Science 11 October 1991: Vol. 254. no. 5029, pp. 274 - 277 DOI: 10.1126/science.1833819

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Articles

Predicting Recurrence of Nonfunctioning Pituitary Adenomas.

T.-W. Noh, H. J. Jeong, M.-K. Lee, T. S. Kim, S. H. Kim, and E. J. Lee (2009)
J. Clin. Endocrinol. Metab. 94, 4406-4413
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNAs Differentially Regulated by Akt Isoforms Control EMT and Stem Cell Renewal in Cancer Cells.

D. Iliopoulos, C. Polytarchou, M. Hatziapostolou, F. Kottakis, I. G. Maroulakou, K. Struhl, and P. N. Tsichlis (2009)
Science Signaling 2, ra62
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Flightless-I as a Substrate of the Cytokine-independent Survival Kinase CISK.

J. Xu, L. Liao, J. Qin, J. Xu, D. Liu, and Z. Songyang (2009)
J. Biol. Chem. 284, 14377-14385
 |  Abstract »  |  Full Text »  |  PDF »

Mammalian Expression of Infrared Fluorescent Proteins Engineered from a Bacterial Phytochrome.

X. Shu, A. Royant, M. Z. Lin, T. A. Aguilera, V. Lev-Ram, P. A. Steinbach, and R. Y. Tsien (2009)
Science 324, 804-807
 |  Abstract »  |  Full Text »  |  PDF »

ExcisaninA, a diterpenoid compound purified from Isodon MacrocalyxinD, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway.

R. Deng, J. Tang, L.-P. Xia, D.-D. Li, W.-J. Zhou, L.-L. Wang, G.-K. Feng, Y.-X. Zeng, Y.-H. Gao, and X.-F. Zhu (2009)
Mol. Cancer Ther. 8, 873-882
 |  Abstract »  |  Full Text »  |  PDF »

Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.

P. Kaur, S. Shukla, and S. Gupta (2008)
Carcinogenesis 29, 2210-2217
 |  Abstract »  |  Full Text »  |  PDF »

Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling.

N. Kakinuma, B. C. Roy, Y. Zhu, Y. Wang, and R. Kiyama (2008)
J. Cell Biol. 181, 537-549
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase B/Akt Phosphorylates and Inhibits the Cardiac Na+/H+ Exchanger NHE1.

A. K. Snabaitis, F. Cuello, and M. Avkiran (2008)
Circ. Res. 103, 881-890
 |  Abstract »  |  Full Text »  |  PDF »

Spatiotemporal Analysis of Differential Akt Regulation in Plasma Membrane Microdomains.

X. Gao and J. Zhang (2008)
Mol. Biol. Cell 19, 4366-4373
 |  Abstract »  |  Full Text »  |  PDF »

Constitutively Active Akt Induces Enhanced Myelination in the CNS.

A. I. Flores, S. P. Narayanan, E. N. Morse, H. E. Shick, X. Yin, G. Kidd, R. L. Avila, D. A. Kirschner, and W. B. Macklin (2008)
J. Neurosci. 28, 7174-7183
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Phosphorylation of Thr-308 of Akt, Cell Proliferation, and Survival by the B55{alpha} Regulatory Subunit Targeting of the Protein Phosphatase 2A Holoenzyme to Akt.

Y.-C. Kuo, K.-Y. Huang, C.-H. Yang, Y.-S. Yang, W.-Y. Lee, and C.-W. Chiang (2008)
J. Biol. Chem. 283, 1882-1892
 |  Abstract »  |  Full Text »  |  PDF »

Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines.

L. Toral-Barza, W.-G. Zhang, X. Huang, L. A. McDonald, E. J. Salaski, L. R. Barbieri, W.-D. Ding, G. Krishnamurthy, Y. B. Hu, J. Lucas, et al. (2007)
Mol. Cancer Ther. 6, 3028-3038
 |  Abstract »  |  Full Text »  |  PDF »

Ca2+/Calmodulin Directly Interacts with the Pleckstrin Homology Domain of AKT1.

B. Dong, C. A. Valencia, and R. Liu (2007)
J. Biol. Chem. 282, 25131-25140
 |  Abstract »  |  Full Text »  |  PDF »

Cholesterol Sensitivity of Endogenous and Myristoylated Akt.

R. M. Adam, N. K. Mukhopadhyay, J. Kim, D. Di Vizio, B. Cinar, K. Boucher, K. R. Solomon, and M. R. Freeman (2007)
Cancer Res. 67, 6238-6246
 |  Abstract »  |  Full Text »  |  PDF »

AKT1 Amplification Regulates Cisplatin Resistance in Human Lung Cancer Cells through the Mammalian Target of Rapamycin/p70S6K1 Pathway.

L.-Z. Liu, X.-D. Zhou, G. Qian, X. Shi, J. Fang, and B.-H. Jiang (2007)
Cancer Res. 67, 6325-6332
 |  Abstract »  |  Full Text »  |  PDF »

PTEN, more than the AKT pathway.

C. Blanco-Aparicio, O. Renner, J. F.M. Leal, and A. Carnero (2007)
Carcinogenesis 28, 1379-1386
 |  Abstract »  |  Full Text »  |  PDF »

Nodal signalling and apoptosis.

H. Wang and B. K Tsang (2007)
Reproduction 133, 847-853
 |  Abstract »  |  Full Text »  |  PDF »

Unequal Contribution of Akt Isoforms in the Double-Negative to Double-Positive Thymocyte Transition.

C. Mao, E. G. Tili, M. Dose, M. C. Haks, S. E. Bear, I. Maroulakou, K. Horie, G. A. Gaitanaris, V. Fidanza, T. Ludwig, et al. (2007)
J. Immunol. 178, 5443-5453
 |  Abstract »  |  Full Text »  |  PDF »

Akt Attenuation of the Serine Protease Activity of HtrA2/Omi through Phosphorylation of Serine 212.

L. Yang, M. Sun, X.-m. Sun, G. Z. Cheng, S. V. Nicosia, and J. Q. Cheng (2007)
J. Biol. Chem. 282, 10981-10987
 |  Abstract »  |  Full Text »  |  PDF »

AKT1 Overexpression in Endothelial Cells Leads to the Development of Cutaneous Vascular Malformations In Vivo.

B. Perry, J. Banyard, E. R. McLaughlin, R. Watnick, A. Sohn, D. N. Brindley, T. Obata, L. C. Cantley, C. Cohen, and J. L. Arbiser (2007)
Arch Dermatol 143, 504-506
 |  Abstract »  |  Full Text »  |  PDF »

Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs.

Y. Tambe, A. Yoshioka-Yamashita, K.-i. Mukaisho, S. Haraguchi, T. Chano, T. Isono, T. Kawai, Y. Suzuki, R. Kushima, T. Hattori, et al. (2007)
Carcinogenesis 28, 777-784
 |  Abstract »  |  Full Text »  |  PDF »

Neuronal Apoptotic Signaling Pathways Probed and Intervened by Synthetically and Modularly Modified (SMM) Chemokines.

W.-T. Choi, M. Kaul, S. Kumar, J. Wang, I. M. K. Kumar, C.-Z. Dong, J. An, S. A. Lipton, and Z. Huang (2007)
J. Biol. Chem. 282, 7154-7163
 |  Abstract »  |  Full Text »  |  PDF »

Protease-Activated Receptor-1 (hPar1), A Survival Factor Eliciting Tumor Progression.

Z. Salah, M. Maoz, E. Pokroy, M. Lotem, R. Bar-Shavit, and B. Uziely (2007)
Mol. Cancer Res. 5, 229-240
 |  Abstract »  |  Full Text »  |  PDF »

Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis.

J. L. Arbiser, T. Kau, M. Konar, K. Narra, R. Ramchandran, S. A. Summers, C. J. Vlahos, K. Ye, B. N. Perry, W. Matter, et al. (2007)
Blood 109, 560-565
 |  Abstract »  |  Full Text »  |  PDF »

Akt1 Ablation Inhibits, whereas Akt2 Ablation Accelerates, the Development of Mammary Adenocarcinomas in Mouse Mammary Tumor Virus (MMTV)-ErbB2/Neu and MMTV-Polyoma Middle T Transgenic Mice.

I. G. Maroulakou, W. Oemler, S. P. Naber, and P. N. Tsichlis (2007)
Cancer Res. 67, 167-177
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative Analysis of Anti-apoptotic Function of Akt in Akt1 and Akt2 Double Knock-out Mouse Embryonic Fibroblast Cells under Normal and Stressed Conditions.

X. Liu, Y. Shi, M. J. Birnbaum, K. Ye, R. De Jong, T. Oltersdorf, V. L. Giranda, and Y. Luo (2006)
J. Biol. Chem. 281, 31380-31388
 |  Abstract »  |  Full Text »  |  PDF »

Interdomain Conformational Changes in Akt Activation Revealed by Chemical Cross-linking and Tandem Mass Spectrometry.

B. X. Huang and H.-Y. Kim (2006)
Mol. Cell. Proteomics 5, 1045-1053
 |  Abstract »  |  Full Text »  |  PDF »

Kinetic Mechanism of AKT/PKB Enzyme Family.

X. Zhang, S. Zhang, H. Yamane, R. Wahl, A. Ali, J. A. Lofgren, and R. L. Kendall (2006)
J. Biol. Chem. 281, 13949-13956
 |  Abstract »  |  Full Text »  |  PDF »

Cyclic and characteristic expression of phosphorylated Akt in human endometrium and decidual cells in vivo and in vitro.

A. Toyofuku, T. Hara, T. Taguchi, Y. Katsura, K. Ohama, and Y. Kudo (2006)
Hum. Reprod. 21, 1122-1128
 |  Abstract »  |  Full Text »  |  PDF »

Relative contribution of G-protein-coupled pathways to protease-activated receptor-mediated Akt phosphorylation in platelets.

S. Kim, J. Jin, and S. P. Kunapuli (2006)
Blood 107, 947-954
 |  Abstract »  |  Full Text »  |  PDF »

Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein.

A. Palamarchuk, A. Efanov, V. Maximov, R. I. Aqeilan, C. M. Croce, and Y. Pekarsky (2005)
Cancer Res. 65, 11282-11286
 |  Abstract »  |  Full Text »  |  PDF »

Akt/Protein Kinase B Activation by Adenovirus Vectors Contributes to NF{kappa}B-Dependent CXCL10 Expression.

Q. Liu, L. R. White, S. A. Clark, D. J. Heffner, B. W. Winston, L. A. Tibbles, and D. A. Muruve (2005)
J. Virol. 79, 14507-14515
 |  Abstract »  |  Full Text »  |  PDF »

Breast Cancer-Associated PIK3CA Mutations Are Oncogenic in Mammary Epithelial Cells.

S. J. Isakoff, J. A. Engelman, H. Y. Irie, J. Luo, S. M. Brachmann, R. V. Pearline, L. C. Cantley, and J. S. Brugge (2005)
Cancer Res. 65, 10992-11000
 |  Abstract »  |  Full Text »  |  PDF »

Bone Morphogenetic Protein-2-Induced Transformation Involves the Activation of Mammalian Target of Rapamycin.

E. M. Langenfeld, Y. Kong, and J. Langenfeld (2005)
Mol. Cancer Res. 3, 679-684
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Cloning and Characterization of the Human AKT1 Promoter Uncovers Its Up-regulation by the Src/Stat3 Pathway.

S. Park, D. Kim, S. Kaneko, K. M. Szewczyk, S. V. Nicosia, H. Yu, R. Jove, and J. Q. Cheng (2005)
J. Biol. Chem. 280, 38932-38941
 |  Abstract »  |  Full Text »  |  PDF »

Mammalian Target of Rapamycin Promotes Vincristine Resistance through Multiple Mechanisms Independent of Maintained Glycolytic Rate.

D. J. VanderWeele and C. M. Rudin (2005)
Mol. Cancer Res. 3, 635-644
 |  Abstract »  |  Full Text »  |  PDF »

AKT Activation Promotes Metastasis in a Mouse Model of Follicular Thyroid Carcinoma.

C. S. Kim, V. V. Vasko, Y. Kato, M. Kruhlak, M. Saji, S.-Y. Cheng, and M. D. Ringel (2005)
Endocrinology 146, 4456-4463
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells.

S. Dihlmann, M. Kloor, C. Fallsehr, and M. von Knebel Doeberitz (2005)
Carcinogenesis 26, 1503-1512
 |  Abstract »  |  Full Text »  |  PDF »

FasL (CD95L/APO-1L) Resistance of Neurons Mediated by Phosphatidylinositol 3-Kinase-Akt/Protein Kinase B-Dependent Expression of Lifeguard/Neuronal Membrane Protein 35.

C. P. Beier, J. Wischhusen, M. Gleichmann, E. Gerhardt, A. Pekanovic, A. Krueger, V. Taylor, U. Suter, P. H. Krammer, M. Endres, et al. (2005)
J. Neurosci. 25, 6765-6774
 |  Abstract »  |  Full Text »  |  PDF »

ArgBP2{gamma} Interacts with Akt and p21-activated Kinase-1 and Promotes Cell Survival.

Z.-q. Yuan, D. Kim, S. Kaneko, M. Sussman, G. M. Bokoch, G. D. Kruh, S. V. Nicosia, J. R. Testa, and J. Q. Cheng (2005)
J. Biol. Chem. 280, 21483-21490
 |  Abstract »  |  Full Text »  |  PDF »

Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.

Y. Luo, A. R. Shoemaker, X. Liu, K. W. Woods, S. A. Thomas, R. de Jong, E. K. Han, T. Li, V. S. Stoll, J. A. Powlas, et al. (2005)
Mol. Cancer Ther. 4, 977-986
 |  Abstract »  |  Full Text »  |  PDF »

{gamma}-Amino Butyric Acid Type B Receptors Stimulate Neutrophil Chemotaxis during Ischemia-Reperfusion.

M. J. Rane, D. Gozal, W. Butt, E. Gozal, W. M. Pierce Jr, S. Z. Guo, R. Wu, A. D. Goldbart, V. Thongboonkerd, K. R. McLeish, et al. (2005)
J. Immunol. 174, 7242-7249
 |  Abstract »  |  Full Text »  |  PDF »

Roles of the Ras-MEK-Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase-Akt-mTOR Pathways in Jaagsiekte Sheep Retrovirus-Induced Transformation of Rodent Fibroblast and Epithelial Cell Lines.

N. Maeda, W. Fu, A. Ortin, M. de las Heras, and H. Fan (2005)
J. Virol. 79, 4440-4450
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Protein Synthesis by Y Box-Binding Protein 1 Blocks Oncogenic Cell Transformation.

A. G. Bader and P. K. Vogt (2005)
Mol. Cell. Biol. 25, 2095-2106
 |  Abstract »  |  Full Text »  |  PDF »

Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles.

E. Yamada, S. Okada, T. Saito, K. Ohshima, M. Sato, T. Tsuchiya, Y. Uehara, H. Shimizu, and M. Mori (2005)
J. Cell Biol. 168, 921-928
 |  Abstract »  |  Full Text »  |  PDF »

Prognostic Significance of Activated Akt Expression in Melanoma: A Clinicopathologic Study of 292 Cases.

D. L. Dai, M. Martinka, and G. Li (2005)
J. Clin. Oncol. 23, 1473-1482
 |  Abstract »  |  Full Text »  |  PDF »

Complex Regulation of the Cyclin-Dependent Kinase Inhibitor p27kip1 in Thyroid Cancer Cells by the PI3K/AKT Pathway: Regulation of p27kip1 Expression and Localization.

M. L. Motti, D. Califano, G. Troncone, C. De Marco, I. Migliaccio, E. Palmieri, L. Pezzullo, L. Palombini, A. Fusco, and G. Viglietto (2005)
Am. J. Pathol. 166, 737-749
 |  Abstract »  |  Full Text »  |  PDF »

Spatio-temporal Dynamics of Protein Kinase B/Akt Signaling Revealed by a Genetically Encoded Fluorescent Reporter.

M. T. Kunkel, Q. Ni, R. Y. Tsien, J. Zhang, and A. C. Newton (2005)
J. Biol. Chem. 280, 5581-5587
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.

S. Kang, A. G. Bader, and P. K. Vogt (2005)
PNAS 102, 802-807
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondria and Cancer: Warburg Addressed.

D.C. WALLACE (2005)
Cold Spring Harb Symp Quant Biol 70, 363-374
 |  Abstract »  |  PDF »

Inhibition of Akt/Protein Kinase B Signaling by Naltrindole in Small Cell Lung Cancer Cells.

Y. L. Chen, P. Y. Law, and H. H. Loh (2004)
Cancer Res. 64, 8723-8730
 |  Abstract »  |  Full Text »  |  PDF »

Putting the Rap on Akt.

J. E. Thompson and C. B. Thompson (2004)
J. Clin. Oncol. 22, 4217-4226
 |  Abstract »  |  Full Text »  |  PDF »

Structural Basis for the Co-activation of Protein Kinase B by T-cell Leukemia-1 (TCL1) Family Proto-oncoproteins.

D. Auguin, P. Barthe, C. Royer, M.-H. Stern, M. Noguchi, S. T. Arold, and C. Roumestand (2004)
J. Biol. Chem. 279, 35890-35902
 |  Abstract »  |  Full Text »  |  PDF »

The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway.

I. Sansal and W. R. Sellers (2004)
J. Clin. Oncol. 22, 2954-2963
 |  Abstract »  |  Full Text »  |  PDF »

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt.

J.-Y. Ahn, Y. Hu, T. G. Kroll, P. Allard, and K. Ye (2004)
PNAS 101, 6993-6998
 |  Abstract »  |  Full Text »  |  PDF »

The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival.

S. Cooray (2004)
J. Gen. Virol. 85, 1065-1076
 |  Abstract »  |  Full Text »  |  PDF »

Role of Protein Kinase B-Dependent Signaling in Lung Tumorigenesis.

J. M. Kurie (2004)
Chest 125, 141S-144S
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase B/Akt Regulates Coxsackievirus B3 Replication through a Mechanism Which Is Not Caspase Dependent.

M. Esfandiarei, H. Luo, B. Yanagawa, A. Suarez, D. Dabiri, J. Zhang, and B. M. McManus (2004)
J. Virol. 78, 4289-4298
 |  Abstract »  |  Full Text »  |  PDF »

Preferential Inhibition of Akt and Killing of Akt-Dependent Cancer Cells by Rationally Designed Phosphatidylinositol Ether Lipid Analogues.

S. S. Castillo, J. Brognard, P. A. Petukhov, C. Zhang, J. Tsurutani, C. A. Granville, M. Li, M. Jung, K. A. West, J. G. Gills, et al. (2004)
Cancer Res. 64, 2782-2792
 |  Abstract »  |  Full Text »  |  PDF »

Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP{alpha} growth inhibitory activity.

G.-L. Wang, P. Iakova, M. Wilde, S. Awad, and N. A. Timchenko (2004)
Genes & Dev. 18, 912-925
 |  Abstract »  |  Full Text »  |  PDF »

Akt Phosphorylation and Stabilization of X-linked Inhibitor of Apoptosis Protein (XIAP).

H. C. Dan, M. Sun, S. Kaneko, R. I. Feldman, S. V. Nicosia, H.-G. Wang, B. K. Tsang, and J. Q. Cheng (2004)
J. Biol. Chem. 279, 5405-5412
 |  Abstract »  |  Full Text »  |  PDF »

Akt Activation in Platelets Depends on Gi Signaling Pathways.

S. Kim, J. Jin, and S. P. Kunapuli (2004)
J. Biol. Chem. 279, 4186-4195
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor Receptor-dependent, NF-{kappa}B-independent Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway Inhibits Ultraviolet Irradiation-induced Caspases-3, -8, and -9 in Human Keratinocytes.

H. Q. Wang, T. Quan, T. He, T. F. Franke, J. J. Voorhees, and G. J. Fisher (2003)
J. Biol. Chem. 278, 45737-45745
 |  Abstract »  |  Full Text »  |  PDF »

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival.

J. C. Rathmell, C. J. Fox, D. R. Plas, P. S. Hammerman, R. M. Cinalli, and C. B. Thompson (2003)
Mol. Cell. Biol. 23, 7315-7328
 |  Abstract »  |  Full Text »  |  PDF »

Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway.

A. G. Bader, K. A. Felts, N. Jiang, H. W. Chang, and P. K. Vogt (2003)
PNAS 100, 12384-12389
 |  Abstract »  |  Full Text »  |  PDF »

Specificity in the activation and control of transcription factor E2F-dependent apoptosis.

T. C. Hallstrom and J. R. Nevins (2003)
PNAS 100, 10848-10853
 |  Abstract »  |  Full Text »  |  PDF »

Transformation of Mouse Fibroblasts by Jaagsiekte Sheep Retrovirus Envelope Does Not Require Phosphatidylinositol 3-Kinase.

N. Maeda, Y. Inoshima, D. A. Fruman, S. M. Brachmann, and H. Fan (2003)
J. Virol. 77, 9951-9959
 |  Abstract »  |  Full Text »  |  PDF »

Osteopontin Stimulates Cell Motility and Nuclear Factor {kappa}B-mediated Secretion of Urokinase Type Plasminogen Activator through Phosphatidylinositol 3-Kinase/Akt Signaling Pathways in Breast Cancer Cells.

R. Das, G. H. Mahabeleshwar, and G. C. Kundu (2003)
J. Biol. Chem. 278, 28593-28606
 |  Abstract »  |  Full Text »  |  PDF »

Adrenomedullin Reduces VEGF-Induced Endothelial Adhesion Molecules and Adhesiveness Through a Phosphatidylinositol 3'-Kinase Pathway.

W. Kim, S.-O. Moon, S. Lee, M. J. Sung, S. H. Kim, and S. K. Park (2003)
Arterioscler Thromb Vasc Biol 23, 1377-1383
 |  Abstract »  |  Full Text »  |  PDF »

Use of RNA Interference-mediated Gene Silencing and Adenoviral Overexpression to Elucidate the Roles of AKT/Protein Kinase B Isoforms in Insulin Actions.

T. Katome, T. Obata, R. Matsushima, N. Masuyama, L. C. Cantley, Y. Gotoh, K. Kishi, H. Shiota, and Y. Ebina (2003)
J. Biol. Chem. 278, 28312-28323
 |  Abstract »  |  Full Text »  |  PDF »

Increased Phospho-AKT (Ser473) Expression in Bronchial Dysplasia: Implications for Lung Cancer Prevention Studies.

A. S. Tsao, T. McDonnell, S. Lam, J. B. Putnam, N. Bekele, W. K. Hong, and J. M. Kurie (2003)
Cancer Epidemiol. Biomarkers Prev. 12, 660-664
 |  Abstract »  |  Full Text »  |  PDF »

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model.

P. K. Majumder, J. J. Yeh, D. J. George, P. G. Febbo, J. Kum, Q. Xue, R. Bikoff, H. Ma, P. W. Kantoff, T. R. Golub, et al. (2003)
PNAS 100, 7841-7846
 |  Abstract »  |  Full Text »  |  PDF »

Evidence That Phosphatidylinositol 3-Kinase- and Mitogen-activated Protein Kinase Kinase-4/c-Jun NH2-terminal Kinase-dependent Pathways Cooperate to Maintain Lung Cancer Cell Survival.

H.-Y. Lee, H. Srinivas, D. Xia, Y. Lu, R. Superty, R. LaPushin, C. Gomez-Manzano, A. M. Gal, G. L. Walsh, T. Force, et al. (2003)
J. Biol. Chem. 278, 23630-23638
 |  Abstract »  |  Full Text »  |  PDF »

Akt as a possible intracellular mediator for decidualization in human endometrial stromal cells.

O. Yoshino, Y. Osuga, Y. Hirota, K. Koga, T. Yano, O. Tsutsumi, and Y. Taketani (2003)
Mol. Hum. Reprod. 9, 265-269
 |  Abstract »  |  Full Text »  |  PDF »

Targeting the Phosphatidylinositol 3-Kinase/Akt Pathway for Enhancing Breast Cancer Cells to Radiotherapy.

K. Liang, W. Jin, C. Knuefermann, M. Schmidt, G. B. Mills, K. K. Ang, L. Milas, and Z. Fan (2003)
Mol. Cancer Ther. 2, 353-360
 |  Abstract »  |  Full Text »  |  PDF »

Akt Activation Promotes Degradation of Tuberin and FOXO3a via the Proteasome.

D. R. Plas and C. B. Thompson (2003)
J. Biol. Chem. 278, 12361-12366
 |  Abstract »  |  Full Text »  |  PDF »

Akt as a Mediator of Secretory Phospholipase A2 Receptor-Involved Inducible Nitric Oxide Synthase Expression.

D.-W. Park, J.-R. Kim, S.-Y. Kim, J.-K. Sonn, O.-S. Bang, S.-S. Kang, J.-H. Kim, and S.-H. Baek (2003)
J. Immunol. 170, 2093-2099
 |  Abstract »  |  Full Text »  |  PDF »

Dopamine Induces a PI3-Kinase-Independent Activation of Akt in Striatal Neurons: A New Route to cAMP Response Element-Binding Protein Phosphorylation.

K. Brami-Cherrier, E. Valjent, M. Garcia, C. Pages, R. A. Hipskind, and J. Caboche (2002)
J. Neurosci. 22, 8911-8921
 |  Abstract »  |  Full Text »  |  PDF »

Simian Virus 40 Small Tumor Antigen Activates AKT and Telomerase and Induces Anchorage-Independent Growth of Human Epithelial Cells.

H. Yuan, T. Veldman, K. Rundell, and R. Schlegel (2002)
J. Virol. 76, 10685-10691
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Signal Transduction Pathways Involved in Rheumatoid Arthritis Synovial Fibroblast Interleukin-18-induced Vascular Cell Adhesion Molecule-1 Expression.

J. C. M. Morel, C. C. Park, K. Zhu, P. Kumar, J. H. Ruth, and A. E. Koch (2002)
J. Biol. Chem. 277, 34679-34691
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The Role of Asp-462 in Regulating Akt Activity.

J. Xu, D. Liu, and Z. Songyang (2002)
J. Biol. Chem. 277, 35561-35566
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Glycogen Synthase Kinase 3beta Is Activated by cAMP and Plays an Active Role in the Regulation of Melanogenesis.

M. Khaled, L. Larribere, K. Bille, E. Aberdam, J.-P. Ortonne, R. Ballotti, and C. Bertolotto (2002)
J. Biol. Chem. 277, 33690-33697
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Phosphoinositide 3-Kinase-Dependent Steps in Activation of Protein Kinase B.

M. P. Scheid, P. A. Marignani, and J. R. Woodgett (2002)
Mol. Cell. Biol. 22, 6247-6260
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The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP3 levels.

S. Oldham, H. Stocker, M. Laffargue, F. Wittwer, M. Wymann, and E. Hafen (2002)
Development 129, 4103-4109
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Insulin-like Growth Factor-1-mediated AKT Activation Postpones the Onset of Ultraviolet B-induced Apoptosis, Providing More Time for Cyclobutane Thymine Dimer Removal in Primary Human Keratinocytes.

D. Decraene, P. Agostinis, R. Bouillon, H. Degreef, and M. Garmyn (2002)
J. Biol. Chem. 277, 32587-32595
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cAMP Inhibition of Akt Is Mediated by Activated and Phosphorylated Rap1b.

L. Lou, J. Urbani, F. Ribeiro-Neto, and D. L. Altschuler (2002)
J. Biol. Chem. 277, 32799-32806
 |  Abstract »  |  Full Text »  |  PDF »

Akt-Dependent Phosphorylation Specifically Regulates Cot Induction of NF-{kappa}B-Dependent Transcription.

L. P. Kane, M. N. Mollenauer, Z. Xu, C. W. Turck, and A. Weiss (2002)
Mol. Cell. Biol. 22, 5962-5974
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of JNK by Cellular Stress- and Tumor Necrosis Factor alpha -induced AKT2 through Activation of the NFkappa B Pathway in Human Epithelial Cells.

Z.-q. Yuan, R. I. Feldman, M. Sun, N. E. Olashaw, D. Coppola, G. E. Sussman, S. A. Shelley, S. V. Nicosia, and J. Q. Cheng (2002)
J. Biol. Chem. 277, 29973-29982
 |  Abstract »  |  Full Text »  |  PDF »

Cross-Linking CD98 Promotes Integrin-like Signaling and Anchorage-independent Growth.

R. C. Rintoul, R. C. Buttery, A. C Mackinnon, W. S. Wong, D. Mosher, C. Haslett, and T. Sethi (2002)
Mol. Biol. Cell 13, 2841-2852
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive and Inducible Akt Activity Promotes Resistance to Chemotherapy, Trastuzumab, or Tamoxifen in Breast Cancer Cells.

A. S. Clark, K. West, S. Streicher, and P. A. Dennis (2002)
Mol. Cancer Ther. 1, 707-717
 |  Abstract »  |  Full Text »  |  PDF »

Inactivation of the Antiapoptotic Phosphatidylinositol 3-Kinase-Akt Pathway by the Combined Treatment of Taxol and Mitogen-activated Protein Kinase Kinase Inhibition.

J. P. MacKeigan, D. J. Taxman, D. Hunter, H. S. Earp III, L. M. Graves, and J. P-Y. Ting (2002)
Clin. Cancer Res. 8, 2091-2099
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Nuclear Factor {kappa}B Activation in PC3 Cells by Genistein Is Mediated via Akt Signaling Pathway.

Y. Li and F. H. Sarkar (2002)
Clin. Cancer Res. 8, 2369-2377
 |  Abstract »  |  Full Text »  |  PDF »

Role of Akt Signaling in Vascular Homeostasis and Angiogenesis.

I. Shiojima and K. Walsh (2002)
Circ. Res. 90, 1243-1250
 |  Abstract »  |  Full Text »  |  PDF »

Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53.

Y. Ogawara, S. Kishishita, T. Obata, Y. Isazawa, T. Suzuki, K. Tanaka, N. Masuyama, and Y. Gotoh (2002)
J. Biol. Chem. 277, 21843-21850
 |  Abstract »  |  Full Text »  |  PDF »

Envelope-Induced Cell Transformation by Ovine Betaretroviruses.

A. Alberti, C. Murgia, S.-L. Liu, M. Mura, C. Cousens, M. Sharp, A. D. Miller, and M. Palmarini (2002)
J. Virol. 76, 5387-5394
 |  Abstract »  |  Full Text »  |  PDF »

Critical Involvement of the Phosphatidylinositol 3-Kinase/Akt Pathway in Anchorage-independent Growth and Hematogeneous Intrahepatic Metastasis of Liver Cancer.

K. Nakanishi, M. Sakamoto, J. Yasuda, M. Takamura, N. Fujita, T. Tsuruo, S. Todo, and S. Hirohashi (2002)
Cancer Res. 62, 2971-2975
 |  Abstract »  |  Full Text »  |  PDF »

Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes.

K. Vosseller, L. Wells, M. D. Lane, and G. W. Hart (2002)
PNAS 99, 5313-5318
 |  Abstract »  |  Full Text »  |  PDF »

PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?.

M. A. Lawlor and D. R. Alessi (2002)
J. Cell Sci. 114, 2903-2910
 |  Abstract »  |  Full Text »  |  PDF »

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