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Science 3 January 1992:
Vol. 255. no. 5040, pp. 87 - 90
DOI: 10.1126/science.1532458
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Articles

Science, Vol 255, Issue 5040, 87-90
Copyright © 1992 by American Association for the Advancement of Science

articles

Interaction between human cyclin A and adenovirus E1A-associated p107 protein

B Faha, ME Ewen, LH Tsai, DM Livingston, and E Harlow

Massachusetts General Hospital Cancer Center, Charlestown 02129.

The products of the adenovirus early region 1A (E1A) gene are potent oncoproteins when tested in standard transformation and immortalization assays. Many of the changes induced by E1A may be due to its interaction with cellular proteins. Four of these cellular proteins are the retinoblastoma protein (pRB), p107, cyclin A, and p33cdk2. The pRB and p107 proteins are structurally related and have several characteristics in common, including that they both bind to the SV40 large T oncoprotein as well as to E1A. Cyclin A and p33cdk2 are thought to function in the control of the cell cycle. They bind to one another, forming a kinase that closely resembles the cell cycle-regulating complexes containing p34cdc2. Cyclin A is now shown to bind to p107 in the absence of E1A. The association of p107 with cyclin A suggests a direct link between cell cycle control and the function of p107.


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Studies on the in Vitro Phosphorylation of HSSB-p34 and -p107 by Cyclin-dependent Kinases. CYCLIN-SUBSTRATE INTERACTIONS DICTATE THE EFFICIENCY OF PHOSPHORYLATION.
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Shared role of the pRB-related p130 and p107 proteins in limb development..
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W Du, M Vidal, J E Xie, and N Dyson (1996)
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Transforming Growth Factor-beta1 Modulates p107 Function in Myeloid Cells.
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Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members..
G Vairo, D M Livingston, and D Ginsberg (1995)
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E2F-4, a new member of the E2F transcription factor family, interacts with p107..
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Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells.
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Binding and suppression of the Myc transcriptional activation domain by p107.
W Gu, K Bhatia, I. Magrath, C. Dang, and R Dalla-Favera (1994)
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Alternative splicing of human cyclin E.
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Growth Suppression by Members of the Retinoblastoma Protein Family.
L. Zhu, G.H. Enders, C.-L. Wu, M.A. Starz, K.H. Moberg, J.A. Lees, N. Dyson, and E. Harlow (1994)
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The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E..
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Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins..
G J Hannon, D Demetrick, and D Beach (1993)
Genes & Dev. 7, 2378-2391
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Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation..
Y Xiong, H Zhang, and D Beach (1993)
Genes & Dev. 7, 1572-1583
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Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein..
L Zhu, S van den Heuvel, K Helin, A Fattaey, M Ewen, D Livingston, N Dyson, and E Harlow (1993)
Genes & Dev. 7, 1111-1125
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Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.
A Koff, M Ohtsuki, K Polyak, J. Roberts, and J Massague (1993)
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Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4.
(1993)
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Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts.
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Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP.
A Sewing, C Burger, S Brusselbach, C Schalk, F. Lucibello, and R Muller (1993)
J. Cell Sci. 104, 545-555
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E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.
Nevins JR (1992)
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Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner..
E Lees, B Faha, V Dulic, S I Reed, and E Harlow (1992)
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Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins.
M. Ewen, B Faha, E Harlow, and D. Livingston (1992)
Science 255, 85-87
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Collective Inhibition of pRB Family Proteins by Phosphorylation in Cells with p16INK4a Loss or Cyclin E Overexpression.
S. Ashizawa, H. Nishizawa, M. Yamada, H. Higashi, T. Kondo, H. Ozawa, A. Kakita, and M. Hatakeyama (2001)
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