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Science 21 February 1992:
Vol. 255. no. 5047, pp. 989 - 991
DOI: 10.1126/science.1312256

Articles

Science, Vol 255, Issue 5047, 989-991
Copyright © 1992 by American Association for the Advancement of Science


articles

The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

C de Vries, JA Escobedo, H Ueno, K Houck, N Ferrara, and LT Williams

Department of Medicine, University of California, San Francisco 94143.

The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt complementary DNA in COS cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular permeability factor (VEGF-VPF), a factor that induces vascular permeability when injected in the guinea pig skin and stimulates endothelial cell proliferation. Expression of Flt in Xenopus laevis oocytes caused the oocytes to release calcium in response to VEGF-VPF. These findings show that flt encodes a receptor for VEGF-VPF.


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Biol Reprod 69, 1388-1393
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Viral Vascular Endothelial Growth Factors Vary Extensively in Amino Acid Sequence, Receptor-binding Specificities, and the Ability to Induce Vascular Permeability yet Are Uniformly Active Mitogens.
L. M. Wise, N. Ueda, N. H. Dryden, S. B. Fleming, C. Caesar, S. Roufail, M. G. Achen, S. A. Stacker, and A. A. Mercer (2003)
J. Biol. Chem. 278, 38004-38014
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Vascular Endothelial Growth Factor Regulates Focal Adhesion Assembly in Human Brain Microvascular Endothelial Cells through Activation of the Focal Adhesion Kinase and Related Adhesion Focal Tyrosine Kinase.
H. K. Avraham, T.-H. Lee, Y. Koh, T.-A. Kim, S. Jiang, M. Sussman, A. M. Samarel, and S. Avraham (2003)
J. Biol. Chem. 278, 36661-36668
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Structure and Inhibitory Effects on Angiogenesis and Tumor Development of a New Vascular Endothelial Growth Inhibitor.
L. Zilberberg, S. Shinkaruk, O. Lequin, B. Rousseau, M. Hagedorn, F. Costa, D. Caronzolo, M. Balke, X. Canron, O. Convert, et al. (2003)
J. Biol. Chem. 278, 35564-35573
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Retinal Angiogenesis Is Mediated by an Interaction between the Angiotensin Type 2 Receptor, VEGF, and Angiopoietin.
S. Sarlos, B. Rizkalla, C. J. Moravski, Z. Cao, M. E. Cooper, and J. L. Wilkinson-Berka (2003)
Am. J. Pathol. 163, 879-887
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Taurine Supplementation of a Low Protein Diet Fed to Rat Dams Normalizes the Vascularization of the Fetal Endocrine Pancreas.
S. Boujendar, E. Arany, D. Hill, C. Remacle, and B. Reusens (2003)
J. Nutr. 133, 2820-2825
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Vascular endothelial growth factor receptor-1 is deposited in the extracellular matrix by endothelial cells and is a ligand for the {alpha}5{beta}1 integrin.
A. Orecchia, P. M. Lacal, C. Schietroma, V. Morea, G. Zambruno, and C. M. Failla (2003)
J. Cell Sci. 116, 3479-3489
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Placenta growth factor activates monocytes and correlates with sickle cell disease severity.
N. Perelman, S. K. Selvaraj, S. Batra, L. R. Luck, A. Erdreich-Epstein, T. D. Coates, V. K. Kalra, and P. Malik (2003)
Blood 102, 1506-1514
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Imaging gastrointestinal tumours using vascular endothelial growth factor-165 (VEGF165) receptor scintigraphy.
S. Li, M. Peck-Radosavljevic, O. Kienast, J. Preitfellner, G. Hamilton, A. Kurtaran, C. Pirich, P. Angelberger, and R. Dudczak (2003)
Ann. Onc. 14, 1274-1277
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Leptomeningeal dissemination at diagnosis of pediatric low-grade neuroepithelial tumors.
J. Hukin, J. Siffert, H. Cohen, L. Velasquez, D. Zagzag, and J. Allen (2003)
Neuro-oncol 5, 188-196
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Modulation of placental vascular endothelial growth factor by leptin and hCG.
D. Islami, P. Bischof, and D. Chardonnens (2003)
Mol. Hum. Reprod. 9, 395-398
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Intravenous Delivery of Adenovirus-mediated Soluble FLT-1 Results in Liver Toxicity.
P. J. Mahasreshti, M. Kataram, M. H. Wang, C. R. Stockard, W. E. Grizzle, D. Carey, G. P. Siegal, H. J. Haisma, R. D. Alvarez, and D. T. Curiel (2003)
Clin. Cancer Res. 9, 2701-2710
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Vascular Endothelial Growth Factor-dependent Down-regulation of Flk-1/KDR Involves Cbl-mediated Ubiquitination: CONSEQUENCES ON NITRIC OXIDE PRODUCTION FROM ENDOTHELIAL CELLS.
M. Duval, S. Bedard-Goulet, C. Delisle, and J.-P. Gratton (2003)
J. Biol. Chem. 278, 20091-20097
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A Set of Loop-1 and -3 Structures in the Novel Vascular Endothelial Growth Factor (VEGF) Family Member, VEGF-ENZ-7, Is Essential for the Activation of VEGFR-2 Signaling.
A. Kiba, N. Yabana, and M. Shibuya (2003)
J. Biol. Chem. 278, 13453-13461
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Angiogenesis: basic pathophysiology and implications for disease.
D.C Felmeden, A.D Blann, and G.Y.H Lip (2003)
Eur. Heart J. 24, 586-603
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Role for Extracellular Signal-Responsive Kinase-1 and -2 in Retinal Angiogenesis.
L. E. Bullard, X. Qi, and J. S. Penn (2003)
Invest. Ophthalmol. Vis. Sci. 44, 1722-1731
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VEGF regulates the proliferation of acid-exposed alveolar lining epithelial cells.
A Ohwada, Y Yoshioka, K Iwabuchi, I Nagaoka, T Dambara, and Y Fukuchi (2003)
Thorax 58, 328-332
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A chemically defined culture of VEGFR2+ cells derived from embryonic stem cells reveals the role of VEGFR1 in tuning the threshold for VEGF in developing endothelial cells.
M. Hirashima, M. Ogawa, S. Nishikawa, K. Matsumura, K. Kawasaki, M. Shibuya, and S.-I. Nishikawa (2003)
Blood 101, 2261-2267
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Expression of Vascular Endothelial Growth Factor and the Effects on Bone Remodeling during Experimental Tooth Movement.
S. Kohno, M. Kaku, K. Tsutsui, M. Motokawa, J. Ohtani, K. Tenjo, Y. Tohma, C. Tokimasa, T. Fujita, T. Kawata, et al. (2003)
Journal of Dental Research 82, 177-182
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