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Science 9 August 1991:
Vol. 253. no. 5020, pp. 673 - 675
DOI: 10.1126/science.1871602
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Articles

Science, Vol 253, Issue 5020, 673-675
Copyright © 1991 by American Association for the Advancement of Science

articles

Alteration of the phase and period of a circadian oscillator by a reversible transcription inhibitor

U Raju, C Koumenis, M Nunez-Regueiro, and A Eskin

Department of Biochemical and Biophysical Sciences, University of Houston, TX 77204-5934.

A function for transcription in the mechanism of a circadian oscillator was investigated with the reversible transcription inhibitor 5,6-dichloro-1-beta-D- ribobenzimidazole (DRB). Two-hour treatments with DRB shifted the phase of the circadian rhythm of the isolated eye of Aplysia, and continuous treatments of DRB lengthened the free running period of this rhythm. Camptothecin, an inhibitor of transcription that is structurally unrelated to DRB, had similar effects on the circadian rhythm. These results suggest that transcription may be part of the circadian oscillating mechanism.


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