of Repopulating Cells After Transplantation of Human Hematopoietic Cells.

U. Kapp, M. Bhatia, D. Bonnet, B. Murdoch, and J. E. Dick (1998)
Blood 92, 2024-2031
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Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells.

D. S. Pereira, C. Dorrell, C. Y. Ito, O. I. Gan, B. Murdoch, V. N. Rao, J.-P. Zou, E. S. P. Reddy, and J. E. Dick (1998)
PNAS 95, 8239-8244
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Enhanced Megakaryocyte and Erythroid Development From Normal Human CD34+ Cells: Consequence of Enforced Expression of SCL.

N. J. Elwood, H. Zogos, D. S. Pereira, J. E. Dick, and C. G. Begley (1998)
Blood 91, 3756-3765
 |  Abstract »  |  Full Text »  |  PDF »

High Level Engraftment of NOD/SCID Mice by Primitive Normal and Leukemic Hematopoietic Cells From Patients With Chronic Myeloid Leukemia in Chronic Phase.

J.C.Y. Wang, T. Lapidot, J.D. Cashman, M. Doedens, L. Addy, D.R. Sutherland, R. Nayar, P. Laraya, M. Minden, A. Keating, et al. (1998)
Blood 91, 2406-2414
 |  Abstract »  |  Full Text »  |  PDF »

Establishment of a Reproducible Model of Chronic-Phase Chronic Myeloid Leukemia in NOD/SCID Mice Using Blood-Derived Mononuclear or CD34+ Cells.

I. D. Lewis, L. A. McDiarmid, L. M. Samels, L. Bik To, and T. P. Hughes (1998)
Blood 91, 630-640
 |  Abstract »  |  Full Text »  |  PDF »

Long-Term Malignant Hematopoiesis in Human Acute Leukemia Bone Marrow Biopsies Implanted in Severe Combined Immunodeficiency Mice.

F. Legrand, I. Khazaal, M. Peuchmaur, O. Fenneteau, H. Cave, P. Rohrlich, E. Vilmer, and B. Peault (1997)
Blood 90, 2001-2009
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative Analysis Reveals Expansion of Human Hematopoietic Repopulating Cells After Short-term Ex Vivo Culture.

M. Bhatia, D. Bonnet, U. Kapp, J. C.Y. Wang, B. Murdoch, and J. E. Dick (1997)
J. Exp. Med. 186, 619-624
 |  Abstract »  |  Full Text »  |  PDF »

Differential Maintenance of Primitive Human SCID-Repopulating Cells, Clonogenic Progenitors, and Long-Term Culture-Initiating Cells After Incubation on Human Bone Marrow Stromal Cells.

O. I. Gan, B. Murdoch, A. Larochelle, and J. E. Dick (1997)
Blood 90, 641-650
 |  Abstract »  |  Full Text »  |  PDF »

Engraftment and Development of Human CD34+-Enriched Cells From Umbilical Cord Blood in NOD/LtSz-scid/scid Mice.

C. J. Hogan, E. J. Shpall, O. McNulty, I. McNiece, J. E. Dick, L. D. Shultz, and G. Keller (1997)
Blood 90, 85-96
 |  Abstract »  |  Full Text »  |  PDF »

Kinetic Evidence of the Regeneration of Multilineage Hematopoiesis From Primitive Cells in Normal Human Bone Marrow Transplanted Into Immunodeficient Mice.

J. D. Cashman, T. Lapidot, J. C.Y. Wang, M. Doedens, L. D. Shultz, P. Lansdorp, J. E. Dick, and C. J. Eaves (1997)
Blood 89, 4307-4316
 |  Abstract »  |  Full Text »  |  PDF »

Primitive Human Hematopoietic Cells Are Enriched in Cord Blood Compared With Adult Bone Marrow or Mobilized Peripheral Blood as Measured by the Quantitative In Vivo SCID-Repopulating Cell Assay.

J. C.Y. Wang, M. Doedens, and J. E. Dick (1997)
Blood 89, 3919-3924
 |  Abstract »  |  Full Text »  |  PDF »

Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice.

M. Bhatia, J. C. Y. Wang, U. Kapp, D. Bonnet, and J. E. Dick (1997)
PNAS 94, 5320-5325
 |  Abstract »  |  Full Text »  |  PDF »

Lack of Expression of Thy-1 (CD90) on Acute Myeloid Leukemia Cells With Long-Term Proliferative Ability In Vitro and In Vivo.

A. Blair, D.E. Hogge, L.E. Ailles, P.M. Lansdorp, and H.J. Sutherland (1997)
Blood 89, 3104-3112
 |  Abstract »  |  Full Text »  |  PDF »

Severe Combined Immunodeficiency Mice Engrafted With Human T Cells, B Cells, and Myeloid Cells After Transplantation With Human Fetal Bone Marrow or Liver Cells and Implanted With Human Fetal Thymus: A Model for Studying Human Gene Therapy.

S. Yurasov, T. R. Kollmann, A. Kim, C. A. Raker, M. Hachamovitch, F. Wong-Staal, and H. Goldstein (1997)
Blood 89, 1800-1810
 |  Abstract »  |  Full Text »  |  PDF »

ES cells have only a limited lymphopoietic potential after adoptive transfer into mouse recipients.

A. Muller and E. Dzierzak (1993)
Development 118, 1343-1351
 |  Abstract »  |  PDF »

Stem-cell gene therapy moves toward approval.

L Thompson (1992)
Science 255, 1072
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