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Science 4 October 1991:
Vol. 254. no. 5028, pp. 99 - 102
DOI: 10.1126/science.1718038
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Articles

Science, Vol 254, Issue 5028, 99-102
Copyright © 1991 by American Association for the Advancement of Science

articles

Regulation of transendothelial neutrophil migration by endogenous interleukin-8

AR Huber, SL Kunkel, RF Todd 3rd, and SJ Weiss

Department of Internal Medicine, University of Michigan, Ann Arbor 48109.

Movement of neutrophils from the bloodstream to inflamed tissue depends on the activation of both the neutrophil and the endothelial cell. Endothelial cells lining the postcapillary venule respond to proinflammatory mediators by expressing adhesion molecules and synthesizing a variety of neutrophil-activating factors. Endothelial cell production of a 77-amino acid variant of interleukin-8 (IL-8) was found to be a requirement for the invasion of neutrophils through a vessel wall model. IL-8 secreted by cytokine- or lipopolysaccharide-stimulated endothelial cells induced the rapid shedding of neutrophil lectin adhesion molecule-1, the up-regulation of leukocyte beta 2 integrins, and the attachment and transmigration of the neutrophils. Thus, endogenous endothelial IL-8 regulates transvenular traffic during acute inflammatory responses.


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PNAS 95, 258-263
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Differential Regulation of Interleukin-8 and Intercellular Adhesion Molecule-1 by H2O2 and Tumor Necrosis Factor-alpha in Endothelial and Epithelial Cells.
V. Lakshminarayanan, D. W. A. Beno, R. H. Costa, and K. A. Roebuck (1997)
J. Biol. Chem. 272, 32910-32918
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Interleukin 8 released after acute myocardial infarction is mainly bound to erythrocytes.
R. J de Winter, A. Manten, Y. P de Jong, R. Adams, S. J H van Deventer, and K. I Lie (1997)
Heart 78, 598-602
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Tumor Necrosis Factor alpha -Induced Eosinophil Accumulation in Rat Skin Is Dependent on alpha 4 Integrin/Vascular Cell Adhesion Molecule-1 Adhesion Pathways.
M.-J. Sanz, A. Hartnell, P. Chisholm, C. Williams, D. Davies, V. B. Weg, M. Feldmann, M. A. Bolanowski, R. R. Lobb, and S. Nourshargh (1997)
Blood 90, 4144-4152
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Human Endothelial Cells Synthesize ENA-78: Relationship to IL-8 and to Signaling of PMN Adhesion.
T.-a. Imaizumi, K. H. Albertine, D. L. Jicha, T. M. McIntyre, S. M. Prescott, and G. A. Zimmerman (1997)
Am. J. Respir. Cell Mol. Biol. 17, 181-192
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Chemokines.
B. J. Rollins (1997)
Blood 90, 909-928
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