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Science 20 December 1991:
Vol. 254. no. 5039, pp. 1782 - 1784
DOI: 10.1126/science.1763328
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Articles

Science, Vol 254, Issue 5039, 1782-1784
Copyright © 1991 by American Association for the Advancement of Science

articles

Maintenance of normoglycemia in diabetic mice by subcutaneous xenografts of encapsulated islets

PE Lacy, OD Hegre, A Gerasimidi-Vazeou, FT Gentile, and KE Dionne

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110.

The goal of islet transplantation in human diabetes is to maintain the islet grafts in the recipients without the use of immunosuppression. One approach is to encapsulate the donor islets in permselective membranes. Hollow fibers fabricated from an acrylic copolymer were used to encapsulate small numbers of rat islets that were immobilized in an alginate hydrogel for transplantation in diabetic mice. The fibers were biocompatible, prevented rejection, and maintained normoglycemia when transplanted intraperitoneally; hyperglycemia returned when the fibers were removed at 60 days. Normoglycemia was also maintained by subcutaneous implants that had an appropriately constructed outer surface on the fibers.


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Cellular Support Systems for Alginate Microcapsules Containing Islets, as Composite Bioartificial Pancreas.
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Ann. N.Y. Acad. Sci. 944, 252-266
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In Situ Electrochemical Oxygen Generation with an Immunoisolation Device.
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Glucose-Stimulated Genes and Prospects of Gene Therapy for Type I Diabetes.
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Tissue engineering.
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Science 260, 920-926
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IMPLANTED ISLET CELLS NORMALIZE BLOOD SUGAR.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)