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Science 30 August 1991:
Vol. 253. no. 5023, pp. 1022 - 1026
DOI: 10.1126/science.1887216
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Articles

Science, Vol 253, Issue 5023, 1022-1026
Copyright © 1991 by American Association for the Advancement of Science

articles

Differential phosphorylation of the transcription factor Oct1 during the cell cycle

SB Roberts, N Segil, and N Heintz

Howard Hughes Medical Institute, Laboratory of Molecular Biology, Rockefeller University, New York, NY 10021.

Orderly progression through the somatic cell division cycle is accompanied by phase-specific transcription of a variety of different genes. During S phase, transcription of mammalian histone H2B genes requires a specific promoter element and its cognate transcription factor Oct1 (OTF1). A possible mechanism for regulating histone H2B transcription during the cell cycle is direct modulation of Oct1 activity by phase-specific posttranslational modifications. Analysis of Oct1 during progression through the cell cycle revealed a complex temporal program of phosphorylation. A p34cdc2-related protein kinase that is active during mitosis may be responsible for one mitotic phosphorylation of Oct1. However, the temporally controlled appearance of Oct1 phosphopeptides suggests the involvement of multiple kinases and phosphatases. These results support the idea that cell cycle-regulated transcription factors may be direct substrates for phase-specific regulatory enzymes.


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J. Virol. 72, 5626-5637
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Cell Cycle-regulated Expression of the Muscle Determination Factor Myf5 in Proliferating Myoblasts.
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Mitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNA-binding activity..
J L Volker, L E Rameh, Q Zhu, J DeCaprio, and U Hansen (1997)
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Nuclear distribution of transcription factors in relation to sites of transcription and RNA polymerase II.
M. Grande, I van der Kraan, L de Jong, and R van Driel (1997)
J. Cell Sci. 110, 1781-1791
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Mitotic regulation of TFIID: inhibition of activator-dependent transcription and changes in subcellular localization..
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Cell Cycle Regulation of a Novel DNA Binding Complex in Saccharomyces cerevisiae with E2F-like Properties.
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Selectivity of Cell Cycle Regulation of Glucocorticoid Receptor Function.
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N Segil, S. Roberts, and N Heintz (1991)
Science 254, 1814-1816
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Science. ISSN 0036-8075 (print), 1095-9203 (online)