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Science 23 August 1991:
Vol. 253. no. 5022, pp. 898 - 900
DOI: 10.1126/science.1876847
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Articles

Science, Vol 253, Issue 5022, 898-900
Copyright © 1991 by American Association for the Advancement of Science

articles

Evidence of lactate dehydrogenase-B allozyme effects in the teleost, Fundulus heteroclitus

L DiMichele, KT Paynter, and DA Powers

Department of Wildlife and Fisheries Sciences, Texas A&M University, College Station 77843.

The evolutionary significance of protein polymorphisms has long been debated. Exponents of the balanced theory advocate that selection operates to maintain polymorphisms, whereas the neoclassical school argues that most genetic variation is neutral. Some studies have suggested that protein polymorphisms are not neutral, but their significance has been questioned because one cannot eliminate the possibility that linked loci were responsible for the observed differences. Evidence is presented that an enzymatic phenotype can affect carbon flow through a metabolic pathway. Glucose flux differences between lactate dehydrogenase-B phenotypes of Fundulus heteroclitus were reversed by substituting the Ldh-B gene product of one homozygous genotype with that of another.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adaptive variation in lactate dehydrogenase-B gene expression: Role of a stress-responsive regulatory element.
P. M. Schulte, H. C. Glemet, A. A. Fiebig, and D. A. Powers (2000)
PNAS 97, 6597-6602
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