Science 26 July 1991: Vol. 253. no. 5018, pp. 448 - 451 DOI: 10.1126/science.1862346

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Articles

Reduced Threshold for Luminal Ca2+ Activation of RyR1 Underlies a Causal Mechanism of Porcine Malignant Hyperthermia.

D. Jiang, W. Chen, J. Xiao, R. Wang, H. Kong, P. P. Jones, L. Zhang, B. Fruen, and S. R. W. Chen (2008)
J. Biol. Chem. 283, 20813-20820
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Frequency of the HAL-1843 mutation of the ryanodine receptor gene in dead and nonambulatory-noninjured pigs on arrival at the packing plant.

M. J. Ritter, M. Ellis, G. R. Hollis, F. K. McKeith, D. G. Orellana, P. Van Genugten, S. E. Curtis, and J. M. Schlipf (2008)
J Anim Sci 86, 511-514
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Quantitative trait loci mapping in an F2 Duroc x Pietrain resource population: I. Growth traits.

D. B. Edwards, C. W. Ernst, R. J. Tempelman, G. J. M. Rosa, N. E. Raney, M. D. Hoge, and R. O. Bates (2008)
J Anim Sci 86, 241-253
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Quantitative trait locus mapping in an F2 Duroc x Pietrain resource population: II. Carcass and meat quality traits.

D. B. Edwards, C. W. Ernst, N. E. Raney, M. E. Doumit, M. D. Hoge, and R. O. Bates (2008)
J Anim Sci 86, 254-266
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Molecular approaches in pig breeding to improve meat quality.

R. Davoli and S. Braglia (2008)
Brief Funct Genomic Proteomic
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Deposition rates and accretion patterns of intramuscular fat, loin muscle area, and backfat of Duroc pigs sired by boars from two time periods.

C. R. Schwab, T. J. Baas, K. J. Stalder, and J. W. Mabry (2007)
J Anim Sci 85, 1540-1546
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The halothane gene, energy metabolism, adenosine monophosphate-activated protein kinase, and glycolysis in postmortem pig longissimus dorsi muscle.

Q. W. Shen, K. R. Underwood, W. J. Means, R. J. McCormick, and M. Du (2007)
J Anim Sci 85, 1054-1061
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Could the pale, soft, and exudative condition be explained by distinctive histological characteristics?.

M. Franck, P. Figwer, C. Godfraind, M. T. Poirel, A. Khazzaha, and M. M. Ruchoux (2007)
J Anim Sci 85, 746-753
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Effects of breed, sex, and halothane genotype on fatty acid composition of pork longissimus muscle.

S. Zhang, T. J. Knight, K. J. Stalder, R. N. Goodwin, S. M. Lonergan, and D. C. Beitz (2007)
J Anim Sci 85, 583-591
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Integrating Molecular Biology into the Veterinary Curriculum.

M. T. Ryan and T. Sweeney (2007)
J Vet Med Educ 34, 658-673
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High Postmortem Temperature in Muscle Has Very Similar Consequences in Two Turkey Genetic Lines.

C. Molette, V. Serieye, M. Rossignol, R. Babile, X. Fernandez, and H. Remignon (2006)
Poult. Sci. 85, 2270-2277
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Azumolene Inhibits a Component of Store-operated Calcium Entry Coupled to the Skeletal Muscle Ryanodine Receptor.

X. Zhao, N. Weisleder, X. Han, Z. Pan, J. Parness, M. Brotto, and J. Ma (2006)
J. Biol. Chem. 281, 33477-33486
 |  Abstract »  |  Full Text »  |  PDF »

Identification of quantitative trait loci affecting corpora lutea and number of teats in a Meishan x Duroc F2 resource population.

S. Sato, K. Atsuji, N. Saito, M. Okitsu, S. Sato, A. Komatsuda, T. Mitsuhashi, K. Nirasawa, T. Hayashi, Y. Sugimoto, et al. (2006)
J Anim Sci 84, 2895-2901
 |  Abstract »  |  Full Text »  |  PDF »

Effect of long-term selection for increased leanness on meat and eating quality traits in Duroc swine.

C. R. Schwab, T. J. Baas, K. J. Stalder, and J. W. Mabry (2006)
J Anim Sci 84, 1577-1583
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Identification of quantitative trait loci for carcass composition and pork quality traits in a commercial finishing cross.

H. J. van Wijk, B. Dibbits, E. E. Baron, A. D. Brings, B. Harlizius, M. A. M. Groenen, E. F. Knol, and H. Bovenhuis (2006)
J Anim Sci 84, 789-799
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Effects of halothane sensitivity on mobility status and blood metabolites of HAL-1843-normal pigs after rigorous handling.

C. P. Allison, A. L. Marr, N. L. Berry, D. B. Anderson, D. J. Ivers, L. F. Richardson, K. Keffaber, R. C. Johnson, and M. E. Doumit (2006)
J Anim Sci 84, 1015-1021
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Evaluation of Duroc- vs. Pietrain-sired pigs for growth and composition.

D. B. Edwards, R. J. Tempelman, and R. O. Bates (2006)
J Anim Sci 84, 266-275
 |  Abstract »  |  Full Text »  |  PDF »

Cumulative and Bolus In Vitro Contracture Testing with 4-Chloro-3-Ethylphenol in Malignant Hyperthermia Positive and Negative Human Skeletal Muscles.

M. U. Gerbershagen, M. Fiege, R. Weisshorn, K. Kolodzie, J. S. a. Esch, and F. Wappler (2005)
Anesth. Analg. 101, 710-714
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The heritability of the expression of two stress-regulated gene fragments in pigs.

C. A. Kerr, K. L. Bunter, R. Seymour, B. Shen, and A. Reverter (2005)
J Anim Sci 83, 1753-1765
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Application of genomics to the pork industry.

H. A. M. van der Steen, G. F. W. Prall, and G. S. Plastow (2005)
J Anim Sci 83, E1-8
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Polymorphism of the pig 2,4-dienoyl CoA reductase 1 gene (DECR1) and its association with carcass and meat quality traits.

M. Amills, O. Vidal, L. Varona, A. Tomas, M. Gil, A. Sanchez, and J. L. Noguera (2005)
J Anim Sci 83, 493-498
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The effects of halothane sensitivity on carcass composition and meat quality in HAL-1843-normal pigs.

C. P. Allison, R. C. Johnson, and M. E. Doumit (2005)
J Anim Sci 83, 671-678
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Enhanced response to caffeine and 4-chloro-m-cresol in malignant hyperthermia-susceptible muscle is related in part to chronically elevated resting [Ca2+]i.

J. R. Lopez, N. Linares, I. N. Pessah, and P. D. Allen (2005)
Am J Physiol Cell Physiol 288, C606-C612
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Identification of carcass and meat quality quantitative trait loci in a Landrace pig population selected for growth and leanness.

O. Vidal, J. L. Noguera, M. Amills, L. Varona, M. Gil, N. Jimenez, G. Davalos, J. M. Folch, and A. Sanchez (2005)
J Anim Sci 83, 293-300
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Breed differences and genetic parameters of myoglobin concentration in porcine longissimus muscle.

D. W. Newcom, K. J. Stalder, T. J. Baas, R. N. Goodwin, F. C. Parrish, and B. R. Wiegand (2004)
J Anim Sci 82, 2264-2268
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Multiminicore Myopathy, Central Core Disease, Malignant Hyperthermia Susceptibility, and RYR1 Mutations: One Disease With Many Faces?.

K. D. Mathews and S. A. Moore (2004)
Arch Neurol 61, 27-29
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Commercial application of marker- and gene-assisted selection in livestock: Strategies and lessons.

J. C. M. Dekkers (2004)
J Anim Sci 82, E313-328
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Full pedigree quantitative trait locus analysis in commercial pigs using variance components.

D. J. de Koning, R. Pong-Wong, L. Varona, G. J. Evans, E. Giuffra, A. Sanchez, G. Plastow, J. L. Noguera, L. Andersson, and C. S. Haley (2003)
J Anim Sci 81, 2155-2163
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The ryanodine contracture test may help diagnose susceptiblity to malignant hyperthermia: [Le test de contracture a la ryanodine peut aider a decouvrir une susceptibilite a l'hyperthermie maligne].

D. A. Reuter, M. Anetseder, R. Muller, N. Roewer, and E. J. Hartung (2003)
Can J Anesth 50, 643-648
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Functional Defects in Six Ryanodine Receptor Isoform-1 (RyR1) Mutations Associated with Malignant Hyperthermia and Their Impact on Skeletal Excitation-Contraction Coupling.

T. Yang, T. A. Ta, I. N. Pessah, and P. D. Allen (2003)
J. Biol. Chem. 278, 25722-25730
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Identification of Quantitative Trait Loci for Production Traits in Commercial Pig Populations.

G. J. Evans, E. Giuffra, A. Sanchez, S. Kerje, G. Davalos, O. Vidal, S. Illan, J. L. Noguera, L. Varona, I. Velander, et al. (2003)
Genetics 164, 621-627
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The effect of feeding ractopamine (Paylean) on muscle quality and sensory characteristics in three diverse genetic lines of swine.

G. M. Stoller, H. N. Zerby, S. J. Moeller, T. J. Baas, C. Johnson, and L. E. Watkins (2003)
J Anim Sci 81, 1508-1516
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Ion channel diseases.

C. A. Hubner and T. J. Jentsch (2002)
Hum. Mol. Genet. 11, 2435-2445
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Phenotyping malignant hyperthermia susceptibility by measuring halothane-induced changes in myoplasmic calcium concentration in cultured human skeletal muscle cells.

T. Girard, S. Treves, K. Censier, C. R. Mueller, F. Zorzato, and A. Urwyler (2002)
Br. J. Anaesth. 89, 571-579
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Genetic linkage mapping of quantitative trait loci for behavioral and neuroendocrine stress response traits in pigs.

C. Desautes, J. P. Bidanel, D. Milan, N. Iannuccelli, Y. Amigues, F. Bourgeois, J. C. Caritez, C. Renard, C. Chevalet, and P. Mormede (2002)
J Anim Sci 80, 2276-2285
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Malignant Hyperthermia and Apparent Heat Stroke.

J. R. Tobin, D. R. Jason, V. R. Challa, T. E. Nelson, and N. Sambuughin (2001)
JAMA 286, 168-169
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Mutations of the Cardiac Ryanodine Receptor (RyR2) Gene in Familial Polymorphic Ventricular Tachycardia.

P. J. Laitinen, K. M. Brown, K. Piippo, H. Swan, J. M. Devaney, B. Brahmbhatt, E. A. Donarum, M. Marino, N. Tiso, M. Viitasalo, et al. (2001)
Circulation 103, 485-490
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Malignant hyperthermia: advances in clinical management and diagnosis.

P. M. Hopkins (2000)
Br. J. Anaesth. 85, 118-128
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Postulated Role of Interdomain Interaction within the Ryanodine Receptor in Ca2+ Channel Regulation.

T. Yamamoto, R. El-Hayek, and N. Ikemoto (2000)
J. Biol. Chem. 275, 11618-11625
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A Postulated Role of the Near Amino-terminal Domain of the Ryanodine Receptor in the Regulation of the Sarcoplasmic Reticulum Ca2+ Channel.

R. El-Hayek, Y. Saiki, T. Yamamoto, and N. Ikemoto (1999)
J. Biol. Chem. 274, 33341-33347
 |  Abstract »  |  Full Text »  |  PDF »

The Promise of Comparative Genomics in Mammals.

S. J. O'Brien, M. Menotti-Raymond, W. J. Murphy, W. G. Nash, J. Wienberg, R. Stanyon, N. G. Copeland, N. A. Jenkins, J. E. Womack, and J. A. Marshall Graves (1999)
Science 286, 458-481
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Voltage-Gated Ion Channels and Hereditary Disease.

F. Lehmann-Horn and K. Jurkat-Rott (1999)
Physiol Rev 79, 1317-1372
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Pregnant rat myometrial cells show heterogeneous ryanodine- and caffeine-sensitive calcium stores.

C. Martin, J.-M. Hyvelin, K. E. Chapman, R. Marthan, R. H. Ashley, and J.-P. Savineau (1999)
Am J Physiol Cell Physiol 277, C243-C252
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Mutation screening of the RYR1 gene and identification of two novel mutations in Italian malignant hyperthermia families.

V. Barone, O. Massa, E. Intravaia, A. Bracco, A. Di Martino, V. Tegazzin, S. Cozzolino, and V. Sorrentino (1999)
J. Med. Genet. 36, 115-118
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Oxidation of the skeletal muscle Ca2+ release channel alters calmodulin binding.

J.-Z. Zhang, Y. Wu, B. Y. Williams, G. Rodney, F. Mandel, G. M. Strasburg, and S. L. Hamilton (1999)
Am J Physiol Cell Physiol 276, C46-C53
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Ion channels and neurological disease: DNA based diagnosis is now possible, and ion channels may be important in common paroxysmal disorders.

M. G HANNA, N. W WOOD, and D. M KULLMANN (1998)
J. Neurol. Neurosurg. Psychiatry 65, 427-431
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Multiple Marker Mapping of Quantitative Trait Loci in a Cross Between Outbred Wild Boar and Large White Pigs.

S. A. Knott, L. Marklund, C. S. Haley, K. Andersson, W. Davies, H. Ellegren, M. Fredholm, I. Hansson, B. Hoyheim, K. Lundstrom, et al. (1998)
Genetics 149, 1069-1080
 |  Abstract »  |  Full Text »  |  PDF »

Dantrolene Inhibition of Sarcoplasmic Reticulum Ca2+ Release by Direct and Specific Action at Skeletal Muscle Ryanodine Receptors.

B. R. Fruen, J. R. Mickelson, and C. F. Louis (1997)
J. Biol. Chem. 272, 26965-26971
 |  Abstract »  |  Full Text »  |  PDF »

Caffeine and Halothane Sensitivity of Intracellular Ca2+ Release Is Altered by 15 Calcium Release Channel (Ryanodine Receptor) Mutations Associated with Malignant Hyperthermia and/or Central Core Disease.

J. Tong, H. Oyamada, N. Demaurex, S. Grinstein, T. V. McCarthy, and D. H. MacLennan (1997)
J. Biol. Chem. 272, 26332-26339
 |  Abstract »  |  Full Text »  |  PDF »

Functional Interactions between Cytoplasmic Domains of the Skeletal Muscle Ca2+ Release Channel.

Y. Wu, B. Aghdasi, S. J. Dou, J. Z. Zhang, S. Q. Liu, and S. L. Hamilton (1997)
J. Biol. Chem. 272, 25051-25061
 |  Abstract »  |  Full Text »  |  PDF »

Changes in Ryanodine-Induced Contractures by Stimulus Frequency in Malignant Hyperthermia Susceptible and Malignant Hyperthermia Nonsusceptible Dog Skeletal Muscle.

R. T. Sudo and T. E. Nelson (1997)
J. Pharmacol. Exp. Ther. 282, 1331-1336
 |  Abstract »  |  Full Text »

The Sarcoplasmic Reticulum Ca2+ Channel/Ryanodine Receptor: Modulation by Endogenous Effectors, Drugs and Disease States.

R. Zucchi and S. Ronca-Testoni (1997)
Pharmacol. Rev. 49, 1-52
 |  Abstract »  |  Full Text »  |  PDF »

Functional Characterization of a Distinct Ryanodine Receptor Mutation in Human Malignant Hyperthermia-susceptible Muscle.

M. Richter, L. Schleithoff, T. Deufel, F. Lehmann-Horn, and A. Herrmann-Frank (1997)
J. Biol. Chem. 272, 5256-5260
 |  Abstract »  |  Full Text »  |  PDF »

Livestock genomics comes of age..

M Georges and L Andersson (1996)
Genome Res. 6, 907-921
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Role of Malignant Hyperthermia Domain in the Regulation of Ca2+ Release Channel (Ryanodine Receptor) of Skeletal Muscle Sarcoplasmic Reticulum.

F. Zorzato, P. Menegazzi, S. Treves, and M. Ronjat (1996)
J. Biol. Chem. 271, 22759-22763
 |  Abstract »  |  Full Text »  |  PDF »

Identity-by-descent mapping of recessive traits in livestock: application to map the bovine syndactyly locus to chromosome 15..

C Charlier, F Farnir, P Berzi, P Vanmanshoven, B Brouwers, H Vromans, and M Georges (1996)
Genome Res. 6, 580-589
 |  Abstract »  |  PDF »

Regulation of Tissue-specific Expression of the Skeletal Muscle Ryanodine Receptor Gene.

S. Schmoelzl, T. Leeb, H. Brinkmeier, G. Brem, and B. Brenig (1996)
J. Biol. Chem. 271, 4763-4769
 |  Abstract »  |  Full Text »  |  PDF »

Postexercise Muscle Cramping Associated with Positive Malignant Hyperthermia Contracture Testing.

J. W. Ogletree, J. F. Antognini, and G. A. Gronert (1996)
Am. J. Sports Med. 24, 49-51
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Effect of Ryanodine on Sarcoplasmic Reticulum Ca2+ Accumulation in Nonfailing and Failing Human Myocardium.

L. R. Nimer, D. H. Needleman, S. L. Hamilton, J. Krall, and M. A. Movsesian (1995)
Circulation 92, 2504-2510
 |  Abstract »  |  Full Text »

Identification of Dantrolene Binding Sites in Porcine Skeletal Muscle Sarcoplasmic Reticulum.

J. Parness and S. S. Palnitkar (1995)
J. Biol. Chem. 270, 18465-18472
 |  Abstract »  |  Full Text »  |  PDF »

Hyperthermia.

D. I. Sessler, J. Parness, C. M. Slovis, and M. R. Salzberg (1994)
N. Engl. J. Med. 330, 218-219
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Malignant hyperthermia.

D. MacLennan and M. Phillips (1992)
Science 256, 789-794
 |  Abstract »  |  PDF »

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