Science 25 October 1991: Vol. 254. no. 5031, pp. 573 - 576 DOI: 10.1126/science.1948033

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Articles

Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes.

M. Saberi, D. Bjelica, S. Schenk, T. Imamura, G. Bandyopadhyay, P. Li, V. Jadhar, C. Vargeese, W. Wang, K. Bowman, et al. (2009)
Am J Physiol Endocrinol Metab 297, E1137-E1146
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of net hepatic glycogenolysis and gluconeogenesis by epinephrine in humans.

S. Dufour, V. Lebon, G. I. Shulman, and K. F. Petersen (2009)
Am J Physiol Endocrinol Metab 297, E231-E235
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Evidence That Processes Other Than Gluconeogenesis May Influence the Ratio of Deuterium on the Fifth and Third Carbons of Glucose: Implications for the Use of 2H2O to Measure Gluconeogenesis in Humans.

G. Bock, W. C. Schumann, R. Basu, S. C. Burgess, Z. Yan, V. Chandramouli, R. A. Rizza, and B. R. Landau (2008)
Diabetes 57, 50-55
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Effects of fasting on insulin action and glucose kinetics in lean and obese men and women.

B. C. Bergman, M.-A. Cornier, T. J. Horton, and D. H. Bessesen (2007)
Am J Physiol Endocrinol Metab 293, E1103-E1111
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Hepatic autoregulation: response of glucose production and gluconeogenesis to increased glycogenolysis.

P. Staehr, O. Hother-Nielsen, H. Beck-Nielsen, M. Roden, H. Stingl, J. J. Holst, P. K. Jones, V. Chandramouli, and B. R. Landau (2007)
Am J Physiol Endocrinol Metab 292, E1265-E1269
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Impact of portal glucose delivery on glucose metabolism in conscious, unrestrained mice.

F.-Y. Chueh, C. Malabanan, and O. P. McGuinness (2006)
Am J Physiol Endocrinol Metab 291, E1206-E1211
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Noninvasive analysis of hepatic glycogen kinetics before and after breakfast with deuterated water and acetaminophen..

J. G. Jones, A. Fagulha, C. Barosa, M. Bastos, L. Barros, C. Baptista, M. M. Caldeira, and M. Carvalheiro (2006)
Diabetes 55, 2294-2300
 |  Abstract »  |  Full Text »  |  PDF »

The Goldilocks Paradigm of Starvation and Refeeding.

J. A. Palesty and S. J. Dudrick (2006)
Nutr Clin Pract 21, 147-154
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Role of Hepatic Glycogen Breakdown in Defective Counterregulation of Hypoglycemia in Intensively Treated Type 1 Diabetes.

P. Kishore, I. Gabriely, M.-H. Cui, J. Di Vito, S. Gajavelli, J.-H. Hwang, and H. Shamoon (2006)
Diabetes 55, 659-666
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Partial 13C isotopic enrichment of nucleoside monophosphates: useful reporters for NMR structural studies.

A. I. Kishore, M. R. Mayer, and J. H. Prestegard (2005)
Nucleic Acids Res. 33, e164
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Normal Fasting Plasma Glucose Levels and Type 2 Diabetes in Young Men.

A. Tirosh, I. Shai, D. Tekes-Manova, E. Israeli, D. Pereg, T. Shochat, I. Kochba, A. Rudich, and the Israeli Diabetes Research Group (2005)
N. Engl. J. Med. 353, 1454-1462
 |  Abstract »  |  Full Text »  |  PDF »

Endogenous effectors of human liver glycogen phosphorylase modulate effects of indole-site inhibitors.

N. Ercan-Fang, M. R. Taylor, J. L. Treadway, C. B. Levy, P. E. Genereux, E. M. Gibbs, V. L. Rath, Y. Kwon, M. C. Gannon, and F. Q. Nuttall (2005)
Am J Physiol Endocrinol Metab 289, E366-E372
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of a selective serotonin reuptake inhibitor with insulin in the control of hepatic glucose uptake in conscious dogs.

M. C. Moore, C. A. DiCostanzo, D. Dardevet, M. Lautz, B. Farmer, and A. D. Cherrington (2005)
Am J Physiol Endocrinol Metab 288, E556-E563
 |  Abstract »  |  Full Text »  |  PDF »

Alterations in Postprandial Hepatic Glycogen Metabolism in Type 2 Diabetes.

M. Krssak, A. Brehm, E. Bernroider, C. Anderwald, P. Nowotny, C. D. Man, C. Cobelli, G. W. Cline, G. I. Shulman, W. Waldhausl, et al. (2004)
Diabetes 53, 3048-3056
 |  Abstract »  |  Full Text »  |  PDF »

Intensive Insulin Treatment in Critically Ill Trauma Patients Normalizes Glucose by Reducing Endogenous Glucose Production.

A. Thorell, O. Rooyackers, P. Myrenfors, M. Soop, J. Nygren, and O. H. Ljungqvist (2004)
J. Clin. Endocrinol. Metab. 89, 5382-5386
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FFAs are not involved in regulation of gluconeogenesis and glycogenolysis in adults with uncomplicated P. falciparum malaria.

H. van Thien, G. J. Weverling, M. T. Ackermans, N. canh Hung, E. Endert, P. A. Kager, and H. P. Sauerwein (2004)
Am J Physiol Endocrinol Metab 287, E609-E615
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Vagal cooling and concomitant portal norepinephrine infusion do not reduce net hepatic glucose uptake in conscious dogs.

S. Cardin, M. J. Pagliassotti, M. C. Moore, D. S. Edgerton, M. Lautz, B. Farmer, D. W. Neal, and A. D. Cherrington (2004)
Am J Physiol Regulatory Integrative Comp Physiol 287, R742-R748
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Regulation of Net Hepatic Glycogenolysis and Gluconeogenesis during Exercise: Impact of Type 1 Diabetes.

K. F. Petersen, T. B. Price, and R. Bergeron (2004)
J. Clin. Endocrinol. Metab. 89, 4656-4664
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Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion.

M. C. Moore, S. Cardin, D. S. Edgerton, B. Farmer, D. W. Neal, M. Lautz, and A. D. Cherrington (2004)
Am J Physiol Endocrinol Metab 286, E226-E233
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Nonesterified Fatty Acids and Hepatic Glucose Metabolism in the Conscious Dog.

M. C. Moore, S. Satake, M. Lautz, S. A. Soleimanpour, D. W. Neal, M. Smith, and A. D. Cherrington (2004)
Diabetes 53, 32-40
 |  Abstract »  |  Full Text »  |  PDF »

Measurement of Fractional Whole-Body Gluconeogenesis in Humans From Blood Samples Using 2H Nuclear Magnetic Resonance Spectroscopy.

O. Kunert, H. Stingl, E. Rosian, M. Krssak, E. Bernroider, W. Seebacher, K. Zangger, P. Staehr, V. Chandramouli, B.R. Landau, et al. (2003)
Diabetes 52, 2475-2482
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Smoking impairs muscle recovery from exercise.

T. B. Price, S. Krishnan-Sarin, and D. L. Rothman (2003)
Am J Physiol Endocrinol Metab 285, E116-E122
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Measuring gluconeogenesis using a low dose of 2H2O: advantage of isotope fractionation during gas chromatography.

J. Katanik, B. J. McCabe, D. Z. Brunengraber, V. Chandramouli, F. J. Nishiyama, V. E. Anderson, and S. F. Previs (2003)
Am J Physiol Endocrinol Metab 284, E1043-E1048
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Effects of Acute Insulin Excess and Deficiency on Gluconeogenesis and Glycogenolysis in Type 1 Diabetes.

G. Boden, P. Cheung, and C. Homko (2003)
Diabetes 52, 133-137
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Fasting Glucose Is a Risk Factor For Breast Cancer: A Prospective Study.

P. Muti, T. Quattrin, B. J. B. Grant, V. Krogh, A. Micheli, H. J. Schunemann, M. Ram, J. L. Freudenheim, S. Sieri, M. Trevisan, et al. (2002)
Cancer Epidemiol. Biomarkers Prev. 11, 1361-1368
 |  Abstract »  |  Full Text »  |  PDF »

Effects of fasting and glucocorticoids on hepatic gluconeogenesis assessed using two independent methods in vivo.

R. E. Goldstein, L. Rossetti, B. A. J. Palmer, R. Liu, D. Massillon, M. Scott, D. Neal, P. Williams, B. Peeler, and A. D. Cherrington (2002)
Am J Physiol Endocrinol Metab 283, E946-E957
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Reduction of Hepatic Glycogen Synthesis and Breakdown in Patients with Agenesis of the Dorsal Pancreas.

H. Stingl, W. J. Schnedl, M. Krssak, E. Bernroider, M. G. Bischof, T. Lahousen, G. Pacini, and M. Roden (2002)
J. Clin. Endocrinol. Metab. 87, 4678-4685
 |  Abstract »  |  Full Text »  |  PDF »

Measurement of gluconeogenesis in exercising men by mass isotopomer distribution analysis.

J. K. Trimmer, J.-M. Schwarz, G. A. Casazza, M. A. Horning, N. Rodriguez, and G. A. Brooks (2002)
J Appl Physiol 93, 233-241
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FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis.

G. Boden, P. Cheung, T. P. Stein, K. Kresge, and M. Mozzoli (2002)
Am J Physiol Endocrinol Metab 283, E12-E19
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Integrated effects of multiple modulators on human liver glycogen phosphorylase a.

N. Ercan-Fang, M. C. Gannon, V. L. Rath, J. L. Treadway, M. R. Taylor, and F. Q. Nuttall (2002)
Am J Physiol Endocrinol Metab 283, E29-E37
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Influence of prior exercise and liver glycogen content on the sensitivity of the liver to glucagon.

V. M. Bonjorn, M. G. Latour, P. Belanger, and J.-M. Lavoie (2002)
J Appl Physiol 92, 188-194
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Hepatic Glycogen Metabolism in Type 1 Diabetes After Long-Term Near Normoglycemia.

M. G. Bischof, E. Bernroider, M. Krssak, M. Krebs, H. Stingl, P. Nowotny, C. Yu, G. I. Shulman, W. Waldhausl, and M. Roden (2002)
Diabetes 51, 49-54
 |  Abstract »  |  Full Text »  |  PDF »

An integrated 2H and 13C NMR study of gluconeogenesis and TCA cycle flux in humans.

J. G. Jones, M. A. Solomon, S. M. Cole, A. D. Sherry, and C. R. Malloy (2001)
Am J Physiol Endocrinol Metab 281, E848-E856
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Methods for measuring glycogen cycling.

B. R. Landau (2001)
Am J Physiol Endocrinol Metab 281, E413-E419
 |  Abstract »  |  Full Text »  |  PDF »

Stimulating Effects of Low-Dose Fructose on Insulin-Stimulated Hepatic Glycogen Synthesis in Humans.

K. F. Petersen, D. Laurent, C. Yu, G. W. Cline, and G. I. Shulman (2001)
Diabetes 50, 1263-1268
 |  Abstract »  |  Full Text »

The Quantification of Gluconeogenesis in Healthy Men by 2H2O and [2-13C]Glycerol Yields Different Results: Rates of Gluconeogenesis in Healthy Men Measured with 2H2O Are Higher Than Those Measured with [2-13C]Glycerol.

M. T. Ackermans, A. M. Pereira Arias, P. H. Bisschop, E. Endert, H. P. Sauerwein, and J. A. Romijn (2001)
J. Clin. Endocrinol. Metab. 86, 2220-2226
 |  Abstract »  |  Full Text »

Effects of Free Fatty Acids on Gluconeogenesis and Autoregulation of Glucose Production in Type 2 Diabetes.

G. Boden, X. Chen, E. Capulong, and M. Mozzoli (2001)
Diabetes 50, 810-816
 |  Abstract »  |  Full Text »

Whole-body and adipose tissue glucose metabolism in response to short-term fasting in lean and obese women.

J. F Horowitz, S. W Coppack, and S. Klein (2001)
Am. J. Clinical Nutrition 73, 517-522
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Short-Term Improvement of Insulin Treatment and Glycemia on Hepatic Glycogen Metabolism in Type 1 Diabetes.

M. G. Bischof, M. Krssak, M. Krebs, E. Bernroider, H. Stingl, W. Waldhäusl, and M. Roden (2001)
Diabetes 50, 392-398
 |  Abstract »  |  Full Text »

Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus.

G. Boden, X. Chen, and T. P. Stein (2001)
Am J Physiol Endocrinol Metab 280, E23-E30
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Effects of nicotinic acid on fatty acid kinetics, fuel selection, and pathways of glucose production in women.

W. Wang, A. Basinger, R. A. Neese, M. Christiansen, and M. K. Hellerstein (2000)
Am J Physiol Endocrinol Metab 279, E50-E59
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The Effects of Carbohydrate Variation in Isocaloric Diets on Glycogenolysis and Gluconeogenesis in Healthy Men.

P. H. Bisschop, A. M. P. Arias, M. T. Ackermans, E. Endert, H. Pijl, F. Kuipers, A. J. Meijer, H. P. Sauerwein, and J. A. Romijn (2000)
J. Clin. Endocrinol. Metab. 85, 1963-1967
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Effect of carbohydrate ingestion on glycogen resynthesis in human liver and skeletal muscle, measured by 13C MRS.

A. Casey, R. Mann, K. Banister, J. Fox, P. G. Morris, I. A. Macdonald, and P. L. Greenhaff (2000)
Am J Physiol Endocrinol Metab 278, E65-E75
 |  Abstract »  |  Full Text »  |  PDF »

Measurement of gluconeogenesis and mass isotopomer analysis based on [U-13C]glucose.

J. Radziuk and W.-N. P. Lee (1999)
Am J Physiol Endocrinol Metab 277, E199-E207
 |  Abstract »  |  Full Text »  |  PDF »

Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis.

K. F. Petersen, M. Krssak, V. Navarro, V. Chandramouli, R. Hundal, W. C. Schumann, B. R. Landau, and G. I. Shulman (1999)
Am J Physiol Endocrinol Metab 276, E529-E535
 |  Abstract »  |  Full Text »  |  PDF »

The inhibition of gluconeogenesis following alcohol in humans.

S. Q. Siler, R. A. Neese, M. P. Christiansen, and M. K. Hellerstein (1998)
Am J Physiol Endocrinol Metab 275, E897-E907
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Perioperative insulin and glucose infusion maintains normal insulin sensitivity after surgery.

J. O. Nygren, A. Thorell, M. Soop, S. Efendic, K. Brismar, F. Karpe, K. S. Nair, and O. Ljungqvist (1998)
Am J Physiol Endocrinol Metab 275, E140-E148
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo 13C NMR Measurements of Hepatocellular Tricarboxylic Acid Cycle Flux.

B. M. Jucker, J. Y. Lee, and R. G. Shulman (1998)
J. Biol. Chem. 273, 12187-12194
 |  Abstract »  |  Full Text »  |  PDF »

Dexamethasone, OB Gene, and Leptin in Humans: Effect of Exogenous Hyperinsulinemia--Author's Responseb.

J. W. Kolaczynski (1998)
J. Clin. Endocrinol. Metab. 83, 1822
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Human kidney and liver gluconeogenesis: evidence for organ substrate selectivity.

M. Stumvoll, C. Meyer, G. Perriello, M. Kreider, S. Welle, and J. Gerich (1998)
Am J Physiol Endocrinol Metab 274, E817-E826
 |  Abstract »  |  Full Text »  |  PDF »

Limitations in estimating gluconeogenesis and Cori cycling from mass isotopomer distributions using [U-13C6]glucose.

B. R. Landau, J. Wahren, K. Ekberg, S. F. Previs, D. Yang, and H. Brunengraber (1998)
Am J Physiol Endocrinol Metab 274, E954-E961
 |  Abstract »  |  Full Text »  |  PDF »

Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo.

W. H. Martin, D. J. Hoover, S. J. Armento, I. A. Stock, R. K. McPherson, D. E. Danley, R. W. Stevenson, E. J. Barrett, and J. L. Treadway (1998)
PNAS 95, 1776-1781
 |  Abstract »  |  Full Text »  |  PDF »

Gluconeogenesis measured with [U-13C]glucose and mass isotopomer analysis of apoB-100 amino acids in pigs.

L. J. Wykes, F. Jahoor, and P. J. Reeds (1998)
Am J Physiol Endocrinol Metab 274, E365-E376
 |  Abstract »  |  Full Text »  |  PDF »

Effects of aminooxyacetate on glutamate compartmentation and TCA cycle kinetics in rat hearts.

A. D. Sherry, P. Zhao, A. J. Wiethoff, F. M. H. Jeffrey, and C. R. Malloy (1998)
Am J Physiol Heart Circ Physiol 274, H591-H599
 |  Abstract »  |  Full Text »  |  PDF »

Quantifying gluconeogenesis during fasting.

V. Chandramouli, K. Ekberg, W. C. Schumann, S. C. Kalhan, J. Wahren, and B. R. Landau (1997)
Am J Physiol Endocrinol Metab 273, E1209-E1215
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Hepatic Glycogen Content on Hepatic Insulin Action in Humans: Alteration in the Relative Contributions of Glycogenolysis and Gluconeogenesis to Endogenous Glucose Production.

S. Wise, M. Nielsen, and R. Rizza (1997)
J. Clin. Endocrinol. Metab. 82, 1828-1833
 |  Abstract »  |  Full Text »  |  PDF »

[IMAGE]C and [IMAGE]P NMR Investigation of Effect of 6-Aminonicotinamide on Metabolism of RIF-1 Tumor Cells in Vitro.

J. C. Street, U. Mahmood, D. Ballon, A. A. Alfieri, and J. A. Koutcher (1996)
J. Biol. Chem. 271, 4113-4119
 |  Abstract »  |  Full Text »  |  PDF »

Substrate Metabolism in Humans: 1995 A.S.P.E.N. Research Workshop.

S. Klein and J. Miles (1996)
JPEN J Parenter Enteral Nutr 20, 13-19
 |  Abstract »  |  PDF »

Gluconeogenesis and Intrahepatic Triose Phosphate Flux in Response to Fasting or Substrate Loads.

R. A. Neese, J.-M. Schwarz, D. Faix, S. Turner, A. Letscher, D. Vu, and M. K. Hellerstein (1995)
J. Biol. Chem. 270, 14452-14463
 |  Abstract »  |  Full Text »  |  PDF »

Body Composition: Research and Clinical Advances--1993 A.S.P.E.N. Research Workshop.

S. B. Heymsfield and D. Matmews (1994)
JPEN J Parenter Enteral Nutr 18, 91-103
 |  Abstract »  |  PDF »

GLUCONEOGENESIS IS THE MAIN SOURCE OF GLUCOSE DURING FASTING.

(1991)
Journal Watch (General) 1991, 8
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