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Science 28 February 1992:
Vol. 255. no. 5048, pp. 1125 - 1127
DOI: 10.1126/science.1347662

Articles

Science, Vol 255, Issue 5048, 1125-1127
Copyright © 1992 by American Association for the Advancement of Science


articles

Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1

M Isobe, H Yagita, K Okumura, and A Ihara

Cardiac Unit, Massachusetts General Hospital, Boston, 02114.

An indefinite survival of cardiac allografts between fully incompatible mice strains was observed when monoclonal antibodies (MAbs) to intercellular adhesion molecule-1 (ICAM-1) and leukocyte function-associated antigen-1 (LFA-1) were simultaneously administered after the transplantation for 6 days. Mice with long-term surviving cardiac allografts accepted skin grafts from the donor-strain but rejected skin grafts from a third-party strain. Because MAbs to ICAM-1 or LFA-1 alone were insufficient for prolonged tolerance, the two MAbs probably acted synergistically to induce specific unresponsiveness. Thus, ICAM-1----LFA-1 adhesion participates in the induction of allograft rejection and MAbs may be useful as therapeutic agents.


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