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Science 7 February 1992:
Vol. 255. no. 5045, pp. 721 - 723
DOI: 10.1126/science.1371193
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Articles

Science, Vol 255, Issue 5045, 721-723
Copyright © 1992 by American Association for the Advancement of Science

articles

Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides

HH Schmidt, TD Warner, K Ishii, H Sheng, and F Murad

Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611.

L-arginine causes insulin release from pancreatic B cells. Data from three model systems support the hypothesis that L-arginine-derived nitrogen oxides (NOs) mediate insulin release stimulated by L-arginine in the presence of D-glucose and by the hypoglycemic drug tolbutamide. The formation of NO in pancreatic B cells was detected both chemically and by the NO-induced accumulation of guanosine 3',5'-monophosphate. NG-substituted L-arginine analogs inhibited the release of both insulin and NO. Protein immunoblot and histochemical analysis with antiserum to type I NO synthase suggest that the formation of NO in pancreatic B cells is catalyzed by an NADPH- (reduced form of nicotinamide adenine dinucleotide phosphate), Ca2+/calmodulin-dependent type I NO synthase of about 150 kilodaltons.


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