Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Career Basics

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 6 September 1991:
Vol. 253. no. 5024, pp. 1132 - 1135
DOI: 10.1126/science.1653455

Articles

Science, Vol 253, Issue 5024, 1132-1135
Copyright © 1991 by American Association for the Advancement of Science


articles

Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases

LY Wang, MW Salter, and JF MacDonald

Department of Physiology, University of Toronto, Ontario, Canada.

In the mammalian central nervous system, receptors for excitatory amino acid neurotransmitters such as the alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid (AMPA)-kainate receptor mediate a large fraction of excitatory transmission. Currents induced by activation of the AMPA-kainate receptor were potentiated by agents that specifically stimulate adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase A (PKA) activity or were supported by intracellular application of the catalytic subunit of PKA by itself or in combination with cAMP. Furthermore, depression of these currents by a competitive inhibitor of PKA indicates that AMPA-kainate receptors are regulated by endogenous PKA. Endogenous protein phosphatases also regulate these receptors because an inhibitor of cellular phosphates enhanced kainate currents. Modulation of PKA and phosphatases may regulate the function of these receptors and thus contribute to synaptic plasticity in hippocampal neurons.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Activation of Pedunculopontine Tegmental PKA Prevents GABAB Receptor Activation-Mediated Rapid Eye Movement Sleep Suppression in the Freely Moving Rat.
S. Datta (2007)
J Neurophysiol 97, 3841-3850
   Abstract »    Full Text »    PDF »
Acute Injury to Superficial Cortex Leads to a Decrease in Synaptic Inhibition and Increase in Excitation in Neocortical Layer V Pyramidal Cells.
L. Yang, L. S. Benardo, H. Valsamis, and D. S. F. Ling (2007)
J Neurophysiol 97, 178-187
   Abstract »    Full Text »    PDF »
Octopamine Mediates Thermal Preconditioning of the Locust Ventilatory Central Pattern Generator via a cAMP/Protein Kinase A Signaling Pathway..
G. A. B. Armstrong, K. L. Shoemaker, T. G. A. Money, and R. M. Robertson (2006)
J. Neurosci. 26, 12118-12126
   Abstract »    Full Text »    PDF »
Activation of pedunculopontine tegmental protein kinase a: a mechanism for rapid eye movement sleep generation in the freely moving rat..
R. S. Bandyopadhya, S. Datta, and S. Saha (2006)
J. Neurosci. 26, 8931-8942
   Abstract »    Full Text »    PDF »
Postsynaptic Mechanisms Are Essential for Forskolin-Induced Potentiation of Synaptic Transmission.
I. V. Sokolova, H. A. Lester, and N. Davidson (2006)
J Neurophysiol 95, 2570-2579
   Abstract »    Full Text »    PDF »
Novel Role of Brain Stem Pedunculopontine Tegmental Adenylyl Cyclase in the Regulation of Spontaneous REM Sleep in the Freely Moving Rat.
S. Datta and S. L. Prutzman (2005)
J Neurophysiol 94, 1928-1937
   Abstract »    Full Text »    PDF »
Neurosteroid-Induced Plasticity of Immature Synapses via Retrograde Modulation of Presynaptic NMDA Receptors.
M. Mameli, M. Carta, L. D. Partridge, and C. F. Valenzuela (2005)
J. Neurosci. 25, 2285-2294
   Abstract »    Full Text »    PDF »
Localized Effects of cAMP Mediated by Distinct Routes of Protein Kinase A.
K. TASKEN and E. M. AANDAHL (2004)
Physiol Rev 84, 137-167
   Abstract »    Full Text »    PDF »
Mutation and Activation of Galpha s Similarly Alters Pre- and Postsynaptic Mechanisms Modulating Neurotransmission.
R. B. Renden and K. Broadie (2003)
J Neurophysiol 89, 2620-2638
   Abstract »    Full Text »    PDF »
Dynamic Modulation of Inspiratory Drive Currents by Protein Kinase A and Protein Phosphatases in Functionally Active Motoneurons.
C. M. Bocchiaro, S. A. Saywell, and J. L. Feldman (2003)
J. Neurosci. 23, 1099-1103
   Abstract »    Full Text »    PDF »
Postsynaptic Application of a Peptide Inhibitor of cAMP-Dependent Protein Kinase Blocks Expression of Long-Lasting Synaptic Potentiation in Hippocampal Neurons.
S. N. Duffy and P. V. Nguyen (2003)
J. Neurosci. 23, 1142-1150
   Abstract »    Full Text »    PDF »
The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells.
K. Bshesh, B. Zhao, D. Spight, I. Biaggioni, I. Feokistov, A. Denenberg, H. R. Wong, and T. P. Shanley (2002)
J. Leukoc. Biol. 72, 1027-1036
   Abstract »    Full Text »    PDF »
The Neuronal Actin-binding Proteins, Neurabin I and Neurabin II, Recruit Specific Isoforms of Protein Phosphatase-1 Catalytic Subunits.
R. T. Terry-Lorenzo, L. C. Carmody, J. W. Voltz, J. H. Connor, S. Li, F. D. Smith, S. L. Milgram, R. J. Colbran, and S. Shenolikar (2002)
J. Biol. Chem. 277, 27716-27724
   Abstract »    Full Text »    PDF »
Interaction between Metabotropic and NMDA Subtypes of Glutamate Receptors in Sprout Suppression at Young Synapses.
F. Miskevich, W. Lu, S.-Y. Lin, and M. Constantine-Paton (2002)
J. Neurosci. 22, 226-238
   Abstract »    Full Text »    PDF »
Presynaptic H3 Autoreceptors Modulate Histamine Synthesis through cAMP Pathway.
J. Gomez-Ramirez, J. Ortiz, and I. Blanco (2002)
Mol. Pharmacol. 61, 239-245
   Abstract »    Full Text »    PDF »
The Neurobiology of Slow Synaptic Transmission.
P. Greengard (2001)
Science 294, 1024-1030
   Abstract »    Full Text »    PDF »
Complestatin Is a Noncompetitive Peptide Antagonist of N-Methyl-D-aspartate and alpha -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/Kainate Receptors: Secure Blockade of Ischemic Neuronal Death.
S. Y. Seo, B.-S. Yun, I.-J. Ryoo, J.-S. Choi, C.-K. Joo, S.-Y. Chang, J.-M. Chung, S. Oh, B. J. Gwag, and I. D. Yoo (2001)
J. Pharmacol. Exp. Ther. 299, 377-384
   Abstract »    Full Text »    PDF »
Cellular and Synaptic Adaptations Mediating Opioid Dependence.
J. T. Williams, M. J. Christie, and O. Manzoni (2001)
Physiol Rev 81, 299-343
   Abstract »    Full Text »    PDF »
Neuroprotective Role of Dopamine Against Hippocampal Cell Death.
Y. Bozzi, D. Vallone, and E. Borrelli (2000)
J. Neurosci. 20, 8643-8649
   Abstract »    Full Text »    PDF »
PACAP-38 Enhances Excitatory Synaptic Transmission in the Rat Hippocampal CA1 Region.
M. Roberto and M. Brunelli (2000)
Learn. Mem. 7, 303-311
   Abstract »    Full Text »
Spinophilin regulates the formation and function of dendritic spines.
J. Feng, Z. Yan, A. Ferreira, K. Tomizawa, J. A. Liauw, M. Zhuo, P. B. Allen, C. C. Ouimet, and P. Greengard (2000)
PNAS 97, 9287-9292
   Abstract »    Full Text »    PDF »
Regulation of Phosphorylation of the GluR1 AMPA Receptor in the Neostriatum by Dopamine and Psychostimulants In Vivo.
G. L. Snyder, P. B. Allen, A. A. Fienberg, C. G. Valle, R. L. Huganir, A. C. Nairn, and P. Greengard (2000)
J. Neurosci. 20, 4480-4488
   Abstract »    Full Text »    PDF »
Neurofilament-L Is a Protein Phosphatase-1-binding Protein Associated with Neuronal Plasma Membrane and Post-synaptic Density.
R. T. Terry-Lorenzo, M. Inoue, J. H. Connor, T. A. J. Haystead, B. N. Armbruster, R. P. Gupta, C. J. Oliver, and S. Shenolikar (2000)
J. Biol. Chem. 275, 2439-2446
   Abstract »    Full Text »    PDF »
Control of GluR1 AMPA Receptor Function by cAMP-Dependent Protein Kinase.
T. G. Banke, D. Bowie, H.-K. Lee, R. L. Huganir, A. Schousboe, and S. F. Traynelis (2000)
J. Neurosci. 20, 89-102
   Abstract »    Full Text »    PDF »
Platelet-derived Growth Factor Receptor-induced Feed-forward Inhibition of Excitatory Transmission between Hippocampal Pyramidal Neurons.
S. Lei, W.-Y. Lu, Z.-G. Xiong, B. A. Orser, C. F. Valenzuela, and J. F. MacDonald (1999)
J. Biol. Chem. 274, 30617-30623
   Abstract »    Full Text »    PDF »
Enhancement of AMPA-Mediated Current after Traumatic Injury in Cortical Neurons.
P. B. Goforth, E. F. Ellis, and L. S. Satin (1999)
J. Neurosci. 19, 7367-7374
   Abstract »    Full Text »    PDF »
Sulfate Is Both a Substrate and an Activator of the Voltage-Dependent Anion Channel of Arabidopsis Hypocotyl Cells.
J.-M. Frachisse, S. Thomine, J. Colcombet, J. Guern, and H. Barbier-Brygoo (1999)
Plant Physiology 121, 253-262
   Abstract »    Full Text »
Characterization of Phosphorylation Sites on the Glutamate Receptor 4 Subunit of the AMPA Receptors.
A. L. Carvalho, K. Kameyama, and R. L. Huganir (1999)
J. Neurosci. 19, 4748-4754
   Abstract »    Full Text »    PDF »
Neuroprotection at Drosophila Synapses Conferred by Prior Heat Shock.
S. Karunanithi, J. W. Barclay, R. M. Robertson, I. R. Brown, and H. L. Atwood (1999)
J. Neurosci. 19, 4360-4369
   Abstract »    Full Text »    PDF »
Necessary Role for Ventral Tegmental Area Adenylate Cyclase and Protein Kinase A in Induction of Behavioral Sensitization to Intraventral Tegmental Area Amphetamine.
B. K. Tolliver, L. B. Ho, L. M. Fox, and S. P. Berger (1999)
J. Pharmacol. Exp. Ther. 289, 38-47
   Abstract »    Full Text »
Insulin stimulates the L-type Ca2+ current in rat cardiac myocytes.
F. Aulbach, A. Simm, S. Maier, H. Langenfeld, U. Walter, U. Kersting, and M. Kirstein (1999)
Cardiovasc Res 42, 113-120
   Abstract »    Full Text »    PDF »
Ca2+/calmodulin-kinase II enhances channel conductance of alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors.
V. Derkach, A. Barria, and T. R. Soderling (1999)
PNAS 96, 3269-3274
   Abstract »    Full Text »    PDF »
The Glutamate Receptor Ion Channels.
R. Dingledine, K. Borges, D. Bowie, and S. F. Traynelis (1999)
Pharmacol. Rev. 51, 7-62
   Abstract »    Full Text »    PDF »
Different Training Procedures Recruit Either One or Two Critical Periods for Contextual Memory Consolidation, Each of Which Requires Protein Synthesis and PKA.
R. Bourtchouladze, T. Abel, N. Berman, R. Gordon, K. Lapidus, and E. R. Kandel (1998)
Learn. Mem. 5, 365-374
   Abstract »    Full Text »
Multiple Second-Messenger System Modulation of Voltage-Activated Calcium Currents in Teleost Retinal Horizontal Cells.
C. L. Pfeiffer-Linn and E. M. Lasater (1998)
J Neurophysiol 80, 377-388
   Abstract »    Full Text »    PDF »
Activity-Dependent Regulation of [Ca2+]i in Avian Cochlear Nucleus Neurons: Roles of Protein Kinases A and C and Relation to Cell Death.
L. Zirpel, W. R. Lippe, and E. W Rubel (1998)
J Neurophysiol 79, 2288-2302
   Abstract »    Full Text »    PDF »
Galpha s-Induced Neurodegeneration in Caenorhabditis elegans.
A. J. Berger, A. C. Hart, and J. M. Kaplan (1998)
J. Neurosci. 18, 2871-2880
   Abstract »    Full Text »    PDF »
The phosphoprotein DARPP-32 mediates cAMP-dependent potentiation of striatal N-methyl-D-aspartate responses.
T. Blank, I. Nijholt, U. Teichert, H. Kugler, H. Behrsing, A. Fienberg, P. Greengard, and J. Spiess (1997)
PNAS 94, 14859-14864
   Abstract »    Full Text »    PDF »
NMDA-Independent LTP by Adenosine A2 Receptor-Mediated Postsynaptic AMPA Potentiation in Hippocampus.
K. Kessey and D. J. Mogul (1997)
J Neurophysiol 78, 1965-1972
   Abstract »    Full Text »    PDF »
cAMP and protein kinase A modulate cholinergic rapid eye movement sleep generation.
M. L. Capece and R. Lydic (1997)
Am J Physiol Regulatory Integrative Comp Physiol 273, R1430-R1440
   Abstract »    Full Text »    PDF »
Dopaminergic Modulation of Excitatory Postsynaptic Currents in Rat Neostriatal Neurons.
M. Umemiya and L. A. Raymond (1997)
J Neurophysiol 78, 1248-1255
   Abstract »    Full Text »    PDF »
Involvement of cAMP-Dependent Protein Kinase in µ-Opioid Modulation of NMDA-Mediated Synaptic Currents.
C.-W. Xie and D. V. Lewis (1997)
J Neurophysiol 78, 759-766
   Abstract »    Full Text »    PDF »
Experimental Down-Regulation of the NMDA Channel Associated With Synapse Pruning.
P. W. Hickmott and M. Constantine-Paton (1997)
J Neurophysiol 78, 1096-1107
   Abstract »    Full Text »    PDF »
Potentiation of NMDA Currents by Pituitary Adenylate Cyclase Activating Polypeptide in Neonatal Rat Sympathetic Preganglionic Neurons.
S. Y. Wu and N. J. Dun (1997)
J Neurophysiol 78, 1175-1179
   Abstract »    Full Text »    PDF »
Identification of a 15-kDa cAMP-dependent Protein Kinase-anchoring Protein Associated with Skeletal Muscle L-type Calcium Channels.
P. C. Gray, V. C. Tibbs, W. A. Catterall, and B. J. Murphy (1997)
J. Biol. Chem. 272, 6297-6302
   Abstract »    Full Text »    PDF »
cAMP-Dependent Protein Kinase Modulates Expiratory Neurons In Vivo.
P. M. Lalley, O. Pierrefiche, A. M. Bischoff, and D. W. Richter (1997)
J Neurophysiol 77, 1119-1131
   Abstract »    Full Text »    PDF »
Arg-Gly-Asp-Ser-Selective Adhesion and the Stabilization of Long-Term Potentiation: Pharmacological Studies and the Characterization of a Candidate Matrix Receptor.
B. A. Bahr, U. Staubli, P. Xiao, D. Chun, Z.-X. Ji, E. T. Esteban, and G. Lynch (1997)
J. Neurosci. 17, 1320-1329
   Abstract »    Full Text »    PDF »
cAMP-dependent Facilitation of Glutamate Release by beta -Adrenergic Receptors in Cerebrocortical Nerve Terminals.
I. Herrero and J. Sanchez-Prieto (1996)
J. Biol. Chem. 271, 30554-30560
   Abstract »    Full Text »    PDF »
Induction of Hippocampal Long-Term Depression Requires Release of Ca2+ from Separate Presynaptic and Postsynaptic Intracellular Stores.
M. Reyes and P. K. Stanton (1996)
J. Neurosci. 16, 5951-5960
   Abstract »    Full Text »    PDF »
A New Cyclic AMP-independent, Gs-mediated Stimulatory Mechanism via the Adenosine A2a Receptor in the Intact Cardiac Cell.
B. T. Liang and J. F. Morley (1996)
J. Biol. Chem. 271, 18678-18685
   Abstract »    Full Text »    PDF »
17beta -Estradiol Potentiates Kainate-Induced Currents via Activation of the cAMP Cascade.
Q. Gu and R. L. Moss (1996)
J. Neurosci. 16, 3620-3629
   Abstract »    Full Text »    PDF »
Long-lasting forms of synaptic potentiation in the mammalian hippocampus..
Y Y Huang, P V Nguyen, T Abel, and E R Kandel (1996)
Learn. Mem. 3, 74-85
   PDF »
Mutagenesis of the Regulatory Subunit (RIIbeta) of cAMP-dependent Protein Kinase IIbeta Reveals Hydrophobic Amino Acids That Are Essential for RIIbeta Dimerization and/or Anchoring RIIbeta to the Cytoskeleton.
Y. Li and C. S. Rubin (1995)
J. Biol. Chem. 270, 1935-1944
   Abstract »    Full Text »    PDF »
Cyclic AMP modulates the rate of 'constitutive' exocytosis of apical membrane proteins in Madin-Darby canine kidney cells.
M Brignoni, O. Pignataro, M. Rodriguez, A Alvarez, D. Vega-Salas, E Rodriguez-Boulan, and P. Salas (1995)
J. Cell Sci. 108, 1931-1943
   Abstract »    PDF »
A critical period of protein kinase activity after tetanic stimulation is required for the induction of long-term potentiation..
K M Huber, M D Mauk, C Thompson, and P T Kelly (1995)
Learn. Mem. 2, 81-100
   Abstract »    PDF »
Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization..
Y Y Huang and E R Kandel (1994)
Learn. Mem. 1, 74-82
   Abstract »    PDF »
An essential role for protein phosphatases in hippocampal long-term depression.
R. Mulkey, C. Herron, and R. Malenka (1993)
Science 261, 1051-1055
   Abstract »    PDF »
Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons.
U Frey, Y. Huang, and E. Kandel (1993)
Science 260, 1661-1664
   Abstract »    PDF »
Phosphorylation and modulation of a kainate receptor (GluR6) by cAMP-dependent protein kinase.
L. Wang, F. Taverna, X. Huang, J. MacDonald, and D. Hampson (1993)
Science 259, 1173-1175
   Abstract »    PDF »
Src-mediated Tyrosine Phosphorylation of NR2 Subunits of N-Methyl-D-Aspartate Receptors Protects from Calpain-mediated Truncation of Their C-terminal Domains.
R. Bi, Y. Rong, A. Bernard, M. Khrestchatisky, and M. Baudry (2000)
J. Biol. Chem. 275, 26477-26483
   Abstract »    Full Text »    PDF »



ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)