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Science 13 December 1991: Vol. 254. no. 5038, pp. 1643 - 1647 DOI: 10.1126/science.1840703
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Articles
Science, Vol 254, Issue 5038, 1643-1647
Copyright © 1991 by American Association for the Advancement of Science
A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
P van der Bruggen,
C Traversari,
P Chomez,
C Lurquin,
E De Plaen,
B Van den Eynde,
A Knuth,
and
T Boon
Ludwig Institute for Cancer Research, Brussels, Belgium.
Many human melanoma tumors express antigens that are recognized in vitro by cytolytic T lymphocytes (CTLs) derived from the tumor-bearing patient. A gene was identified that directed the expression of antigen MZ2-E on a human melanoma cell line. This gene shows no similarity to known sequences and belongs to a family of at least three genes. It is expressed by the original melanoma cells, other melanoma cell lines, and by some tumor cells of other histological types. No expression was observed in a panel of normal tissues. Antigen MZ2-E appears to be presented by HLA-A1; anti-MZ2-E CTLs of the original patient recognized two melanoma cell lines of other HLA-A1 patients that expressed the gene. Thus, precisely targeted immunotherapy directed against antigen MZ2-E could be provided to individuals identified by HLA typing and analysis of the RNA of a small tumor sample.
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- S. Laduron, R. Deplus, S. Zhou, O. Kholmanskikh, D. Godelaine, C. De Smet, S. D. Hayward, F. Fuks, T. Boon, and E. De Plaen (2004)
Nucleic Acids Res.
32, 4340-4350
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- HER-2, gp100, and MAGE-1 Are Expressed in Human Glioblastoma and Recognized by Cytotoxic T Cells.
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Cancer Res.
64, 4980-4986
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- DNA Array-Based Gene Profiling in Tumor Immunology.
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Clin. Cancer Res.
10, 4597-4606
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- Intratumoral CD8+ T Lymphocytes as a Prognostic Factor of Survival in Endometrial Carcinoma.
- S. Kondratiev, E. Sabo, E. Yakirevich, O. Lavie, and M. B. Resnick (2004)
Clin. Cancer Res.
10, 4450-4456
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- Simultaneous Cellular and Humoral Immune Response against Mutated p53 in a Patient with Lung Cancer.
- Y. Ichiki, M. Takenoyama, M. Mizukami, T. So, M. Sugaya, M. Yasuda, T. So, T. Hanagiri, K. Sugio, and K. Yasumoto (2004)
J. Immunol.
172, 4844-4850
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- A Cleaved Form of MAGE-A4 Binds to Miz-1 and Induces Apoptosis in Human Cells.
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J. Biol. Chem.
279, 15505-15514
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- Treatment of Melanoma with 5-Fluorouracil or Dacarbazine In Vitro Sensitizes Cells to Antigen-Specific CTL Lysis through Perforin/Granzyme- and Fas-Mediated Pathways.
- S. Yang and F. G. Haluska (2004)
J. Immunol.
172, 4599-4608
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- NY-ESO-1 Expression and Immunogenicity in Malignant and Benign Breast Tumors.
- Y. Sugita, H. Wada, S. Fujita, T. Nakata, S. Sato, Y. Noguchi, A. A. Jungbluth, M. Yamaguchi, Y.-T. Chen, E. Stockert, et al. (2004)
Cancer Res.
64, 2199-2204
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- DAMAGE, a Novel {alpha}-Dystrobrevin-associated MAGE Protein in Dystrophin Complexes.
- D. E. Albrecht and S. C. Froehner (2004)
J. Biol. Chem.
279, 7014-7023
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- Generation and Targeting of Human Tumor-Specific Tc1 and Th1 Cells Transduced with a Lentivirus Containing a Chimeric Immunoglobulin T-Cell Receptor.
- H. Gyobu, T. Tsuji, Y. Suzuki, T. Ohkuri, K. Chamoto, M. Kuroki, H. Miyoshi, Y. Kawarada, H. Katoh, T. Takeshima, et al. (2004)
Cancer Res.
64, 1490-1495
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- CD4+ T Cells Regulate CD8+ T Cell-Mediated Cutaneous Immune Responses by Restricting Effector T Cell Development through a Fas Ligand-Dependent Mechanism.
- A. V. Gorbachev and R. L. Fairchild (2004)
J. Immunol.
172, 2286-2295
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- Identification of HLA-A24-Restricted CTL Epitope from Cancer-Testis Antigen, NY-ESO-1, and Induction of a Specific Antitumor Immune Response.
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Clin. Cancer Res.
10, 890-896
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- Humoral Responses to Peptides Correlate with Overall Survival in Advanced Cancer Patients Vaccinated with Peptides Based on Pre-existing, Peptide-Specific Cellular Responses.
- T. Mine, Y. Sato, M. Noguchi, T. Sasatomi, R. Gouhara, N. Tsuda, S. Tanaka, H. Shomura, K. Katagiri, T. Rikimaru, et al. (2004)
Clin. Cancer Res.
10, 929-937
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- Complete response to donor lymphocyte infusion in multiple myeloma is associated with antibody responses to highly expressed antigens.
- R. Bellucci, C. J. Wu, S. Chiaretti, E. Weller, F. E. Davies, E. P. Alyea, G. Dranoff, K. C. Anderson, N. C. Munshi, and J. Ritz (2004)
Blood
103, 656-663
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- Limited Gene Activation in Tumor and Normal Epithelial Cells Treated with the DNA Methyltransferase Inhibitor 5-Aza-2'-deoxycytidine.
- A. R. Karpf, A. W. Lasek, T. O. Ririe, A. N. Hanks, D. Grossman, and D. A. Jones (2004)
Mol. Pharmacol.
65, 18-27
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- Expression of the MAGE-A4 and NY-ESO-1 Cancer-Testis Antigens in Serous Ovarian Neoplasms.
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Clin. Cancer Res.
9, 6453-6460
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- Proteasomal targeting of a viral oncogene abrogates oncogenic phenotype and enhances immunogenicity.
- J. Tellam, G. Connolly, N. Webb, J. Duraiswamy, and R. Khanna (2003)
Blood
102, 4535-4540
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- Monoclonal Anti-MAGE-3 CTL Responses in Melanoma Patients Displaying Tumor Regression after Vaccination with a Recombinant Canarypox Virus.
- V. Karanikas, C. Lurquin, D. Colau, N. van Baren, C. De Smet, B. Lethe, T. Connerotte, V. Corbiere, M.-A. Demoitie, D. Lienard, et al. (2003)
J. Immunol.
171, 4898-4904
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- Natural T Cell Immunity against Cancer.
- D. Nagorsen, C. Scheibenbogen, F. M. Marincola, A. Letsch, and U. Keilholz (2003)
Clin. Cancer Res.
9, 4296-4303
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- Cooperative Effect between Immunotherapy and Antiangiogenic Therapy Leads to Effective Tumor Rejection in Tolerant Her-2/neu Mice.
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Cancer Res.
63, 5895-5901
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- NY-ESO-1 and LAGE-1 Cancer-Testis Antigens Are Potential Targets for Immunotherapy in Epithelial Ovarian Cancer.
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Cancer Res.
63, 6076-6083
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- The Receptor Tyrosine Kinase Ror2 Associates with the Melanoma-associated Antigen (MAGE) Family Protein Dlxin-1 and Regulates Its Intracellular Distribution.
- T. Matsuda, H. Suzuki, I. Oishi, S. Kani, Y. Kuroda, T. Komori, A. Sasaki, K. Watanabe, and Y. Minami (2003)
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- Successful elimination of large established tumors and avoidance of antigen-loss variants by aggressive adoptive T cell immunotherapy.
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Int. Immunol.
15, 797-805
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- A novel tumor-vaccine cell therapy using bone marrow-derived dendritic cell type 1 and antigen-specific Th1 cells.
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Int. Immunol.
15, 837-843
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