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Science 17 January 1992:
Vol. 255. no. 5042, pp. 325 - 327
DOI: 10.1126/science.1549777
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Articles

Science, Vol 255, Issue 5042, 325-327
Copyright © 1992 by American Association for the Advancement of Science

articles

Actin-binding protein requirement for cortical stability and efficient locomotion

CC Cunningham, JB Gorlin, DJ Kwiatkowski, JH Hartwig, PA Janmey, HR Byers, and TP Stossel

Divisions of Experimental Medicine, Brigham & Women's Hospital, Boston, MA.

Three unrelated tumor cell lines derived from human malignant melanomas lack actin-binding protein (ABP), which cross-links actin filaments in vitro and connects these filaments to plasma membrane glycoproteins. The ABP-deficient cells have impaired locomotion and display circumferential blebbing of the plasma membrane. Expression of ABP in one of the lines after transfection restored translocational motility and reduced membrane blebbing. These findings establish that ABP functions to stabilize cortical actin in vivo and is required for efficient cell locomotion.


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   Abstract »    Full Text »    PDF »
The actin-myosin cytoskeleton mediates reversible agonist-induced membrane blebbing.
R. Torgerson and M. McNiven (1998)
J. Cell Sci. 111, 2911-2922
   Abstract »    PDF »
Cytoskeletal Protein ABP-280 Directs the Intracellular Trafficking of Furin and Modulates Proprotein Processing in the Endocytic Pathway.
G. Liu, L. Thomas, R. A. Warren, C. A. Enns, C. C. Cunningham, J. H. Hartwig, and G. Thomas (1997)
J. Cell Biol. 139, 1719-1733
   Abstract »    Full Text »    PDF »
Analysis of the Actin-Myosin II System in Fish Epidermal Keratocytes: Mechanism of Cell Body Translocation.
T. M. Svitkina, A. B. Verkhovsky, K. M. McQuade, and G. G. Borisy (1997)
J. Cell Biol. 139, 397-415
   Abstract »    Full Text »    PDF »
Microtubule-associated Protein 2c Reorganizes Both Microtubules and Microfilaments into Distinct Cytological Structures in an Actin-binding Protein-280-deficient Melanoma Cell Line.
C. C. Cunningham, N. Leclerc, L. A. Flanagan, M. Lu, P. A. Janmey, and K. S. Kosik (1997)
J. Cell Biol. 136, 845-857
   Abstract »    Full Text »    PDF »
Actin-biding Protein-280 Binds the Stress-activated Protein Kinase (SAPK) Activator SEK-1 and Is Required for Tumor Necrosis Factor-alpha Activation of SAPK in Melanoma Cells.
A. Marti, Z. Luo, C. Cunningham, Y. Ohta, J. Hartwig, T. P. Stossel, J. M. Kyriakis, and J. Avruch (1997)
J. Biol. Chem. 272, 2620-2628
   Abstract »    Full Text »    PDF »
Identification of the Region in Actin-binding Protein that Binds to the Cytoplasmic Domain of Glycoprotein Ibalpha.
S. C. Meyer, S. Zuerbig, C. C. Cunningham, J. H. Hartwig, T. Bissell, K. Gardner, and J. E.B. Fox (1997)
J. Biol. Chem. 272, 2914-2919
   Abstract »    Full Text »    PDF »
Renal Epithelial Protein (Apx) Is an Actin Cytoskeleton-regulated Na+ Channel.
A. G. Prat, E. J. Holtzman, D. Brown, C. C. Cunningham, I. L. Reisin, T. R. Kleyman, M. McLaughlin, G. R. Jackson Jr., J. Lydon, and H. F. Cantiello (1996)
J. Biol. Chem. 271, 18045-18053
   Abstract »    Full Text »    PDF »
The Cytoplasmic Domain of the alpha-Subunit of Glycoprotein (GP) Ib Mediates Attachment of the Entire GP Ib-IX Complex to the Cytoskeleton and Regulates von Willebrand Factor-induced Changes in Cell Morphology.
J. G. Cunningham, S. C. Meyer, and J. E. B. Fox (1996)
J. Biol. Chem. 271, 11581-11587
   Abstract »    Full Text »    PDF »
Identification of a Binding Sequence for the 14-3-3 Protein within the Cytoplasmic Domain of the Adhesion Receptor, Platelet Glycoprotein Ibalpha.
X. Du, J. E. Fox, and S. Pei (1996)
J. Biol. Chem. 271, 7362-7367
   Abstract »    Full Text »    PDF »
The role of the cortical cytoskeleton: F-actin crosslinking proteins protect against osmotic stress, ensure cell size, cell shape and motility, and contribute to phagocytosis and development.
F Rivero, B Koppel, B Peracino, S Bozzaro, F Siegert, C. Weijer, M Schleicher, R Albrecht, and A. Noegel (1996)
J. Cell Sci. 109, 2679-2691
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Interaction of Platelet Glycoprotein V with Glycoprotein Ib-IX Regulates Expression of the Glycoproteins and Binding of von Willebrand Factor to Glycoprotein Ib-IX in Transfected Cells.
S. C. Meyer and J. E. B. Fox (1995)
J. Biol. Chem. 270, 14693-14699
   Abstract »    Full Text »    PDF »
Regulation of Endocytosis, Exocytosis, and Shape by Membrane Tension.
J. Dai and M.P. Sheetz (1995)
Cold Spring Harb Symp Quant Biol 60, 567-571
   Abstract »    PDF »
Modulation of alpha-actinin levels affects cell motility and confers tumorigenicity on 3T3 cells.
U. Gluck and A. Ben-Ze'ev (1994)
J. Cell Sci. 107, 1773-1782
   Abstract »    PDF »
Supramolecular assemblies of the Ascaris suum major sperm protein (MSP) associated with amoeboid cell motility.
K. King, M Stewart, and T. Roberts (1994)
J. Cell Sci. 107, 2941-2949
   Abstract »    PDF »


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