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Science 24 January 1992:
Vol. 255. no. 5043, pp. 472 - 475
DOI: 10.1126/science.1734526
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Articles

Science, Vol 255, Issue 5043, 472-475
Copyright © 1992 by American Association for the Advancement of Science

articles

Axon guidance by gradients of a target-derived component

H Baier and F Bonhoeffer

Max-Planck-Institut fur Entwicklungsbiologie, Abteilung Physikalische Biologie, Tubingen, Germany.

Spatial gradients of axon guiding molecules have long been suspected to provide positional and directional cues for retinal ganglion cell axons growing within the optic tectum. With the identification of a guiding activity from tectal cell membranes, it has become possible to investigate the potential physiological significance of molecular gradients for retinal growth cone behavior in vitro. A subset of retinal growth cones, those from the temporal half, were highly sensitive to small concentration changes of the guiding component. The degree of response was correlated with the strength of the gradient. These findings demonstrate that the neural growth cone can read gradients of surface-associated information.


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