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Science 15 November 1991:
Vol. 254. no. 5034, pp. 1010 - 1013
DOI: 10.1126/science.1658938
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Articles
Science, Vol 254, Issue 5034, 1010-1013
Copyright © 1991 by American Association for the Advancement of Science
Induction of type I diabetes by Kilham's rat virus in diabetes-resistant BB/Wor rats
DL Guberski,
VA Thomas,
WR Shek,
AA Like,
ES Handler,
AA Rossini,
JE Wallace,
and
RM Welsh
Department of Pathology, University of Massachusetts Medical Center, Worcester 01655.
Type I diabetes mellitus is an autoimmune disease resulting from the interaction of genetic and environmental factors. A virus that was identified serologically as Kilham's rat virus (KRV) was isolated from a spontaneously diabetic rat and reproducibly induced diabetes in naive diabetes-resistant (DR) BB/Wor rats. Viral antigen was not identified in pancreatic islet cells, and beta cell cytolysis was not observed until after the appearance of lymphocytic insulitis. KRV did not induce diabetes in major histocompatibility complex-concordant and discordant non-BB rats and did not accelerate diabetes in diabetes-prone BB/Wor rats unless the rats had been reconstituted with DR spleen cells. This model of diabetes may provide insight regarding the interaction of viruses and autoimmune disease [corrected]
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