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Science 20 December 1991:
Vol. 254. no. 5039, pp. 1773 - 1776
DOI: 10.1126/science.1763326
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Articles

Science, Vol 254, Issue 5039, 1773-1776
Copyright © 1991 by American Association for the Advancement of Science

articles

A fungal gene for antibiotic resistance on a dispensable ("B") chromosome

VP Miao, SF Covert, and HD VanEtten

Department of Plant Pathology, Cornell University, Ithaca, NY 14853.

A family of cytochrome P-450 (Pda) genes in the pathogenic fungus Nectria haematococca is responsible for the detoxification of the phytoalexin pisatin, an antimicrobial compound produced by garden pea (Pisum sativum L.). The Pda6 gene was mapped by electrophoretic karyotype analysis to a small meiotically unstable chromosome that is dispensable for normal growth. Such traits are typical of B chromosomes. The strains of Nectria studied here have no sequences that are homologous to the Pda family other than Pda6 and therefore demonstrate that unique, functional genes can be found on B chromosomes. Unstable B chromosomes may be one mechanism for generating pathogenic variation in fungi.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
B Chromosome Polymorphism in Maize Landraces: Adaptive vs. Demographic Hypothesis of Clinal Variation.
V. V. Lia, V. A. Confalonieri, and L. Poggio (2007)
Genetics 177, 895-904
   Abstract »    Full Text »    PDF »
A Conditionally Dispensable Chromosome Controls Host-Specific Pathogenicity in the Fungal Plant Pathogen Alternaria alternata.
R. Hatta, K. Ito, Y. Hosaki, T. Tanaka, A. Tanaka, M. Yamamoto, K. Akimitsu, and T. Tsuge (2002)
Genetics 161, 59-70
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A Genetic Map of Gibberella zeae (Fusarium graminearum).
J. E. Jurgenson, R. L. Bowden, K. A. Zeller, J. F. Leslie, N. J. Alexander, and R. D. Plattner (2002)
Genetics 160, 1451-1460
   Abstract »    Full Text »    PDF »
Meiotic Deletion at the BUF1 Locus of the Fungus Magnaporthe grisea Is Controlled by Interaction With the Homologous Chromosome.
M. L. Farman (2002)
Genetics 160, 137-148
   Abstract »    Full Text »    PDF »
Detoxification of Corn Antimicrobial Compounds as the Basis for Isolating Fusarium verticillioides and Some Other Fusarium Species from Corn.
A. E. Glenn, D. M. Hinton, I. E. Yates, and C. W. Bacon (2001)
Appl. Envir. Microbiol. 67, 2973-2981
   Abstract »    Full Text »    PDF »
Physical Map of a Conditionally Dispensable Chromosome in Nectria haematococca Mating Population VI and Location of Chromosome Breakpoints.
J. Enkerli, H. Reed, A. Briley, G. Bhatt, and S. F. Covert (2000)
Genetics 155, 1083-1094
   Abstract »    Full Text »
The Evolutionary Biology and Population Genetics Underlying Fungal Strain Typing.
J. W. Taylor, D. M. Geiser, A. Burt, and V. Koufopanou (1999)
Clin. Microbiol. Rev. 12, 126-146
   Abstract »    Full Text »    PDF »
High frequency mitotic gene conversion in genetic hybrids of the oomycete Phytophthorasojae.
J. Chamnanpunt, W.-x. Shan, and B. M. Tyler (2001)
PNAS 98, 14530-14535
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)