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Science 11 October 1991:
Vol. 254. no. 5029, pp. 285 - 288
DOI: 10.1126/science.1925584
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Articles

Science, Vol 254, Issue 5029, 285-288
Copyright © 1991 by American Association for the Advancement of Science

articles

Long-term high-titer neutralizing activity induced by octameric synthetic HIV-1 antigen

CY Wang, DJ Looney, ML Li, AM Walfield, J Ye, B Hosein, JP Tam, and F Wong-Staal

United Biomedical, Inc., Lake Success, NY 11042.

A titer for homologous viral neutralization activity (greater than 1:19,683) was observed after a 3.5-year immunization period with an octameric, branching peptide representing the principal neutralizing determinant (PND) of the human immunodeficiency virus-1IIIB envelope protein. Booster immunizations elicited persistent and potent antibodies in guinea pigs, exceeding responses produced by a conventional bovine serum albumin conjugate by 100-fold. Peptide length, central presentation of a conserved sequence, and inclusion of an upstream sequence contributed to immunogenicity. Titers (greater than 1:1,000) of heterotypic neutralizing antibodies also developed. Octameric PND peptides are a promising approach for an acquired immunodeficiency syndrome (AIDS) vaccine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Y. Nishiyama, Y. Mitsuda, H. Taguchi, S. Planque, M. Salas, C. V. Hanson, and S. Paul (2007)
J. Biol. Chem. 282, 31250-31256
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Identification of B- and T-Cell Epitopes within the Fibronectin-Binding Domain of the SfbI Protein of Streptococcus pyogenes.
K. Schulze, E. Medina, G. S. Chhatwal, and C. A. Guzman (2003)
Infect. Immun. 71, 7197-7201
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Induction of anti-simian immunodeficiency virus cellular and humoral immune responses in rhesus macaques by peptide immunogens: correlation of CTL activity and reduction of cell-associated but not plasma virus load following challenge.
T. U. Vogel, B. E. Beer, J. zur Megede, H.-G. Ihlenfeldt, G. Jung, S. Holzammer, D. I. Watkins, J. D. Altman, R. Kurth, and S. Norley (2002)
J. Gen. Virol. 83, 81-91
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Characterization of V3 Loop-Pseudomonas Exotoxin Chimeras. CANDIDATE VACCINES FOR HUMAN IMMUNODEFICIENCY VIRUS-1.
D. J. FitzGerald, C. M. Fryling, M. L. McKee, J. C. Vennari, T. Wrin, M. E. M. Cromwell, A. L. Daugherty, and R. J. Mrsny (1998)
J. Biol. Chem. 273, 9951-9958
   Abstract »    Full Text »    PDF »
Human Rhinovirus Type 14:Human Immunodeficiency Virus Type 1 (HIV-1) V3 Loop Chimeras from a Combinatorial Library Induce Potent Neutralizing Antibody Responses against HIV-1.
A. D. Smith, S. C. Geisler, A. A. Chen, D. A. Resnick, B. M. Roy, P. J. Lewi, E. Arnold, and G. F. Arnold (1998)
J. Virol. 72, 651-659
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)